公开(公告)号：US06650729B2

公开(公告)日：2003-11-18

申请号：US10160310

申请日：2002-05-31

申请人： Henning Braess ,  Georg Schmitz ,  Harald Reiter

发明人： Henning Braess ,  Georg Schmitz ,  Harald Reiter

IPC分类号： H05G144

CPC分类号： A61B6/542 ,  A61B6/00

摘要： The invention relates to a method and a device for adapting a radiation dose of an X-ray source (1). The X-ray source (1) irradiates an object to be examined, for example, a patient (4), so as to form an X-ray image (7) on an X-ray detector (5). The X-ray image (7) is subdivided into image regions (A-I) and each time the brightest image region is successively separated from the remaining image regions in an iterative method if its mean grey value forms an indication of the presence of direct radiation (2b) in the relevant image region. The image regions still remaining at the end of the iteration operation correspond to an image region of interest which can be taken into account by a control unit (6) so as to calculate the optimum radiation dose.

摘要翻译： 本发明涉及一种用于调整X射线源（1）的辐射剂量的方法和装置。 X射线源（1）照射被检体，例如患者（4），以在X射线检测器（5）上形成X射线图像（7）。 X射线图像（7）被细分为图像区域（AI），并且每当最亮图像区域以迭代方法与其余图像区域连续分离时，如果其平均灰度值形成直射辐射的存在的指示（ 2b）在相关图像区域。 仍然保持在迭代操作结束的图像区域对应于可以由控制单元（6）考虑的感兴趣的图像区域，以便计算最佳辐射剂量。

公开(公告)号：US06647093B2

公开(公告)日：2003-11-11

申请号：US10084758

申请日：2002-02-25

申请人： Georg Schmitz ,  Henning Braess ,  Harald Reiter

发明人： Georg Schmitz ,  Henning Braess ,  Harald Reiter

IPC分类号： H05G144

CPC分类号： G06K9/32 ,  A61B6/12 ,  A61B6/482 ,  G06K2209/057

摘要： The invention relates to a method and a device for the processing of X-ray images which can be used notably in medical fluoroscopy procedures since they keep the overall radiation load for a patient low. Processing of and detail enhancement in the X-ray images is preferably performed by means of a pattern matching algorithm which necessitates prior knowledge of a pattern of the detail of interest. In order to extract this pattern, at least one single image (HD) is formed (2) with a higher dose rate, said single image having an image quality which suffices for the automatic (4) or non-automatic (3) recognition of the pattern. The information extracted from this single image serves as a basis for the evaluation of X-ray images (LD2) formed with a lower dose rate.

公开(公告)号：US07725163B2

公开(公告)日：2010-05-25

申请号：US10324416

申请日：2002-12-19

申请人： Georg Schmitz ,  Henning Braess ,  Harald Reiter

发明人： Georg Schmitz ,  Henning Braess ,  Harald Reiter

IPC分类号： A61B6/00

CPC分类号： A61B8/08 ,  A61B6/4225 ,  A61B6/4233 ,  A61B6/469 ,  A61B6/503 ,  A61B6/542 ,  A61B8/0883

摘要： An image system, notably an X-ray system and an ultrasound system, is provided in which images or sequences of images are generated and used to automatically change or optimize the operational behavior of individual image system components. Measurement fields are defined in the images of an image sequence by means of a data processing unit. Information is extracted from the measurement fields in order to adapt the system components. More specifically, in the course of a sequence of images the measurement fields are adapted or shifted in conformity with the motion of objects.

