公开(公告)号：US20180117211A1

公开(公告)日：2018-05-03

申请号：US15621704

申请日：2017-06-13

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  James A. Wilkie ,  Peter N. Madras

IPC分类号： A61L24/04 ,  A61B17/00

CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12004 ,  A61K31/722 ,  A61K31/728 ,  A61K31/765 ,  A61K45/06 ,  A61K51/06 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/406 ,  A61L2400/04 ,  C08L71/02

摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

公开(公告)号：US20150018872A1

公开(公告)日：2015-01-15

申请号：US14505076

申请日：2014-10-02

申请人： Genzyme Corporation

发明人： James A. Wilkie

IPC分类号： A61L31/04 ,  A61L31/06 ,  A61B17/00

CPC分类号： A61L31/042 ,  A61B17/0057 ,  A61B2017/00641 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/18 ,  A61L2400/04

摘要： One aspect of the present invention relates to a method to control biological fluid flow at a site in a mammal by use of an in situ formed polymer plug. In certain embodiments, the present invention relates to a method to control bleeding following a catheterization procedure, a method to control leakage of cerebral spinal fluid following a lumbar puncture, a method to seal a fistula, or a method to control the flow of serous fluid after a lymphadenectomy. In certain embodiments, the polymer plug is generated in situ by temperature changes, pH changes or ionic interactions. In certain embodiments, the polymer plug comprises at least one optionally purified reverse thermosensitive polymer.

摘要翻译： 本发明的一个方面涉及通过使用原位形成的聚合物塞来控制哺乳动物部位的生物流体流动的方法。 在某些实施方案中，本发明涉及在导管插入术后控制出血的方法，在腰椎穿刺后控制脑脊液的渗漏的方法，密封瘘的方法或控制浆液的流动的方法 淋巴结清扫术后。 在某些实施方案中，通过温度变化，pH变化或离子相互作用原位产生聚合物塞。 在某些实施方案中，聚合物塞包含至少一种任选纯化的反向热敏聚合物。

公开(公告)号：US20170238938A1

公开(公告)日：2017-08-24

申请号：US15282186

申请日：2016-09-30

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  James A. Wilkie

IPC分类号： A61B17/12 ,  A61B18/26 ,  A61M5/00 ,  A61B17/22

CPC分类号： A61B17/12186 ,  A61B17/12022 ,  A61B17/12099 ,  A61B17/12109 ,  A61B17/12195 ,  A61B17/22012 ,  A61B18/26 ,  A61B2017/22067 ,  A61M5/007

摘要： One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen. In one embodiment, the instant invention provides a method of using a polymer plug to occlude a lumen distal to a calculi, whereby calculi fragments resulting from lithotripsy are prevented from traveling up the lumen. In certain embodiments, a dual lumen catheter is utilized to inject two solutions proximal to the calculi, the mixing of said solutions causing a polymer plug to form.

公开(公告)号：US20210353301A1

公开(公告)日：2021-11-18

申请号：US17187409

申请日：2021-02-26

申请人： Genzyme Corporation

发明人： Jean-Marie Vogel ,  James A. Wilkie

IPC分类号： A61B17/12 ,  A61B17/22 ,  A61B18/26 ,  A61M5/00

摘要： One aspect of the present invention provides a method for the treatment of lithiasis, which mitigates the risk of damage to surrounding body tissue when removing a calculi (e.g., biological concretions, such as urinary, biliary, and pancreatic stones) that obstructs or may otherwise be present within a body's anatomical lumen. In one embodiment, the instant invention provides a method of using a polymer plug to occlude a lumen distal to a calculi, whereby calculi fragments resulting from lithotripsy are prevented from traveling up the lumen. In certain embodiments, a dual lumen catheter is utilized to inject two solutions proximal to the calculi, the mixing of said solutions causing a polymer plug to form.

公开(公告)号：US20170043050A1

公开(公告)日：2017-02-16

申请号：US15074432

申请日：2016-03-18

申请人： Genzyme Corporation ,  Lahey Clinic, Inc.

发明人： Jean-Marie Vogel ,  James A. Wilkie ,  Peter N. Madras

IPC分类号： A61L24/04 ,  A61K31/765 ,  A61K45/06 ,  A61L24/00

CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12004 ,  A61K31/722 ,  A61K31/728 ,  A61K31/765 ,  A61K45/06 ,  A61K51/06 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/406 ,  A61L2400/04 ,  C08L71/02

摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

摘要翻译： 公开了通过使用基于聚合物溶液的内部封堵器来控制出血的组合物，方法和试剂盒，包括在肾单位保护手术中使用反向热敏聚合物，其产生完全无血的手术领域，允许快速切除。 在某些实施方案中，在一定量的时间之后，流程逐渐恢复，对肾没有明显的不利后果。 在某些实施方案中，可以通过冷却肾来加速血流量的返回。 用于灌注器官止血的组合物，方法和试剂盒也可用于简化或实现其他器官手术或介入手术，包括肝手术，前列腺手术，脑外科手术，子宫手术，脾脏手术和任何高度血管化的手术 器官。

公开(公告)号：US20140205542A1

公开(公告)日：2014-07-24

申请号：US14225299

申请日：2014-03-25

申请人： Lahey Clinic, Inc. ,  Genzyme Corporation

发明人： Jean-Marie Vogel ,  James A. Wilkie ,  Peter N. Madras

IPC分类号： A61K31/765 ,  A61K31/722 ,  A61K31/728 ,  A61K45/06 ,  A61K51/06

CPC分类号： A61L24/046 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12186 ,  A61B17/12195 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61B2017/12004 ,  A61K31/722 ,  A61K31/728 ,  A61K31/765 ,  A61K45/06 ,  A61K51/06 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/406 ,  A61L2400/04 ,  C08L71/02

摘要： Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in nephron-sparing surgeries, which produces a completely bloodless surgical field, allowing speedy resection. In certain embodiments, after a certain amount of time, the flow gradually resumes, with no apparent adverse consequences to the kidney. In certain embodiments, return of blood flow may be accelerated by cooling the kidney. The compositions, methods and kits for perfusive organ hemostasis can also be used to simplify or to enable other organ surgeries or interventional procedures, including liver surgery, prostate surgery, brain surgery, surgery of the uterus, spleen surgery and any surgery on any highly vascularized organs.

摘要翻译： 公开了通过使用基于聚合物溶液的内部封堵器来控制出血的组合物，方法和试剂盒，包括在肾单位保护手术中使用反向热敏聚合物，其产生完全无血的手术领域，允许快速切除。 在某些实施方案中，在一定量的时间之后，流程逐渐恢复，对肾没有明显的不利后果。 在某些实施方案中，可以通过冷却肾来加速血流量的返回。 用于灌注器官止血的组合物，方法和试剂盒也可用于简化或实现其他器官手术或介入手术，包括肝手术，前列腺手术，脑外科手术，子宫手术，脾脏手术和任何高度血管化的手术 器官。