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公开(公告)号：US08785153B2
公开(公告)日：2014-07-22
申请号：US13402399
申请日：2012-02-22
申请人： Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
发明人： Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
IPC分类号： C12P21/08
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
摘要： An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
摘要翻译： 结合IL33R的抗体，其特征在于重链可变结构域包含SEQ ID NO：1的CDR3区，SEQ ID NO：2的CDR2区和SEQ ID NO：3的CDR1区，并且其中轻链可变区 结构域包含SEQ ID NO：4的CDR3区，SEQ ID NO：5的CDR2区和SEQ ID NO：6的CDR1区或嵌合，人源化或T细胞表位缺失的抗体变体具有治疗的有利性质 的炎性疾病。
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公开(公告)号：US20120213774A1
公开(公告)日：2012-08-23
申请号：US13402399
申请日：2012-02-22
申请人： Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
发明人： Georg Fertig , Jens Fischer , Guy Georges , Klaus Kaluza , Valeria Lifke , Joerg Moelleken , Sonja Offner , Achal Pashine , Stefan Seeber
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , A61P11/06 , C12N1/21 , C12P21/00 , A61P19/02 , A61P1/04 , C07K16/24 , C12N1/19
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/76 , C07K2317/92
摘要： An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
摘要翻译： 结合IL33R的抗体，其特征在于重链可变结构域包含SEQ ID NO：1的CDR3区，SEQ ID NO：2的CDR2区和SEQ ID NO：3的CDR1区，并且其中轻链可变区 结构域包含SEQ ID NO：4的CDR3区，SEQ ID NO：5的CDR2区和SEQ ID NO：6的CDR1区或嵌合，人源化或T细胞表位缺失的抗体变体具有治疗的有利性质 的炎性疾病。
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公开(公告)号：US09169323B2
公开(公告)日：2015-10-27
申请号：US13582964
申请日：2011-03-03
申请人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
IPC分类号： A61K39/395 , A61K51/10 , A61K39/00 , C07K16/00 , C12P21/08 , A61P35/00 , A61P35/04 , C07K16/28
CPC分类号： C07K16/2866 , A61K47/6849 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US08999327B2
公开(公告)日：2015-04-07
申请号：US12962445
申请日：2010-12-07
申请人： Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Kerstin Krueger
发明人： Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Martin Lanzendoerfer
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CSF-1R（抗CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08900581B2
公开(公告)日：2014-12-02
申请号：US12962445
申请日：2010-12-07
申请人： Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Kerstin Krueger
发明人： Nikolaos Dimoudis , Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Pickl , Carola Ries , Stefan Seeber , Martin Lanzendoerfer
IPC分类号： A61K39/395
摘要： The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US09221910B2
公开(公告)日：2015-12-29
申请号：US13582989
申请日：2011-03-03
申请人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
IPC分类号： A61K39/395 , C07K16/28 , C12N5/12
CPC分类号： C07K16/2866 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CSF-1R（CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20130005949A1
公开(公告)日：2013-01-03
申请号：US13582989
申请日：2011-03-03
申请人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , C12N1/21 , C07K16/30 , C12N5/10 , C12N1/19 , C07K16/46 , C12P21/02
CPC分类号： C07K16/2866 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20120329997A1
公开(公告)日：2012-12-27
申请号：US13582964
申请日：2011-03-03
申请人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
发明人： Georg Fertig , Alexander Fidler , Klaus Kaluza , Marlene Thomas , Carola Ries , Stefan Seeber
CPC分类号： C07K16/2866 , A61K47/6849 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CSF-1R（CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20090191187A1
公开(公告)日：2009-07-30
申请号：US12370628
申请日：2009-02-13
申请人： Ilse Bartke , Francis Carr , Richard Anthony Chizzonite , Elsie M. Eugui , Georg Fertig , Anita Hamilton , Martin Lanzendoerfer , Petra Rueger , Ralf Schumacher , Theresa Patricia Truitt
发明人： Ilse Bartke , Francis Carr , Richard Anthony Chizzonite , Elsie M. Eugui , Georg Fertig , Anita Hamilton , Martin Lanzendoerfer , Petra Rueger , Ralf Schumacher , Theresa Patricia Truitt
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against interleukin-1 receptor (IL-1R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The antibodies of the present invention are particularly useful for treating a variety of inflammatory diseases including, but not limited to, rheumatoid arthritis.
摘要翻译： 本发明涉及抗白细胞介素-1受体（IL-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 本发明的抗体特别可用于治疗各种炎性疾病，包括但不限于类风湿性关节炎。
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公开(公告)号：US06790852B2
公开(公告)日：2004-09-14
申请号：US10408539
申请日：2003-04-07
IPC分类号： A61K31506
CPC分类号： C07D403/04 , C07C45/511 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07C69/708 , C07C303/28 , C07C315/02 , C07C319/14 , C07D405/14 , C07F7/1804 , C07F9/65583 , C07C317/24 , C07C323/22 , C07C323/52 , C07C323/62 , C07C309/66 , C07C309/73
摘要： The invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and related diseases.
摘要翻译： 本发明涉及式（I）化合物，其是用于治疗癌症和相关疾病的有价值的治疗剂。
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