摘要翻译： 提供了一种图像系统，特别是X射线系统和超声系统，其中生成图像或序列图像并用于自动改变或优化各个图像系统部件的操作行为。 通过数据处理单元在图像序列的图像中定义测量场。 从测量领域提取信息，以适应系统组件。 更具体地，在图像序列的过程中，测量场被适配或偏移以符合物体的运动。

公开(公告)号：US20070135710A1

公开(公告)日：2007-06-14

申请号：US10578447

申请日：2004-11-04

申请人： Henning Braess

发明人： Henning Braess

IPC分类号： A61B6/00

CPC分类号： A61B6/481 ,  A61B5/02755 ,  A61B6/03 ,  A61B6/037 ,  A61B6/507

摘要： The invention relates to device and a method for determining the concentration of a PET tracer in the blood of a patient (1). With the aid of an X-ray CT (5, 6), first of all the spatial position (r) of a volume element (2) that is filled with blood is determined, which for example can be a part of the aorta or of the left ventricle of the heart. Subsequently, a TOF PET unit that comprises two detector elements (3a, 3b) is set in such a way that it establishes the concentration of the tracer in this volume element (2) and thus in the blood. This value can for example be used within the framework of pharmaco-kinetic examinations which are carried out on the patient (1) with the aid of a three-dimensional PET unit (4).

摘要翻译： 本发明涉及用于确定患者（1）血液中的PET示踪剂的浓度的装置和方法。 借助于X射线CT（5,6），首先确定充满血液的体积元素（2）的空间位置（r），其例如可以是主动脉的一部分，或 的左心室的心脏。 随后，包括两个检测器元件（3a，3b）的TOF PET单元被设置成使得其在该体积元件（2）中建立示踪剂的浓度，从而建立在血液中。 该值可以例如在药物动力学检查的框架内使用，其通过三维PET单元（4）在患者（1）上进行。

公开(公告)号：US07650021B2

公开(公告)日：2010-01-19

申请号：US10578447

申请日：2004-11-04

申请人： Henning Braess

发明人： Henning Braess

IPC分类号： G06K9/00 ,  G01T1/163

CPC分类号： A61B6/481 ,  A61B5/02755 ,  A61B6/03 ,  A61B6/037 ,  A61B6/507

摘要： With the aid of an X-ray CT (5, 6), the spatial position (r) of a body cavity that is filled with blood is determined, which for example can be a part of the aorta or of the left ventricle of the heart of a patient (1). Subsequently, a TOF-PET unit that includes two detector elements (3a, 3b) is positioned to place a predefined volume element (2) in the blood filled body cavity. From pairs of annihilation quanta received from the volume element (2) a concentration of the tracer in this volume element (2) and thus in the blood is determined. This concentration can for example be used within the framework of pharmaco-kinetic examinations which are carried out on the patient (1) with the aid of a three-dimensional PET unit (4).

摘要翻译： 在X射线CT（5,6）的帮助下，确定充满血液的体腔的空间位置（r），其例如可以是主动脉或左心室的一部分 病人的心脏（1）。 随后，包括两个检测器元件（3a，3b）的TOF-PET单元被定位成将预定的体积元件（2）放置在血液填充的体腔中。 从体积元件（2）接收的成对的湮灭量子库中，确定该体积元素（2）中的示踪剂的浓度以及因此在血液中的浓度。 该浓度可以例如在药物动力学检查的框架内使用，其通过三维PET单元（4）在患者（1）上进行。

公开(公告)号：US20080135764A1

公开(公告)日：2008-06-12

申请号：US11805045

申请日：2007-05-22

申请人： Henning Braess

发明人： Henning Braess

IPC分类号： G01T1/02

CPC分类号： A61N5/1048 ,  A61N2005/1052 ,  A61N2005/1087

摘要： A device for locally resolved control of a radiation dose (ρ(γ,e+)({right arrow over (r)})) applied with a pulsed particle beam (6) in particle beam therapy, with a processing unit (24), which is set up to detect continuously a count rate of x-ray quanta (14) measured with a positron emission tomograph (2) and to determine the applied radiation dose (ρρ(γ,e+)({right arrow over (r)})) from the pattern of the measured count rate, by determining by computation from the measured pattern of the count rate the time intervals (In), in which an interaction of the particle beam (6) takes place at the application site and by rejecting these time intervals (In) for the determination of the applied radiation dose (ρ(γ,e+)({right arrow over (r)})).

