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    Omega-3 fatty acids and dyslipidemic agent for lipid therapy
    1.
    发明申请
    Omega-3 fatty acids and dyslipidemic agent for lipid therapy 审中-公开
    欧米加-3脂肪酸和血脂异常剂用于脂质治疗

    公开(公告)号：US20060211762A1

    公开(公告)日：2006-09-21

    申请号：US11284095

    申请日：2005-11-22

    申请人： Roelof Rongen ,  George Bobotas ,  Egil Bodd ,  Hogne Vik

    发明人： Roelof Rongen ,  George Bobotas ,  Egil Bodd ,  Hogne Vik

    IPC分类号： A61K31/401 ,  A61K31/366 ,  A61K31/22 ,  A61K31/202

    CPC分类号： A61K31/202 ,  A61K31/22 ,  A61K31/232 ,  A61K31/351 ,  A61K31/366 ,  A61K31/401 ,  A61K31/426 ,  A61K2300/00

    摘要： A method and composition for blood lipid therapy by administering to the subject an effective amount of a dyslipidemic agent and omega-3 fatty acids. The method utilizes a single administration or a unit dosage of a combination of dyslipidemic agent and omega-3 fatty acids for the treatment of patients with hypertriglyceridemia, hypercholesterolemia, mixed dyslipidemia, coronary heart disease (CHD), vascular disease, artherosclerotic disease and related conditions, and the prevention or reduction of cardiovascular and vascular events.

    摘要翻译： 一种用于血脂治疗的方法和组合物，其通过向受试者施用有效量的血脂异常剂和ω-3脂肪酸。 该方法利用单次给药或单位剂量的血脂异常剂和ω-3脂肪酸的组合来治疗高甘油三酯血症，高胆固醇血症，混合性血脂异常，冠心病（CHD），血管疾病，动脉粥样硬化疾病和相关病症 ，以及预防或减少心血管和血管事件。

    STATIN AND OMEGA-3 FATTY ACIDS FOR LIPID THERAPY
    2.
    发明申请
    STATIN AND OMEGA-3 FATTY ACIDS FOR LIPID THERAPY 审中-公开
    脯氨酸和OMEGA-3脂肪酸用于脂质治疗

    公开(公告)号：US20070191467A1

    公开(公告)日：2007-08-16

    申请号：US11742292

    申请日：2007-04-30

    申请人： Roelof Rongen ,  George Bobotas ,  Egil Bodd ,  Hogne Vik

    发明人： Roelof Rongen ,  George Bobotas ,  Egil Bodd ,  Hogne Vik

    IPC分类号： A61K31/401 ,  A61K31/366 ,  A61K31/22 ,  A61K31/202

    CPC分类号： A61K31/366 ,  A61K31/202 ,  A61K31/22 ,  A61K31/232 ,  A61K31/351 ,  A61K31/40 ,  A61K31/401 ,  A61K2300/00

    摘要： A method of lipid therapy, comprising providing a subject group having a baseline triglyceride level of 200 to 499 mg/dl and being at or near its low-density lipoprotein cholesterol (LDL-C) level goal, and reducing the triglyceride level and the non-high-density lipoprotein cholesterol (non-HDL-C) level of the subject group as compared to treatment with a 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) inhibitor alone, by administering to the subject group an effective amount of an HMG CoA inhibitor and a composition comprising omega-3 fatty acids.

    摘要翻译： 一种脂质治疗方法，包括提供具有200至499mg / dl的基线甘油三酯水平并且处于或接近其低密度脂蛋白胆固醇（LDL-C）水平目标的受试者组，并且降低甘油三酯水平和非 - 与单独使用3-羟基-3-甲基戊二酰辅酶A（HMG CoA）抑制剂的治疗相比，本发明组的高密度脂蛋白胆固醇（非HDL-C）水平通过向受试者组施用有效量 的HMG CoA抑制剂和包含ω-3脂肪酸的组合物。

    Treatment with omega-3 fatty acids and PPAR agonist and/or antagonist and a combination product thereof
    5.
    发明申请
    Treatment with omega-3 fatty acids and PPAR agonist and/or antagonist and a combination product thereof 审中-公开
    用ω-3脂肪酸和PPAR激动剂和/或拮抗剂及其组合产物治疗

    公开(公告)号：US20060211749A1

    公开(公告)日：2006-09-21

    申请号：US11293513

    申请日：2005-12-05

    申请人： George Bobotas ,  Robert Shalwitz ,  Roelof Rongen

    发明人： George Bobotas ,  Robert Shalwitz ,  Roelof Rongen

    IPC分类号： A61K31/426 ,  A61K31/22 ,  A61K31/202 ,  A61K31/192

    CPC分类号： A61K31/426 ,  A61K31/192 ,  A61K31/202 ,  A61K31/22 ,  A61K45/06 ,  A61K2300/00

    摘要： A method and composition for blood lipid therapy that comprises administering to the subject an effective amount of a PPAR agonist and/or antagonist and an omega-3 fatty acid. The methods and compositions include combination products or concomitant therapy for the treatment of subjects with hypertriglyceridemia, hypercholesteremia, mixed dyslipidemia, vascular disease, artherosclerotic disease and related conditions, obesity, the prevention or reduction of cardiovascular and vascular events, the reduction of insulin resistance, fasting glucose levels and postprandial glucose levels, and/or the reduction of incidence and/or the delay of onset of diabetes.

