公开(公告)号：US20170073708A1

公开(公告)日：2017-03-16

申请号：US15140384

申请日：2016-04-27

Applicant: Genomatica, Inc.

Inventor： Liang WU ,  Axel Christoph TREFZER ,  Stefaan Marie Andre DE WILDEMAN ,  Marco Alexander VAN DEN BERG

IPC: C12P7/44 ,  C12P7/62 ,  C12N15/70 ,  C12P17/10

CPC classification number: C12P7/44 ,  C12N15/70 ,  C12P7/62 ,  C12P17/10

Abstract: The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.

Abstract translation: 本发明涉及一种制备己二酸酯或硫酯的方法。 本发明还涉及从所述酯或硫酯制备己二酸的方法。 此外，本发明提供了许多用于制备所述酯或硫酯的中间体的方法。 本发明还涉及制备6-氨基己酸（6-ACA）的方法，5-甲酰戊酸（5-FVA）的制备方法和己内酰胺的制备方法。 此外，本发明涉及用于根据本发明的方法的宿主细胞。

公开(公告)号：US20180100172A1

公开(公告)日：2018-04-12

申请号：US15599314

申请日：2017-05-18

Applicant: Genomatica, Inc.

Inventor： Petronella Catharina RAEMAKERS-FRANKEN ,  Martin SCHURMANN ,  Axel Christoph TREFZER ,  Stefaan Marie Andre DE WILDEMAN

IPC: C12P13/00 ,  C12P13/02 ,  C07C227/06 ,  C07D201/08 ,  C07D223/10 ,  C07C229/08

CPC classification number: C12P13/001 ,  C07C227/06 ,  C07D201/08 ,  C07D223/10 ,  C12P13/005 ,  C12P13/02 ,  C07C229/08

Abstract: The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing ϵ-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.