摘要翻译： 用于在粒子束治疗中施加脉冲粒子束（6）的辐射剂量（rho ^{（γ，e +））（{右箭头（r））的局部解析控制的装置， 单元（24），其被设置为连续检测由正电子发射断层摄影仪（2）测量的x射线量子（14）的计数率，并确定所施加的辐射剂量（rhorho （γ，e + / SUP>（{right arrow over（r））从测量计数率的模式，通过根据测量的计数模式通过计算时间间隔（I> N ）来计算，其中 粒子束（6）的相互作用发生在应用场所，并且通过拒绝这些时间间隔（I N n N）来确定所施加的辐射剂量（rho，γ，e +） （{right arrow over（r））。}

公开(公告)号：US20100016715A1

公开(公告)日：2010-01-21

申请号：US11912678

申请日：2006-04-10

申请人： Daniel Gagnon ,  Henning Braess

发明人： Daniel Gagnon ,  Henning Braess

IPC分类号： A61B6/00

CPC分类号： A61B6/541 ,  A61B5/02755 ,  A61B5/7289 ,  A61B6/037 ,  A61B6/5288 ,  A61B8/5276 ,  A61B8/543

摘要： In a diagnostic imaging system (10), a monitor (50) monitors periodic biological cycles of the subject (14). A trigger point detector (60) detects a time (t1, t2, . . . ,tn) of a common, reoccurring reference point (R1, R2, . . . ,Rn) in each periodic cycle of the subject (14). A sequence selector (62) selects a sequence (64) of nominal sampling segments (Si, S2, . . . ,Sn). An adjustor (70) adjusts duration of each nominal sampling segment (Si, S2, . . . ,Sn) to coincide with the times of detected reference points (R1, R2, . . . ,Rn). A scaling processor (72) scales each adjusted segment based on a difference in duration between the corresponding nominal (Si, S2, . . . Sn) and adjusted sampling segments (S′i, S′2, . . . ,S′n).

摘要翻译： 在诊断成像系统（10）中，监视器（50）监视对象（14）的周期性生物学周期。 触发点检测器（60）检测对象（14）的每个周期循环中的共同的重现的参考点（R1，R2，...，Rn）的时间（t1，t2，...，tn）。 序列选择器（62）选择标称采样段（Si，S2，...，Sn）的序列（64）。 调整器（70）调整每个标称采样段（Si，S2，...，Sn）的持续时间，以与检测到的参考点（R1，R2，...，Rn）的时间一致。 缩放处理器（72）基于相应的标称（Si，S2，... Sn）和调整的采样段（S'i，S'2，...，S'n）之间的持续时间差来缩放每个经调整的段 ）。

公开(公告)号：US07340033B2

公开(公告)日：2008-03-04

申请号：US10566665

申请日：2004-07-19

申请人： Sabine Mollus ,  Jürgen Weese ,  Henning Braess

发明人： Sabine Mollus ,  Jürgen Weese ,  Henning Braess

IPC分类号： G01N23/04

CPC分类号： A61B6/469 ,  A61B6/06 ,  G21K1/02

摘要： The invention relates to a method and a unit for automatically adjusting a collimator (6). In this connection, a region (9) of interest inside the body is determined in an application-specific way from an analysis of first X-ray pictures, and the collimator (6) is then adjusted thereon. The region (9) of interest can, in particular, be chosen to be large enough for the irradiation field to cover all those positions of an organ (10) of interest that occur as a result of heartbeat and/or respiration. Preferably, a movement estimate' is undertaken during a current examination in order to be able to readjust the collimator (6) if necessary. If the region of interest cannot be localized, the collimator (6) is opened to a standard adjustment.

