-
公开(公告)号:US08785153B2
公开(公告)日:2014-07-22
申请号:US13402399
申请日:2012-02-22
申请人: Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
发明人: Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
IPC分类号: C12P21/08
CPC分类号: C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
摘要: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
摘要翻译: 结合IL33R的抗体,其特征在于重链可变结构域包含SEQ ID NO:1的CDR3区,SEQ ID NO:2的CDR2区和SEQ ID NO:3的CDR1区,并且其中轻链可变区 结构域包含SEQ ID NO:4的CDR3区,SEQ ID NO:5的CDR2区和SEQ ID NO:6的CDR1区或嵌合,人源化或T细胞表位缺失的抗体变体具有治疗的有利性质 的炎性疾病。
-
公开(公告)号:US20120213774A1
公开(公告)日:2012-08-23
申请号:US13402399
申请日:2012-02-22
申请人: Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
发明人: Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
IPC分类号: A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , A61P11/06 , C12N1/21 , C12P21/00 , A61P19/02 , A61P1/04 , C07K16/24 , C12N1/19
CPC分类号: C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
摘要: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
摘要翻译: 结合IL33R的抗体,其特征在于重链可变结构域包含SEQ ID NO:1的CDR3区,SEQ ID NO:2的CDR2区和SEQ ID NO:3的CDR1区,并且其中轻链可变区 结构域包含SEQ ID NO:4的CDR3区,SEQ ID NO:5的CDR2区和SEQ ID NO:6的CDR1区或嵌合,人源化或T细胞表位缺失的抗体变体具有治疗的有利性质 的炎性疾病。
-
公开(公告)号:US09169323B2
公开(公告)日:2015-10-27
申请号:US13582964
申请日:2011-03-03
申请人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
IPC分类号: A61K39/395 , A61K51/10 , A61K39/00 , C07K16/00 , C12P21/08 , A61P35/00 , A61P35/04 , C07K16/28
CPC分类号: C07K16/2866 , A61K47/6849 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
-
公开(公告)号:US08999327B2
公开(公告)日:2015-04-07
申请号:US12962445
申请日:2010-12-07
申请人: Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Kerstin Krueger
发明人: Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Martin Lanzendoerfer
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译: 本发明涉及针对人CSF-1R(抗CSF-1R抗体)的抗体,其制备方法,含有所述抗体的药物组合物及其用途。
-
公开(公告)号:US08900581B2
公开(公告)日:2014-12-02
申请号:US12962445
申请日:2010-12-07
申请人: Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Kerstin Krueger
发明人: Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Martin Lanzendoerfer
IPC分类号: A61K39/395
摘要: The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
-
公开(公告)号:US09221910B2
公开(公告)日:2015-12-29
申请号:US13582989
申请日:2011-03-03
申请人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
IPC分类号: A61K39/395 , C07K16/28 , C12N5/12
CPC分类号: C07K16/2866 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译: 本发明涉及针对人CSF-1R(CSF-1R抗体)的抗体,其制备方法,含有所述抗体的药物组合物及其用途。
-
公开(公告)号:US20130005949A1
公开(公告)日:2013-01-03
申请号:US13582989
申请日:2011-03-03
申请人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
IPC分类号: C07K16/28 , C12N15/13 , C12N15/63 , C12N1/21 , C07K16/30 , C12N5/10 , C12N1/19 , C07K16/46 , C12P21/02
CPC分类号: C07K16/2866 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
-
公开(公告)号:US20120329997A1
公开(公告)日:2012-12-27
申请号:US13582964
申请日:2011-03-03
申请人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人: Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
CPC分类号: C07K16/2866 , A61K47/6849 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译: 本发明涉及针对人CSF-1R(CSF-1R抗体)的抗体,其制备方法,含有所述抗体的药物组合物及其用途。
-
公开(公告)号:US08883975B2
公开(公告)日:2014-11-11
申请号:US13218293
申请日:2011-08-25
申请人: Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
发明人: Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
IPC分类号: C07K16/00
CPC分类号: C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要: The invention provides anti-IL-18R1 antibodies and methods of using the same.
摘要翻译: 本发明提供抗IL-18R1抗体及其使用方法。
-
公开(公告)号:US20120156198A1
公开(公告)日:2012-06-21
申请号:US13218293
申请日:2011-08-25
申请人: Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
发明人: Michael Brandt , Jens Fischer , Stefan Jenewein , Klaus Kaluza , Eileen Samy , Stefan Seeber
IPC分类号: A61K39/395 , C12N15/13 , A61P11/00 , A61P29/00 , A61P37/00 , A61P19/04 , A61P17/06 , A61P19/08 , A61P35/00 , C12P21/02 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K16/28
CPC分类号: C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
摘要: The invention provides anti-IL-18R1 antibodies and methods of using the same.
摘要翻译: 本发明提供抗IL-18R1抗体及其使用方法。
-
-
-
-
-
-
-
-
-