-
公开(公告)号：US4232041A
公开(公告)日：1980-11-04
申请号：US50399
申请日：1979-06-20
摘要： Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di-lower alkyl and/or phenyl ether) and water and which have improved stability are obtained by ensuring that such compositions are substantially free of glycols having a molecular weight of less than about 70 and of salts of organic acids. The resulting improved compositions exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding aqueous compositions containing salts of organic acids and/or glycols having a molecular weight of less than about 70.
摘要翻译： 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺，水混溶性有机溶剂如直链聚亚烷基二醇（例如聚乙二醇200）或其醚（例如，单 - 或二 - 低级烷基和/或苯基醚）和水，并且具有改善的稳定性通过确保这些组合物基本上不含分子量小于约70的二醇和有机酸盐获得。 所得到的改进的组合物相对于含有分子量小于约70的有机酸和/或二醇的盐的相应含水组合物表现出降低的卤代酰胺抗微生物的分解速率。
-
公开(公告)号：US4163798A
公开(公告)日：1979-08-07
申请号：US860642
申请日：1977-12-14
摘要： Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di- lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of an aldehyde stabilizer, such as formaldehyde, paraformaldehyde, N-formyl piperidine, vanillin, etc. The compositions so stabilized exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.
摘要翻译： 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺，水混溶性有机溶剂如直链聚亚烷基二醇（例如聚乙二醇200）或其醚（例如，单 - 或二 - 低级烷基和/或苯基醚）和水通过加入醛稳定剂如甲醛，多聚甲醛，N-甲酰基哌啶，香草醛等来稳定，防止卤代酰胺抗微生物分解。如此稳定的组合物表现出降低的速率 相对于相应的非稳定的水性组合物，卤代酰胺的分解可抑制。
-
公开(公告)号：US4163797A
公开(公告)日：1979-08-07
申请号：US860541
申请日：1977-12-14
申请人： George A. Burk , Charles E. Reineke
发明人： George A. Burk , Charles E. Reineke
摘要： Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di-lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of a carbamoyl or sulfamoyl stabilizer, such as dimethyl formamide, sulfamide, urea, oxamide, biuret, caprolactam, succinimide, etc. The compositions, so stabilized, exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.
摘要翻译： 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺，水混溶性有机溶剂如直链聚亚烷基二醇（例如聚乙二醇200）或其醚（例如，单 - 或二 - 低级烷基和/或苯基醚）和水通过加入氨基甲酰基或氨磺酰基稳定剂如二甲基甲酰胺，磺酰胺，脲，草酰胺，缩二脲，己内酰胺，琥珀酰亚胺等来稳定，防止卤代酰胺抗微生物分解。组合物 如此稳定，表现出相对于相应的非稳定水性组合物的卤化酰胺抗微生物分解速率降低。
-
4.发明授权Preparation of cyanoacetamide and 2,2-dibromo-3-nitrilopropionamide compositions 失效氰基乙酰胺和2,2-二溴-3-硝基丙酰胺组合物的制备
公开(公告)号：US4328171A
公开(公告)日：1982-05-04
申请号：US97468
申请日：1979-11-26
IPC分类号： C07C253/30 , A01N37/34 , C07C67/00 , C07C253/00 , C07C255/27 , C07C121/417 , A01N37/18 , C07C120/00
CPC分类号： C07C255/00 , A01N37/34 , Y02P20/125
摘要： An alkyl .alpha.-cyanoacetate is reacted with ammonia in a glycol solvent medium to form cyanoacetamide. Advantageously and without requirement of separation of the formed cyanoacetamide in glycol solvent (even though the next step and entire procedure can optionally commence with pre-formed cyanoacetamide), 2,2-dibromo-3-nitrilopropionamide is formed in situ by treating the cyanoacetamide in glycol with an appropriate mixture of bromine and an alkali metal bromate at about 10.degree. C-40.degree. C. Excellent and stable antimicrobial compositions may then be prepared, as part of an overall integrated process by incorporating in the resultant 2,2-dibromo-3-nitrilopropionamide-containing reaction mass an appropriate quantity of paraformaldehyde or equivalent satisfactory stabilizer at a suitably adjusted pH level.
摘要翻译： 将α-氰基乙酸烷基酯与氨在二醇溶剂介质中反应形成氰基乙酰胺。 有利且不需要在二醇溶剂中分离形成的氰基乙酰胺（即使下一步和整个步骤可以任选地从预形成的氰基乙酰胺开始），2,2-二溴-3-硝基丙酰胺是通过将氰基乙酰胺 乙二醇与溴和碱金属溴酸盐的合适混合物在约10℃-40℃。然后可以制备出优异且稳定的抗微生物组合物，作为总体整合方法的一部分，通过将所得的2,2-二溴 - 含有3-硝基丙酰胺的反应物质适量的多聚甲醛或相当令人满意的稳定剂，在适当调节的pH值下。
-
公开(公告)号：US4190668A
公开(公告)日：1980-02-26
申请号：US860497
申请日：1977-12-14
申请人： George A. Burk , Charles A. Wilson
发明人： George A. Burk , Charles A. Wilson
摘要： Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di- lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of a cyclic ether stabilizer such as tetrahydrofuran, tetrahydropyran, 1,4-dioxane, sym-trioxane, N-methyl morpholine, etc. The compositions, so stabilized, exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.
