公开(公告)号：US20230272397A1

公开(公告)日：2023-08-31

申请号：US18192492

申请日：2023-03-29

申请人： Genus PLC

发明人： Andrew Mark Cigan ,  Jonathan Edward Lightner ,  Matthew Scott Culbertson ,  William Thomas Christianson ,  Benjamin Beaton ,  Brian Burger ,  Dylan Barnes ,  Matthew Campbell

IPC分类号： C12N15/113 ,  A01K67/027 ,  C12N9/22 ,  C12N15/877

CPC分类号： C12N15/113 ,  A01K67/0275 ,  C12N9/22 ,  C12N15/8778 ,  C12N2310/20 ,  A01K2217/052 ,  A01K2227/108 ,  C12N2320/34

摘要： The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties

公开(公告)号：US20220135976A1

公开(公告)日：2022-05-05

申请号：US17581239

申请日：2022-01-21

申请人： Genus PLC

发明人： Andrew Mark Cigan ,  Jonathan Edward Lightner ,  Matthew Scott Culbertson ,  William Thomas Christianson ,  Benjamin Beaton ,  Brian Burger ,  Dylan Barnes ,  Matthew Campbell

IPC分类号： C12N15/113 ,  A01K67/027 ,  C12N9/22 ,  C12N15/877

摘要： The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties

公开(公告)号：US11208659B2

公开(公告)日：2021-12-28

申请号：US17307369

申请日：2021-05-04

申请人： Genus PLC

发明人： Andrew Mark Cigan ,  Jonathan Edward Lightner ,  Matthew Scott Culbertson ,  William Thomas Christianson ,  Benjamin Beaton ,  Brian Burger ,  Dylan Barnes ,  Matthew Campbell

IPC分类号： A01K67/027 ,  C12N15/00 ,  C12N15/113 ,  C12N9/22 ,  C12N15/877

摘要： The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties.

公开(公告)号：US11535850B2

公开(公告)日：2022-12-27

申请号：US17581239

申请日：2022-01-21

申请人： Genus PLC

发明人： Andrew Mark Cigan ,  Jonathan Edward Lightner ,  Matthew Scott Culbertson ,  William Thomas Christianson ,  Benjamin Beaton ,  Brian Burger ,  Dylan Barnes ,  Matthew Campbell

IPC分类号： A01K67/027 ,  C12N15/113 ,  C12N9/22 ,  C12N15/877

摘要： The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties.

公开(公告)号：US20210348165A1

公开(公告)日：2021-11-11

申请号：US17307369

申请日：2021-05-04

申请人： Genus PLC

发明人： Andrew Mark Cigan ,  Jonathan Edward Lightner ,  Matthew Scott Culbertson ,  William Thomas Christianson ,  Benjamin Beaton ,  Brian Burger ,  Dylan Barnes ,  Matthew Campbell

IPC分类号： C12N15/113 ,  C12N9/22 ,  C12N15/877 ,  A01K67/027

摘要： The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties