公开(公告)号：US20220101953A1

公开(公告)日：2022-03-31

申请号：US17643128

申请日：2021-12-07

申请人： Genzyme Corporation

发明人： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC分类号： G16C20/10 ,  C12M1/00 ,  C07K1/16 ,  C12M1/12 ,  C12M1/36 ,  G01N30/86 ,  G01N30/46 ,  G01N30/78 ,  G01N21/552 ,  G01N21/3577

摘要： The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US12073924B2

公开(公告)日：2024-08-27

申请号：US17643128

申请日：2021-12-07

申请人： Genzyme Corporation

发明人： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC分类号： C12M3/00 ,  B01L3/00 ,  C07K1/16 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  G16C20/10 ,  B01D15/18 ,  G01N21/35 ,  G01N21/84 ,  G01N30/88

CPC分类号： G16C20/10 ,  C07K1/16 ,  C12M21/14 ,  C12M37/00 ,  C12M41/48 ,  C12M47/12 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  B01D15/1814 ,  B01D15/1871 ,  G01N2021/3595 ,  G01N2021/8416 ,  G01N2030/8813 ,  G01N2030/8886 ,  G01N2201/129

摘要： The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US20190272894A1

公开(公告)日：2019-09-05

申请号：US16290713

申请日：2019-03-01

申请人： Genzyme Corporation

发明人： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock ,  Lin Huang

IPC分类号： G16C20/10 ,  C12M1/00 ,  C12M1/36 ,  C12M1/12 ,  C07K1/16

摘要： The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.