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    Lipid compounds for use in cosmetic products, as food supplement or as a medicament
    4.
    发明授权
    Lipid compounds for use in cosmetic products, as food supplement or as a medicament 有权
    用于化妆品的脂质化合物，作为食品补充剂或药物

    公开(公告)号：US08741966B2

    公开(公告)日：2014-06-03

    申请号：US12741890

    申请日：2008-11-06

    Applicant: Anne Kristin Holmeide

    Inventor： Anne Kristin Holmeide

    IPC: A61K31/095 ,  A61K31/10 ,  A61K31/21 ,  C07C317/08 ,  C07C69/52 ,  C07C321/18 ,  C07C303/00

    CPC classification number: A61K31/00 ,  A23L33/115 ,  A61K8/46 ,  A61K2800/92 ,  A61Q19/06 ,  C07C323/12

    Abstract: The present disclosure relates to lipid compounds of formula (I): wherein: R1 is chosen from a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, and a C10-C21 alkynyl having 1-6 triple bonds; R2 and R3 are the same or different and are chosen from hydrogen and a C1-C6 alkyl; X is chosen from O, S, SO, SO2, Si, and Se; n=1 or 3; and P1 is chosen from hydrogen; a C10-C21 alkyl, a C10-C21 alkenyl having 1-6 double bonds, a C10-C21 alkynyl having 1-6 triple bonds, optionally substituted; a group of formula (II) or formula (III), wherein P2, P3, and P4 are chosen from hydrogen, an alkyl, an alkenyl, and an alkynyl, optionally substituted; and a group of formula (IV) or formula (V), wherein P5 is chosen from hydrogen and a C1-C6 alkyl; or a pharmaceutically acceptable salt, complex, or solvate thereof. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and methods of use thereof, for example in the treatment of diseases related to cardiovascular, metabolic, and inflammatory conditions.

    Abstract translation: 本公开涉及式（I）的脂质化合物：其中：R 1选自C 10 -C 21烷基，具有1-6个双键的C 10 -C 21烯基和具有1-6个三键的C 10 -C 21炔基; R2和R3相同或不同，并且选自氢和C1-C6烷基; X选自O，S，SO，SO2，Si和Se; n = 1或3; P1选自氢; C10-C21烷基，具有1-6个双键的C10-C21烯基，具有1-6个三键的C10-C21炔基，任选取代的; 式（II）或式（III）的基团，其中P2，P3和P4选自氢，烷基，烯基和炔基，任选取代; 和式（IV）或式（V）的基团，其中P 5选自氢和C 1 -C 6烷基; 或其药学上可接受的盐，络合物或溶剂化物。 还公开了包含这些化合物的药物组合物和脂质组合物及其使用方法，例如用于治疗与心血管，代谢和炎性病症有关的疾病。

    Integrin Modulators and Methods for Their Use
    5.
    发明申请
    Integrin Modulators and Methods for Their Use 审中-公开
    整合素调节剂及其使用方法

    公开(公告)号：US20120149940A1

    公开(公告)日：2012-06-14

    申请号：US13371638

    申请日：2012-02-13

    Applicant: John B. Davidson ,  Ali S. Turgiev

    Inventor： John B. Davidson ,  Ali S. Turgiev

    IPC: C07C317/08

    CPC classification number: C07C323/65

    Abstract: 1,5-Dithiaocta-2,7-diene-5-oxide-1-yl (DODOyl) compounds and derivatives thereof, referred to collectively as DODOyl-derived compounds (DDCs), and chiral enantiomers and derivatives thereof, are described, which are integrin modulators that modulate integrin-mediated functions and/or processes. Pharmaceutical compositions containing integrin modulators and chiral enantiomers thereof, and methods for using integrin modulators and chiral enantiomers thereof are further described.

