公开(公告)号：US20060223825A1

公开(公告)日：2006-10-05

申请号：US11376432

申请日：2006-03-15

申请人： George Chiu ,  Shengjian Li ,  Peter Connolly ,  Virginia Pulito ,  Jingchun Liu ,  Steven Middleton

发明人： George Chiu ,  Shengjian Li ,  Peter Connolly ,  Virginia Pulito ,  Jingchun Liu ,  Steven Middleton

IPC分类号： A61K31/496 ,  C07D403/04

CPC分类号： C07D213/74

摘要： The present invention relates to piperazine substituted cyclohexane- 1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as methods of treatment.

摘要翻译： 本发明涉及式（I）的哌嗪取代的环己烷-1,4-二胺化合物及其药学上可接受的形式，作为α1a1/α1D1肾上腺素受体调节剂 治疗良性前列腺肥大和下尿路症状。 本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

公开(公告)号：US20060217419A1

公开(公告)日：2006-09-28

申请号：US11376348

申请日：2006-03-15

申请人： George Chiu ,  Shengjian Li ,  Peter Connolly ,  Virginia Pulito ,  Jingchun Liu ,  Steven Middleton

发明人： George Chiu ,  Shengjian Li ,  Peter Connolly ,  Virginia Pulito ,  Jingchun Liu ,  Steven Middleton

IPC分类号： A61K31/454 ,  A61K31/445 ,  C07D401/02 ,  C07D211/26

CPC分类号： C07D211/14 ,  C07D211/22 ,  C07D405/12

摘要： The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.

摘要翻译： 本发明涉及式（I）的哌啶取代的环己烷-1,4-二胺化合物及其药学上可接受的形式，作为α1a1/α1d1肾上腺素受体调节剂 治疗良性前列腺肥大和下尿路症状。 本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

公开(公告)号：US07470711B2

公开(公告)日：2008-12-30

申请号：US11376348

申请日：2006-03-15

申请人： George Chiu ,  Shengjian Li ,  Peter J. Connolly ,  Virginia L. Pulito ,  Jingchun Liu ,  Steven A. Middleton

发明人： George Chiu ,  Shengjian Li ,  Peter J. Connolly ,  Virginia L. Pulito ,  Jingchun Liu ,  Steven A. Middleton

IPC分类号： A61K31/451 ,  A61K31/453 ,  C07D211/22 ,  C07D405/12

CPC分类号： C07D211/14 ,  C07D211/22 ,  C07D405/12

摘要： The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.

摘要翻译： 本发明涉及用于治疗良性前列腺肥大和下尿路症状的α1a/α1d肾上腺素受体调节剂的式（I）的哌啶取代的环己烷-1,4-二胺化合物及其药学上可接受的形式。 本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。

公开(公告)号：US07482348B2

公开(公告)日：2009-01-27

申请号：US11376432

申请日：2006-03-15

申请人： George Chiu ,  Shengjian Li ,  Peter J. Connolly ,  Virginia L. Pulito ,  Jingchun Liu ,  Steven A. Middleton

发明人： George Chiu ,  Shengjian Li ,  Peter J. Connolly ,  Virginia L. Pulito ,  Jingchun Liu ,  Steven A. Middleton

IPC分类号： A61K31/496 ,  C07D213/74

CPC分类号： C07D213/74

摘要： The present invention relates to piperazine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as methods of treatment.

摘要翻译： 本发明涉及用于治疗良性前列腺肥大和下尿路症状的α1a/α1d肾上腺素受体调节剂的式（I）的哌嗪取代的环己烷-1,4-二胺化合物及其药学上可接受的形式。 本发明还涉及包含所述新化合物的药物组合物，制备这些新化合物的新方法和作为药物的新用途以及治疗方法。