公开(公告)号：US20190272894A1

公开(公告)日：2019-09-05

申请号：US16290713

申请日：2019-03-01

Applicant: Genzyme Corporation

Inventor： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock ,  Lin Huang

IPC: G16C20/10 ,  C12M1/00 ,  C12M1/36 ,  C12M1/12 ,  C07K1/16

Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.