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公开(公告)号：US20200299781A1
公开(公告)日：2020-09-24
申请号：US16807769
申请日：2020-03-03
申请人： Genomic Health, Inc.
发明人： Joffre B. Baker , John L. Bryant , Soonmyung Paik , Steven Shak
IPC分类号： C12Q1/6886
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
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2.发明授权公开(公告)号：US11776664B2
公开(公告)日：2023-10-03
申请号：US16952566
申请日：2020-11-19
申请人： Genomic Health, Inc.
发明人： Wayne Cowens , Steven Shak , Audrey Goddard , Dejan Knezevic , Joffre Baker , Michael C. Kiefer , Tara Maddala , Frederick L. Baehner
IPC分类号： G01N33/574 , G16B99/00 , G16B25/10 , G06N7/01
CPC分类号： G16B99/00 , G01N33/57438 , G06N7/01 , G16B25/10 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
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公开(公告)号：US11220715B2
公开(公告)日：2022-01-11
申请号：US15897617
申请日：2018-02-15
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/6886
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
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4.发明申请Gene Expression Profile Algorithm and Test for Determining Prognosis of Prostate Cancer 审中-公开基因表达谱算法和测定前列腺癌的预后公开(公告)号：US20140303002A1
公开(公告)日：2014-10-09
申请号：US14221556
申请日：2014-03-21
申请人： Genomic Health, Inc.
发明人： Steven Shak , Mark Lee , William F. Novotny , Tara Maddala , Michael R. Crager , Diana Cherbavaz , Robert J. Pelham , Carl L. Millward , Dejan Knezevic
CPC分类号： G16B25/00 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G16H50/30
摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes, or their co-expressed genes, from a biological sample obtained from a prostate cancer patient. The genes may be grouped into functional gene subsets for calculating a quantitative score useful to predict a likelihood of a clinical outcome for a prostate cancer patient.
摘要翻译： 本发明提供基于算法的分子测定法，其涉及从前列腺癌患者获得的生物样品中测量基因或其共表达基因的表达水平。 这些基因可以分组成功能性基因子集，用于计算可用于预测前列腺癌患者的临床结果的可能性的定量评分。
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公开(公告)号：US20140287421A1
公开(公告)日：2014-09-25
申请号：US14257723
申请日：2014-04-21
申请人： Genomic Health, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
摘要翻译： 本发明提供了在乳腺癌的诊断和/或预后中重要的基因组。
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公开(公告)号：US11551782B2
公开(公告)日：2023-01-10
申请号：US17086850
申请日：2020-11-02
申请人： Genomic Health, Inc.
发明人： Steven Shak , George Andrew Watson , Michael R. Crager , Tara Maddala , Margarita Lopatin , Audrey Goddard , Dejan Knezevic , Christer Svedman
摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.
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公开(公告)号：US09944990B2
公开(公告)日：2018-04-17
申请号：US14257723
申请日：2014-04-21
申请人： Genomic Health, Inc.
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
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公开(公告)号：US11011252B1
公开(公告)日：2021-05-18
申请号：US15584963
申请日：2017-05-02
申请人： Genomic Health, Inc.
发明人： Steven Shak , Mark Lee , William F. Novotny , Tara Maddala , Michael R. Crager , Diana Cherbavaz , Robert J. Pelham , Carl L. Millward , Dejan Knezevic
IPC分类号： G16B25/00 , C12Q1/6886 , G16H50/30
摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes, or their co-expressed genes, from a biological sample obtained from a prostate cancer patient. The genes may be grouped into functional gene subsets for calculating a quantitative score useful to predict a likelihood of a clinical outcome for a prostate cancer patient.
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9.发明授权公开(公告)号：US10892038B2
公开(公告)日：2021-01-12
申请号：US15368979
申请日：2016-12-05
申请人： GENOMIC HEALTH, INC.
发明人： Wayne Cowens , Steven Shak , Audrey Goddard , Dejan Knezevic , Joffre Baker , Michael C. Kiefer , Tara Maddala , Frederick L. Baehner
IPC分类号： G01N33/574 , G16B99/00 , G06N7/00
摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
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公开(公告)号：US10260104B2
公开(公告)日：2019-04-16
申请号：US14887605
申请日：2015-10-20
申请人： GENOMIC HEALTH, INC.
发明人： Steven Shak , Frederick L. Baehner , Tara Maddala , Mark Lee , Robert J. Pelham , Wayne Cowens , Diana Cherbavaz , Michael C. Kiefer , Michael Crager , Audrey Goddard , Joffre B. Baker
IPC分类号： G06F19/00 , C12Q1/6886
摘要： The present disclosure includes assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for the patient, and likelihood that the patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status.
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