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公开(公告)号：US20080038230A1
公开(公告)日：2008-02-14
申请号：US11596397
申请日：2005-05-12
CPC分类号： G01N33/5073 , C12N5/0631 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39
摘要： The present invention relates generally to a method for the generation of a substantially homogenous population of undifferentiated cells. More particularly, the present invention relates to a method for isolating a substantially homogenous population of stem cells, and in particular, mammary stem cells (MaSCs). The MaSCs of the present invention are isolated on the basis of differential levels of proteins present on their cell surface. The MaSCs of the present invention are particularly useful as targets for identifying agents which modulate MaSC survival, self-renewal, proliferation and/or differentiation in both normal and diseased tissue such as, but not limited to, tumor tissue, and, also as source of tissue for the regeneration, replacement and/or augmentation of tissue damaged and/or lost after disease or injury.
摘要翻译： 本发明一般涉及产生基本均匀的未分化细胞群的方法。 更具体地说，本发明涉及用于分离基本均匀的干细胞群，特别是乳腺干细胞（MaSCs）的方法。 基于存在于其细胞表面上的蛋白质的差异水平分离本发明的MaSC。 本发明的MaSCs特别可用作鉴定调节正常组织和患病组织中MaSC存活，自我更新，增殖和/或分化的药剂的靶标，所述组织例如但不限于肿瘤组织，以及作为来源 的组织用于在疾病或损伤后损伤和/或丢失的组织的再生，置换和/或增加。
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公开(公告)号：US08741635B2
公开(公告)日：2014-06-03
申请号：US11596397
申请日：2005-05-12
IPC分类号： C12N5/00
CPC分类号： G01N33/5073 , C12N5/0631 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39
摘要： The present invention relates generally to a method for the generation of a substantially homogenous population of undifferentiated cells. More particularly, the present invention relates to a method for isolating a substantially homogenous population of stem cells, and in particular, mammary stem cells (MaSCs). The MaSCs of the present invention are isolated on the basis of differential levels of proteins present on their cell surface. The MaSCs of the present invention are particularly useful as targets for identifying agents which modulate MaSC survival, self-renewal, proliferation and/or differentiation in both normal and diseased tissue such as, but not limited to, tumor tissue, and, also as source of tissue for the regeneration, replacement and/or augmentation of tissue damaged and/or lost after disease or injury.
摘要翻译： 本发明一般涉及产生基本均匀的未分化细胞群的方法。 更具体地说，本发明涉及用于分离基本均匀的干细胞群，特别是乳腺干细胞（MaSCs）的方法。 基于存在于其细胞表面上的蛋白质的差异水平分离本发明的MaSC。 本发明的MaSCs特别可用作鉴定调节正常组织和患病组织中MaSC存活，自我更新，增殖和/或分化的药剂的靶标，所述组织例如但不限于肿瘤组织，以及作为来源 的组织用于在疾病或损伤后损伤和/或丢失的组织的再生，置换和/或增加。
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公开(公告)号：US20060265745A1
公开(公告)日：2006-11-23
申请号：US10483068
申请日：2002-07-17
申请人： Mark Shackleton , Paul Hodgson
发明人： Mark Shackleton , Paul Hodgson
IPC分类号： G06F12/14
CPC分类号： H04L63/1408 , G06F21/552 , G06F21/566 , H04L43/045 , H04L43/062 , H04L63/145
摘要： Embodiments of the invention are concerned with a method of, and apparatus for, identifying types of network behaviour for use in identifying aberrant network behaviour. In particular, embodiments are concerned with identifying email viruses. The method comprises the steps of: collecting data representative of network traffic that has travelled over a network; training a classification means to recognise a plurality of network behaviour types from the collected data; and for unseen data travelling over the network, classifying the unseen data into one of the defined network behaviour types.
摘要翻译： 本发明的实施例涉及用于识别用于识别异常网络行为的网络行为类型的方法和装置。 具体地，实施例涉及识别电子邮件病毒。 该方法包括以下步骤：收集表示通过网络行进的网络流量的数据; 训练分类装置，用于从所收集的数据识别多个网络行为类型; 并且对于在网络上行进的未知数据，将未知数据分类为所定义的网络行为类型之一。
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公开(公告)号：US20060195325A1
公开(公告)日：2006-08-31
申请号：US10550203
申请日：2003-12-02
申请人： Richard Tateson , Erwin Bonsma , Cefn Hoile , Mark Shackleton
发明人： Richard Tateson , Erwin Bonsma , Cefn Hoile , Mark Shackleton
IPC分类号： G06Q99/00
CPC分类号： G06F16/3326 , G06F16/9032
摘要： A browsing process is driven by user interaction. The user is presented with a selection of items 511, 512, . . . etc from a range. The user can give inputs representing interest in one or other of the items displayed. The inputs represent rewards, which are distributed to attribute data items or “keywords” associated with the display items. These keywords are transparent to the user, but represent characteristics of the display items with which they are associated. The browsing system selects items for display according to a probabilistic function weighted to favour those having the keywords which have accrued the highest number of rewards, these being the display items having the most keywords in common with display items previously rewarded by the user during the browsing session. Partial or negative weightings may also be applied to the keyword associations, which are also taken into account in the selection process.
摘要翻译： 浏览过程由用户交互驱动。 向用户呈现项目511,512的选择。 。 。 等等。 用户可以给出表示在所显示的一个或另一个项目中的兴趣的输入。 输入表示奖励，其被分配给与显示项目相关联的属性数据项或“关键字”。 这些关键字对于用户是透明的，而是表示与它们相关联的显示项目的特征。 浏览系统根据加权的概率函数来选择要显示的项目，以便有利于具有最高奖励数量的关键字的那些，这些是与浏览期间由用户预先奖励的显示项目有最多关键字的显示项目 会话 关键字关联也可以应用部分或负重权重，这也在选择过程中也被考虑在内。
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公开(公告)号：US20070264012A1
公开(公告)日：2007-11-15
申请号：US11663957
申请日：2005-09-20
申请人： Peter Healey , Edmund Sikora , David Heatley , Mark Shackleton
发明人： Peter Healey , Edmund Sikora , David Heatley , Mark Shackleton
IPC分类号： H04B10/08
CPC分类号： H04B10/079 , H04B10/071 , H04B10/85
摘要： The present invention relates to the location or identification of a waveguide, in particular where a disturbance is applied to the optical waveguide. This is achieved by: (a) monitoring the waveguide at a first location to sense a disturbance along the waveguide; (b) causing a disturbance to the waveguide at a second location; (c) transmitting a sensor signal to the second location; and, (d) inferring, from the sensor signal, the presence or identity of the waveguide at the second location.
摘要翻译： 本发明涉及波导的位置或识别，特别是当对光波导施加干扰时。 这通过以下方式实现：（a）在第一位置处监测波导以感测沿波导的扰动; （b）在第二位置引起对波导的干扰; （c）将传感器信号传送到第二位置; 并且（d）从传感器信号推断在第二位置处的波导的存在或身份。
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