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    Methods of reducing the perception of body odors with olfactory adaptation and cross-adapting agents
    3.
    发明申请
    Methods of reducing the perception of body odors with olfactory adaptation and cross-adapting agents 审中-公开
    减少嗅觉适应和交叉适应剂对身体气味的感知的方法

    公开(公告)号：US20070020210A1

    公开(公告)日：2007-01-25

    申请号：US11514032

    申请日：2006-08-30

    申请人： George Preti ,  Charles Wysocki ,  Leslie Smith ,  Keith McDermott

    发明人： George Preti ,  Charles Wysocki ,  Leslie Smith ,  Keith McDermott

    IPC分类号： A61K8/28

    CPC分类号： A61K8/34 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/4973 ,  A61K8/498 ,  A61Q15/00

    摘要： Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

    摘要翻译： 公开的除臭剂组合物包含与有效减少恶臭感的量单独或与其它此类试剂组合的交叉适应剂。 还公开了除臭剂组合物，其包含与有效降低对性别特异性恶臭感觉的量单独或与其它此类试剂组合的交叉适应剂。 所述方法的特征在于减少感觉到的身体气味，包括施用除臭剂组合物，其中所述组合物包含一定量的有效减少对这种气味的感知的交叉适应剂。 其他方法特征是阻止感觉到的身体气味，包括施用除臭剂组合物，其中组合物包含有效占据加味剂受体位点的量的交叉适应剂，从而阻止位点与其它气味剂的相互作用。 还提供了制备除臭剂组合物的方法，其中单独或与其它此类试剂组合的交叉适应剂以有效减少恶臭感的量包括在内。

    Olfactory adaptation and cross-adapting agents to reduce the perception of body odors
    4.
    发明授权
    Olfactory adaptation and cross-adapting agents to reduce the perception of body odors 有权
    嗅觉适应和交叉适应剂减少人体气味的感觉

    公开(公告)号：US07763238B2

    公开(公告)日：2010-07-27

    申请号：US10342626

    申请日：2003-01-15

    申请人： George Preti ,  Charles J. Wysocki ,  Leslie C. Smith ,  Keith J. McDermott

    发明人： George Preti ,  Charles J. Wysocki ,  Leslie C. Smith ,  Keith J. McDermott

    IPC分类号： A61Q15/00 ,  A61K8/00 ,  A61K8/18 ,  A61Q13/00

    CPC分类号： A61K8/34 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/4973 ,  A61K8/498 ,  A61Q15/00

    摘要： Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

    摘要翻译： 公开的除臭剂组合物包含与有效减少恶臭感的量单独或与其它此类试剂组合的交叉适应剂。 还公开了除臭剂组合物，其包含与有效降低对性别特异性恶臭感觉的量单独或与其它此类试剂组合的交叉适应剂。 所述方法的特征在于减少感觉到的身体气味，包括施用除臭剂组合物，其中所述组合物包含一定量的有效减少对这种气味的感知的交叉适应剂。 其他方法特征是阻止感觉到的身体气味，包括施用除臭剂组合物，其中组合物包含有效占据加味剂受体位点的量的交叉适应剂，从而阻止位点与其它气味剂的相互作用。 还提供了制备除臭剂组合物的方法，其中单独或与其它此类试剂组合的交叉适应剂以有效减少恶臭感的量包括在内。

    Axillary androstenol and dehydroepiandrosterone as fertile period onset indicators
    5.
    发明授权
    Axillary androstenol and dehydroepiandrosterone as fertile period onset indicators 失效
    脯氨酸和脱水表雄酮作为生育期发病指标

    公开(公告)号：US4931403A

    公开(公告)日：1990-06-05

    申请号：US390156

    申请日：1989-08-07

    申请人： Winnifred B. Cutler ,  George Preti ,  George R. Huggins

    发明人： Winnifred B. Cutler ,  George Preti ,  George R. Huggins

    IPC分类号： G01N33/74

    CPC分类号： G01N33/743 ,  Y10S436/906 ,  Y10T436/146666

    摘要： A novel method of determining the onset of the fertile period of a human female is disclosed comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating the onset of the fertile period at a time when appropriate contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.