摘要翻译： 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺，水混溶性有机溶剂如直链聚亚烷基二醇（例如聚乙二醇200）或其醚（例如，单 - 或二 - 低级烷基和/或苯基醚）和水通过加入环醚稳定剂如四氢呋喃，四氢吡喃，1,4-二恶烷，对三异恶烷，N-甲基吗啉等来稳定，防止卤代酰胺抗微生物分解。 如此稳定的组合物相对于相应的非稳定的含水组合物表现出降低的卤化酰胺抗微生物剂的分解速率。
-
公开(公告)号：US4241080A
公开(公告)日：1980-12-23
申请号：US43064
申请日：1979-05-29
申请人： George A. Burk
发明人： George A. Burk
摘要： Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di-lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of an acid or anhydride stabilizer such as acetic acid, glycolic acid, boric acid, ethylenediaminetetraacetic acid, succinic anhydride, etc. The compositions, so stabilized, exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.
摘要翻译： 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺，水混溶性有机溶剂如直链聚亚烷基二醇（例如聚乙二醇200）或其醚（例如，单 - 或二 - 低级烷基和/或苯基醚）和水通过加入酸或酸酐稳定剂如乙酸，乙醇酸，硼酸，乙二胺四乙酸，琥珀酸酐等来稳定，防止卤代酰胺抗微生物分解。 如此稳定，相对于相应的非稳定的含水组合物，表现出降低卤代酰胺抗微生物剂的分解速率。
-
7.发明授权3-((4-(2,2-Dichlor o-1,1-difluoroethoxy)-2-methyl-5-nitrophenyl)sulfonyl)-2-propenenitrile 失效3 - （（4-（2,2-二氯-1,1-二氟乙氧基）-2-甲基-5-硝基苯基）磺酰基）-2-丙烯腈
公开(公告)号：US4093644A
公开(公告)日：1978-06-06
申请号：US770862
申请日：1977-02-22
IPC分类号： C07C317/44 , C07C121/75
CPC分类号： C07C317/44
摘要： The compound 3-((4-(2,2-dichloro-1,1-difluoroethoxy)-2-methyl-5-nitrophenyl)sulfonyl)-2-propenenitrile. The compound has antimicrobial activity.
摘要翻译： 化合物3 - （（4-（2,2-二氯-1,1-二氟乙氧基）-2-甲基-5-硝基苯基）磺酰基）-2-丙烯腈。 该化合物具有抗菌活性。
-
公开(公告)号：US4049695A
公开(公告)日：1977-09-20
申请号：US749483
申请日：1976-12-10
IPC分类号： A01N41/10 , C07C317/14 , C07C121/70
CPC分类号： A01N41/10 , C07C317/00
摘要： 3-((3-(Trifluoromethyl)phenyl)sulfonyl)-2-propenenitrile. The compound has antimicrobial utility.
摘要翻译： 3 - （（3-（三氟甲基）苯基）磺酰基）-2-丙烯腈。 该化合物具有抗菌效用。
-
9.发明授权
公开(公告)号：US4049694A
公开(公告)日：1977-09-20
申请号：US760220
申请日：1977-01-10
IPC分类号： A01N41/10 , C07C317/08 , C07C121/70
CPC分类号： C07C321/00 , A01N41/10
摘要： The title compound is prepared by reacting trichloroethenylthiophenylsulfonyl chloride with acrylonitrile in the presence of a small amount of cupric chloride, acetonitrile and triethylamine hydrochloride, recovering the product from the reaction medium.
摘要翻译： 在少量氯化铜，乙腈和三乙胺盐酸盐的存在下，使三氯乙烯基苯硫酰氯与丙烯腈反应制备标题化合物，从反应介质中回收产物。
-
公开(公告)号：US4163795A
公开(公告)日：1979-08-07
申请号：US860540
申请日：1977-12-14
申请人： George A. Burk
发明人： George A. Burk
摘要： Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di-lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of an azine or nitrile stabilizer, such as s-triazine-2,4,6-triol (i.e., cyanuric acid), 2-chloro-4,6-(ethylamino)-s-triazine, succinonitrile, cyanoguanadine, etc. The compositions, so stabilized, exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.
摘要翻译： 包含卤代酰胺抗微生物剂如2,2-二溴三氟丙酰胺，水混溶性有机溶剂如直链聚亚烷基二醇（例如聚乙二醇200）或其醚（例如，单 - 或二 - 低级烷基和/或苯基醚）和水通过添加吖嗪或腈稳定剂如s-三嗪-2,4,6-三醇（即氰尿酸），2 - 氯-4,6-（乙基氨基）-s-三嗪，丁二腈，氰基胍胺等。如此稳定的组合物相对于相应的非稳定的含水组合物表现出降低卤化酰胺抗微生物剂的分解速率。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.02 秒)