公开(公告)号：US20240262923A1

公开(公告)日：2024-08-08

申请号：US18389951

申请日：2023-12-20

申请人： Genzyme Corporation

发明人： Marta AMARAL ,  Christian BEIL ,  Laurence BERTHOU-SOULIÉ ,  Joerg BIRKENFELD ,  Béatrice CAMERON ,  Margot CUCCHETTI ,  Tarik DABDOUBI ,  Klervi DESRUMEAUX ,  Fangyong DU ,  Norbert FURTMANN ,  Soraya HOELPER ,  Yan LI ,  Guizhong LIU ,  Peter Peizhi LUO ,  Ercole RAO ,  Ingrid SASSOON ,  Marion SCHNEIDER ,  Fabienne SOUBRIER ,  Emmanuelle VIGNE

IPC分类号： C07K16/28 ,  C07K14/47

CPC分类号： C07K16/2878 ,  C07K14/47 ,  C07K16/2818 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/50

摘要： Anti-4-1BB and anti-PD-1 binding proteins, as well as bispecific anti-4-1BB/anti-PD-1 binding proteins, including conditionally-active derivatives thereof, are provided. Therapeutic and diagnostic methods of using binding proteins are provided.