    Abstract translation: 描述了共称为DODOyl衍生化合物（DDC）的1,5-二硫杂-2,7-二烯-5-氧化物-1-基（DODOyl）化合物及其衍生物及其手性对映异构体及其衍生物，其中 是整合素调节剂，其调节整联蛋白介导的功能和/或过程。 进一步描述了含有整联蛋白调节剂及其手性对映异构体的药物组合物，以及使用整联蛋白调节剂及其手性对映异构体的方法。

    Organosulfur Compounds, a Method of Making Organosulfur Compounds and their Use for Inhibiting the Growth of Tumour Cells
    6.
    发明申请
    Organosulfur Compounds, a Method of Making Organosulfur Compounds and their Use for Inhibiting the Growth of Tumour Cells 失效
    有机硫化合物，一种制备有机硫化合物的方法及其用于抑制肿瘤细胞生长的方法

    公开(公告)号：US20110190368A1

    公开(公告)日：2011-08-04

    申请号：US13057960

    申请日：2009-08-05

    Applicant: Catherine Hart Kaschula ,  Roger Hunter ,  Mohamed Iqbal Parker

    Inventor： Catherine Hart Kaschula ,  Roger Hunter ,  Mohamed Iqbal Parker

    IPC: A61K31/40 ,  C07C317/08 ,  A61K31/105 ,  C07C327/00 ,  A61K31/21 ,  C07D209/48 ,  C07C311/00 ,  A61K31/18 ,  A61P35/00

    CPC classification number: A61K31/105 ,  A61K31/18 ,  A61K31/4035 ,  C07C323/65 ,  C07D209/48

    Abstract: Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumour cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.

    Abstract translation: 描述了通式（2）的有机硫化合物，其中R 1和R 2是直链或支链C 1 -C 5烷基; 直链或支链C 1 -C 5烯基，条件是R 1不是丙-1-烯基（烯丙基）; 取代的直链或支链C 1 -C 5烯基或取代的直链或支链C 1 -C 5烷基，其中取代基选自OR 3，NR 4 R 5，COOR 6，CON-R 7 R 8，其中R 3选自H，COR 9，对甲氧基苄基和三烷基甲硅烷基 其中R9是烷基或取代的烷基; R4N和R5是烷基或R4和R5一起形成苯二甲酰亚氨基; R6是烷基或取代的烷基; 并且R 7和R 8是烷基或取代的烷基; 取代或未取代的芳族化合物，其中R 1和R 2是苄基，对甲氧基苄基和/或邻甲氧基苄基和取代或未取代的杂芳族。 该化合物可用于抑制肿瘤细胞的生长和治疗癌症。 还描述了药物组合物和制备该化合物的方法。

    Sulphones
    10.
    发明授权
    Sulphones 失效
    手机

    公开(公告)号：US4048234A

    公开(公告)日：1977-09-13

    申请号：US413246

    申请日：1973-11-06

    Applicant: Pierre Chabardes ,  Marc Julia ,  Albert Menet

    Inventor： Pierre Chabardes ,  Marc Julia ,  Albert Menet

    IPC: C07C315/00 ,  C07C67/00 ,  C07C313/00 ,  C07C315/04 ,  C07C317/00 ,  C07C317/02 ,  C07C317/08 ,  C07C317/10 ,  C07C317/14 ,  C07C317/18 ,  C07C317/24 ,  C07C401/00 ,  C07C403/00 ,  C07C403/22 ,  C07C403/24 ,  C07C147/06

    CPC classification number: C07C403/24 ,  C07C317/14 ,  C07C317/24 ,  C07C403/22 ,  C07C2101/16 ,  Y10S585/934 ,  Y10S585/935

    Abstract: Sulphones of the formula: ##STR1## in which R is a substituted or unsubstituted alkyl, alkylaryl, aralkyl, or aryl radical, A is a radical containing one or more isoprene units which is saturated, unsaturated, or of the conjugated or unconjugated polyene type, which is unsubstituted or substituted by one or more functional groups, halogen atoms or alkyl groups, and which may be cyclic when the number of isoprene units is at least 2, and Q is hydrogen or a cyclic or acyclic hydrocarbon radical which is saturated, unsaturated, or of the conjugated or unconjugated polyene type, and which is unsubstituted or substituted by one or more functional groups, halogen atoms or alkyl groups are useful intermediates in the production of terpene compounds such as .beta.-carotene and canthaxanthine.

    Abstract translation: 其中R是取代或未取代的烷基，烷基芳基，芳烷基或芳基，A是含有一个或多个饱和，不饱和或共轭或未共轭多烯型异戊二烯单元的基团的式 其是未取代的或被一个或多个官能团取代的卤素原子或烷基，并且当异戊二烯单元的数目为至少2时可以是环状的，并且Q是氢或饱和的环状或非环状烃基， 不饱和或共轭或非共轭多烯型，其未被取代或被一个或多个官能团取代，卤素原子或烷基是制备萜烯化合物如β-胡萝卜素和角黄素的有用的中间体。

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