公开(公告)号：US11911440B2

公开(公告)日：2024-02-27

申请号：US18054500

申请日：2022-11-10

Applicant: Genzyme Corporation

Inventor： Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K48/00 ,  C12N15/86 ,  A61K38/17 ,  A61K31/7088 ,  C12N7/00 ,  C07K14/47

CPC classification number: A61K38/1709 ,  A61K31/7088 ,  A61K48/00 ,  A61K48/005 ,  A61K48/0008 ,  A61K48/0075 ,  C07K14/4702 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14133 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

公开(公告)号：US20230364200A1

公开(公告)日：2023-11-16

申请号：US18066149

申请日：2022-12-14

Applicant: Genzyme Corporation

Inventor： James Dodge ,  Lamya Shihabuddin ,  Catherine O’Riordan

IPC: A61K38/30 ,  A61K48/00

CPC classification number: A61K38/30 ,  A61K48/005 ,  A61K48/0075 ,  C12N15/8645 ,  C12N2799/025

Abstract: This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject’s spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject’s spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject’s brain.

公开(公告)号：US10080783B2

公开(公告)日：2018-09-25

申请号：US14559851

申请日：2014-12-03

Applicant: Genzyme Corporation

Inventor： James Dodge ,  Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K38/46 ,  A61K9/00 ,  A61K38/47

CPC classification number: A61K38/465 ,  A61K9/0019 ,  A61K38/47 ,  C12Y301/04012 ,  C12Y301/06013 ,  C12Y302/0102 ,  C12Y302/01045 ,  C12Y302/01076 ,  C12Y304/14

Abstract: Lysosomal storage diseases can be successfully treated using intraventricular delivery of the enzyme which is etiologically deficient in the disease. The administration can be performed slowly to achieve maximum effect. Surprisingly, effects are seen on both sides of the blood-brain barrier, making this an ideal delivery means for lysosomal storage diseases which affect both brain and visceral organs.

公开(公告)号：US10369193B2

公开(公告)日：2019-08-06

申请号：US15160949

申请日：2016-05-20

Applicant: Genzyme Corporation

Inventor： Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K38/17 ,  C12N7/00 ,  A61K48/00 ,  C07K14/47 ,  A61K31/7088 ,  C12N15/86

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

公开(公告)号：US11554161B2

公开(公告)日：2023-01-17

申请号：US16546070

申请日：2019-08-20

Applicant: Genzyme Corporation

Inventor： James Dodge ,  Lamya Shihabuddin ,  Catherine O'Riordan

IPC: A61K48/00 ,  C12N15/79 ,  C07H21/04 ,  A61K38/30 ,  C12N15/864

Abstract: This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.

公开(公告)号：US20230135379A1

公开(公告)日：2023-05-04

申请号：US18054500

申请日：2022-11-10

Applicant: Genzyme Corporation

Inventor： Marco A. PASSINI ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K38/17 ,  A61K31/7088 ,  A61K48/00 ,  C12N15/86 ,  C12N7/00 ,  C07K14/47

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

公开(公告)号：US09415119B2

公开(公告)日：2016-08-16

申请号：US14876683

申请日：2015-10-06

Applicant: Genzyme Corporation

Inventor： Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K48/00 ,  C12N7/00 ,  A61K31/7088 ,  C12N15/86 ,  A61K38/17

CPC classification number: A61K38/1709 ,  A61K31/7088 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4702 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14133 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

Abstract translation: 公开了用于治疗影响运动功能的疾病的组合物和方法，例如受到疾病或脑和/或脊髓损伤的运动功能。

公开(公告)号：US20240350584A1

公开(公告)日：2024-10-24

申请号：US18616511

申请日：2024-03-26

Applicant: Genzyme Corporation

Inventor： Marco A. PASSINI ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K38/17 ,  A61K31/7088 ,  A61K48/00 ,  C07K14/47 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K38/1709 ,  A61K31/7088 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4702 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14133 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

公开(公告)号：US11975043B2

公开(公告)日：2024-05-07

申请号：US18046363

申请日：2022-10-13

Applicant: Genzyme Corporation

Inventor： Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K48/00 ,  A61K31/7088 ,  A61K38/17 ,  C07K14/47 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K38/1709 ,  A61K31/7088 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4702 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14133 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.

公开(公告)号：US20240033323A1

公开(公告)日：2024-02-01

申请号：US18488346

申请日：2023-10-17

Applicant: Genzyme Corporation

Inventor： Marco A. PASSINI ,  Lamya Shihabuddin ,  Seng H. Cheng

IPC: A61K38/17 ,  A61K31/7088 ,  A61K48/00 ,  C12N15/86 ,  C12N7/00 ,  C07K14/47

CPC classification number: A61K38/1709 ,  A61K31/7088 ,  A61K48/005 ,  C12N15/86 ,  A61K48/00 ,  A61K48/0075 ,  C12N7/00 ,  A61K48/0008 ,  C07K14/4702 ,  C12N2750/14171 ,  C12N2750/14143 ,  C12N2750/14133 ,  C12N2750/14121

Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.