    摘要翻译： 一种用于血脂治疗的方法和组合物，其包括向受试者施用有效量的PPAR激动剂和/或拮抗剂和ω-3脂肪酸。 所述方法和组合物包括用于治疗患有高甘油三酯血症，高胆固醇血症，混合性血脂异常，血管疾病，动脉粥样硬化疾病和相关病症，肥胖症，预防或减少心血管和血管事件，降低胰岛素抵抗的组合产品或伴随治疗， 空腹血糖水平和餐后葡萄糖水平，和/或糖尿病发病率和/或延迟发作的降低。

    STATIN AND OMEGA-3 FATTY ACIDS FOR LIPID THERAPY
    6.
    发明申请
    STATIN AND OMEGA-3 FATTY ACIDS FOR LIPID THERAPY 审中-公开
    脯氨酸和OMEGA-3脂肪酸用于脂质治疗

    公开(公告)号：US20110092563A1

    公开(公告)日：2011-04-21

    申请号：US12977109

    申请日：2010-12-23

    申请人： George Bobotas ,  Roelof M. L. Rongen ,  Egil Bodd ,  Hogne Vik

    发明人： George Bobotas ,  Roelof M. L. Rongen ,  Egil Bodd ,  Hogne Vik

    IPC分类号： A61K31/40 ,  A61K31/20 ,  A61K31/23 ,  A61K31/351 ,  A61P3/06 ,  A61P9/00

    CPC分类号： A61K31/40 ,  A61K31/202 ,  A61K31/22 ,  A61K31/232 ,  A61K31/351 ,  A61K31/366 ,  A61K31/401 ,  A61K45/06 ,  A61K2300/00

    摘要： A method of lipid therapy, comprising providing a subject group having a baseline triglyceride level of 200 to 499 mg/dl and being at or near its low-density lipoprotein cholesterol (LDL-C) level goal, and reducing the triglyceride level and the non-high-density lipoprotein cholesterol (non-HDL-C) level of the subject group as compared to treatment with a 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) inhibitor alone, by administering to the subject group an effective amount of an HMG CoA inhibitor and a composition comprising omega-3 fatty acids.

    摘要翻译： 一种脂质治疗方法，包括提供具有200至499mg / dl的基线甘油三酯水平并且处于或接近其低密度脂蛋白胆固醇（LDL-C）水平目标的受试者组，并且降低甘油三酯水平和非 - 与单独使用3-羟基-3-甲基戊二酰辅酶A（HMG CoA）抑制剂的治疗相比，本发明组的高密度脂蛋白胆固醇（非HDL-C）水平通过向受试者组施用有效量 的HMG CoA抑制剂和包含ω-3脂肪酸的组合物。

    Treating morning hypertension by lowering morning blood pressure levels with propranolol
    7.
    发明申请
    Treating morning hypertension by lowering morning blood pressure levels with propranolol 审中-公开
    通过用普萘洛尔降低早晨血压水平治疗早晨高血压

    公开(公告)号：US20060069165A1

    公开(公告)日：2006-03-30

    申请号：US11048052

    申请日：2005-02-02

    申请人： Keith Rotenberg ,  George Bobotas

    发明人： Keith Rotenberg ,  George Bobotas

    IPC分类号： A61K31/137

    CPC分类号： A61K31/137

    摘要： This invention relates to a method and kit having a composition for reducing morning blood pressure levels (for treating morning hypertension). Pursuant to this method, a therapeutic amount of β-adrenergic-blocking agent is administered nightly to a person that suffers from blood pressure level attacks such that the blocking agent is released during morning hours when the person is most susceptible to a raised blood pressure level. The kit includes a composition having the therapeutic amount of β-adrenergic-blocking agent that is control released and instructions for administering the composition in evening hours.

    摘要翻译： 本发明涉及具有降低早晨血压水平的组合物（用于治疗早晨高血压）的方法和试剂盒。 根据该方法，将治疗量的β-肾上腺素能阻断剂每夜施用于患有血压水平发作的人，使得阻断剂在早晨释放时，该人最容易受到升高的血压水平的影响 。 试剂盒包括具有控制释放的治疗量的β-肾上腺素能阻断剂的组合物和在晚上时间施用该组合物的说明书。