公开(公告)号：US20240096451A1

公开(公告)日：2024-03-21

申请号：US18454312

申请日：2023-08-23

申请人： Genomic Health, Inc.

发明人： Wayne Cowens ,  Steven SHAK ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Joffre Baker ,  Michael C. Kiefer ,  Tara MADDALA ,  Frederick L. Baehner

IPC分类号： G16B99/00 ,  G01N33/574 ,  G06N7/01 ,  G16B25/10

CPC分类号： G16B99/00 ,  G01N33/57438 ,  G06N7/01 ,  G16B25/10 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.

公开(公告)号：US20210151122A1

公开(公告)日：2021-05-20

申请号：US17086850

申请日：2020-11-02

申请人： Genomic Health, Inc.

发明人： Steven SHAK ,  George Andrew WATSON ,  Michael R. CRAGER ,  Tara MADDALA ,  Margarita LOPATIN ,  Audrey GODDARD ,  Dejan KNEZEVIC ,  Christer SVEDMAN

IPC分类号： G16B20/00 ,  G16C99/00 ,  C12Q1/6886 ,  G16H50/30

摘要： The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the quantitative score and the gene subsets may be weighted according to their contribution to cancer recurrence.

公开(公告)号：US20210062275A1

公开(公告)日：2021-03-04

申请号：US17018143

申请日：2020-09-11

申请人： GENOMIC HEALTH, INC.

发明人： Joffre B. BAKER ,  Maureen T. CRONIN ,  Francois COLLIN ,  Mei-Lan LIU

IPC分类号： C12Q1/6886 ,  G16B25/00

摘要： The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.

公开(公告)号：US20200299781A1

公开(公告)日：2020-09-24

申请号：US16807769

申请日：2020-03-03

申请人： Genomic Health, Inc.

发明人： Joffre B. Baker ,  John L. Bryant ,  Soonmyung Paik ,  Steven Shak

IPC分类号： C12Q1/6886

摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.

公开(公告)号：US20200255911A1

公开(公告)日：2020-08-13

申请号：US16800292

申请日：2020-02-25

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  Frederick L. BAEHNER ,  Tara MADDALA ,  Mark LEE ,  Robert J. PELHAM ,  Wayne COWENS ,  Diana CHERBAVAZ ,  Michael C. KIEFER ,  Michael CRAGER ,  Audrey GODDARD ,  Joffre B. BAKER

IPC分类号： C12Q1/6886

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：US20200040400A1

公开(公告)日：2020-02-06

申请号：US16485203

申请日：2018-02-12

申请人： Genomic Health, Inc.

发明人： Ruixiao LU ,  Michael CRAGER ,  Nan ZHANG ,  Tara MADDALA ,  Phillip FEBBO ,  Hugh Jeffrey LAWRENCE

IPC分类号： C12Q1/6886 ,  C12Q1/6809

摘要： The present disclosure relates to uses of a multiple gene-expression based Genomic Prostate Score™ (GPS™) algorithm for assessment of various clinical endpoints in prostate cancer patients, such as risks of clinical recurrence (CR), biochemical recurrence (BCR), distant metastasis (Mets), and prostate cancer death (PCD). In some embodiments, GPS result is determined for low and intermediate risk prostate cancer patients in order to assist in determining treatment strategies for those patients.

公开(公告)号：US20190249260A1

公开(公告)日：2019-08-15

申请号：US16282540

申请日：2019-02-22

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  Frederick L. BAEHNER ,  Tara MADDALA ,  Mark LEE ,  Robert J. PELHAM ,  Wayne COWENS ,  Diana CHERBAVAZ ,  Michael C. KIEFER ,  Michael CRAGER ,  Audrey GODDARD ,  Joffre B. BAKER

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：US20160097105A1

公开(公告)日：2016-04-07

申请号：US14887605

申请日：2015-10-20

申请人： GENOMIC HEALTH, INC.

发明人： Steven SHAK ,  Frederick L. BAEHNER ,  Tara MADDALA ,  Mark LEE ,  Robert J. PELHAM ,  Wayne COWENS ,  Diana CHERBAVAZ ,  Michael C. KIEFER ,  Michael CRAGER ,  Audrey GODDARD ,  Joffre B. BAKER

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

摘要翻译： 涉及从前列腺癌患者获得的生物样品中测量预后生物标志物或共表达生物标志物的表达水平的分子测定，以及测量的表达水平的分析以提供关于所述患者的可能预后的信息，以及可能性 所述患者将具有前列腺癌的复发，或通过临床结果或TMPRSS2融合状态的可能性来分类肿瘤。

公开(公告)号：US20230374604A1

公开(公告)日：2023-11-23

申请号：US18130547

申请日：2023-04-04

申请人： Genomic Health, Inc.

发明人： Margarita LOPATIN ,  Athanasios TSIATIS ,  Christopher N. SILK ,  David P. MILLER ,  Michael R. CRAGER ,  Phillip FEBBO ,  Dejan KNEZEVIC

IPC分类号： C12Q1/6886 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/154 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7028

摘要： The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.

公开(公告)号：US11807900B2

公开(公告)日：2023-11-07

申请号：US16449075

申请日：2019-06-21

申请人： GENOMIC HEALTH, INC.

发明人： Hubert Yeung ,  Amy Lee Hsieh Yuan ,  Chun Wai Lee ,  Gabriel Jesus Samuel Perlas Moraleda ,  Jonathan M. Cassel

IPC分类号： C12Q1/68 ,  C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6865 ,  C12Q1/6813

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6813 ,  C12Q1/6865 ,  C12Q2523/115 ,  C12Q2523/301 ,  C12Q2523/305 ,  C12Q2523/31

摘要： Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.