摘要翻译： 本发明涉及一种用于自动调整准直器（6）的方法和单元。 在这方面，通过分析第一X射线照片，以应用特定的方式确定身体内的感兴趣区域（9），然后在其上调整准直器（6）。 特别地，感兴趣的区域（9）可以被选择为足够大以使照射场覆盖作为心跳和/或呼吸的结果而发生的感兴趣的器官（10）的所有位置。 优选地，在当前检查期间进行运动估计，以便能够在必要时重新调整准直器（6）。 如果感兴趣的区域不能被定位，则将准直器（6）打开以进行标准调节。

公开(公告)号：US20070258888A1

公开(公告)日：2007-11-08

申请号：US10579155

申请日：2004-11-09

申请人： Claus Feldmann ,  Henning Braess ,  Joachim Opitz ,  Jacqueline Merikhi

发明人： Claus Feldmann ,  Henning Braess ,  Joachim Opitz ,  Jacqueline Merikhi

IPC分类号： A61K51/12 ,  A61B5/055 ,  A61B8/13 ,  A61K49/04 ,  A61K49/06

CPC分类号： B82Y5/00 ,  A61K49/0002 ,  A61K49/0423 ,  A61K49/0428 ,  A61K49/183 ,  A61K49/1836 ,  A61K49/1875 ,  A61K49/225 ,  A61K51/1251

摘要： A contrast agent for medical imaging techniques is described, comprising particles consisting of at least a core, the core comprising at least an oxide, mixed oxide, or hydroxide of specific elements. The particles optionally comprise shells containing or consisting of precious metal, radioactive isotopes, bio-compatibility agents, and/or antibodies. The applied imaging techniques comprise in particular magnetic resonance tomography (MRI), magnetic particle imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), computed tomography (CT), and ultrasound (US).

摘要翻译： 描述了用于医学成像技术的造影剂，其包括由至少核心组成的颗粒，所述核心包含至少一种特定元素的氧化物，混合氧化物或氢氧化物。 颗粒任选地包含含有或由贵金属，放射性同位素，生物相容剂和/或抗体组成的壳。 所应用的成像技术特别包括磁共振断层摄影（MRI），磁性颗粒成像，正电子发射断层摄影（PET），单光子发射计算机断层摄影（SPECT），计算机断层摄影（CT）和超声波（US）。

公开(公告)号：US20060203966A1

公开(公告)日：2006-09-14

申请号：US10566665

申请日：2004-07-19

申请人： Sabine Mollus ,  Jürgen Weese ,  Henning Braess

发明人： Sabine Mollus ,  Jürgen Weese ,  Henning Braess

IPC分类号： G21K1/04

CPC分类号： A61B6/469 ,  A61B6/06 ,  G21K1/02

摘要： The invention relates to a method and a unit for automatically adjusting a collimator (6). In this connection, a region (9) of interest inside the body is determined in an application-specific way from an analysis of first X-ray pictures, and the collimator (6) is then adjusted thereon. The region (9) of interest can, in particular, be chosen to be large enough for the irradiation field to cover all those positions of an organ (10) of interest that occur as a result of heartbeat and/or respiration. Preferably, a movement estimate' is undertaken during a current examination in order to be able to readjust the collimator (6) if necessary. If the region of interest cannot be localized, the collimator (6) is opened to a standard adjustment.

摘要翻译： 本发明涉及一种用于自动调整准直器（6）的方法和单元。 在这方面，通过分析第一X射线照片，以应用特定的方式确定身体内的感兴趣区域（9），然后在其上调整准直器（6）。 特别地，感兴趣的区域（9）可以被选择为足够大以使照射场覆盖作为心跳和/或呼吸的结果而发生的感兴趣的器官（10）的所有位置。 优选地，在当前检查期间进行运动估计，以便能够在必要时重新调整准直器（6）。 如果感兴趣的区域不能被定位，则将准直器（6）打开以进行标准调节。