    摘要翻译： 公开了一种确定人类雌性可育期发病的新方法，包括在月经周期中监测所述雌性腋窝分泌物的步骤，以确定硫氨酸或脱氢表雄酮硫酸盐浓度的变化。 月经停止后，这些化合物中的任一种的浓度首次显着增加，表明可育期的开始。 在每种情况下，发生卵泡相峰，其超过在月经周期期间的任何其他时间存在的那些化合物的浓度的至少两倍。 因此，这些化合物的监测可以作为预测五至七天排卵发生的可靠指标，和/或表示在仍然可以采取适当的避孕措施避免怀孕或/或 性交可以促进生育。

    Birth control method involving monitoring of axillary androstenol and dehydroepiandrosterone
    6.
    发明授权
    Birth control method involving monitoring of axillary androstenol and dehydroepiandrosterone 失效
    妊娠控制方法包括监测腋生和前列醇和脱氢表雄酮

    公开(公告)号：US4879244A

    公开(公告)日：1989-11-07

    申请号：US005240

    申请日：1987-01-20

    申请人： Winnifred B. Cutler ,  George Preti ,  George R. Huggins

    发明人： Winnifred B. Cutler ,  George Preti ,  George R. Huggins

    IPC分类号： G01N33/74

    CPC分类号： G01N33/743 ,  Y10T436/146666

    摘要： A novel method of determining the onset of the fertile period of a human female is disclosed comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.

    摘要翻译： 公开了一种确定人类雌性可育期发病的新方法，包括在月经周期中监测所述雌性腋窝分泌物的步骤，以确定硫氨酸或脱氢表雄酮硫酸盐浓度的变化。 月经停止后，这些化合物中的任一种的浓度首次显着增加，表明可育期的开始。 在每种情况下，发生卵泡相峰，其超过在月经周期期间的任何其他时间存在的那些化合物的浓度的至少两倍。 因此，这些化合物的监测可以作为预测五至七天排卵发生的可靠指标，和/或表明仍可采取避孕措施以避免怀孕或性交可促进生育。

    OLFACTORY ADAPTATION AND CROSS-ADAPTING AGENTS TO REDUCE THE PERCEPTION OF BODY ODORS
    9.
    发明申请
    OLFACTORY ADAPTATION AND CROSS-ADAPTING AGENTS TO REDUCE THE PERCEPTION OF BODY ODORS 审中-公开
    OLFACTORY适应和交叉适应剂减少身体气味的感觉

    公开(公告)号：US20100254927A1

    公开(公告)日：2010-10-07

    申请号：US12816717

    申请日：2010-06-16

    申请人： George Preti ,  Charles J. Wysocki ,  Leslie C. Smith ,  Keith J. McDermott

    发明人： George Preti ,  Charles J. Wysocki ,  Leslie C. Smith ,  Keith J. McDermott

    IPC分类号： A61K8/30 ,  A61Q15/00

    CPC分类号： A61K8/34 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/4973 ,  A61K8/498 ,  A61Q15/00

    摘要： Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

    摘要翻译： 公开的除臭剂组合物包含与有效减少恶臭感的量单独或与其它此类试剂组合的交叉适应剂。 还公开了除臭剂组合物，其包含与有效降低对性别特异性恶臭感觉的量单独或与其它此类试剂组合的交叉适应剂。 所述方法的特征在于减少感觉到的身体气味，包括施用除臭剂组合物，其中所述组合物包含一定量的有效减少对这种气味的感知的交叉适应剂。 其他方法特征是阻止感觉到的身体气味，包括施用除臭剂组合物，其中组合物包含有效占据加味剂受体位点的量的交叉适应剂，从而阻止位点与其它气味剂的相互作用。 还提供了制备除臭剂组合物的方法，其中单独或与其它此类试剂组合的交叉适应剂以有效减少恶臭感的量包括在内。

    Use of male essence to alter female endocrine response
    10.
    发明授权
    Use of male essence to alter female endocrine response 失效
    使用男性精华改变女性内分泌反应

    公开(公告)号：US5155045A

    公开(公告)日：1992-10-13

    申请号：US857935

    申请日：1986-04-30

    申请人： Winnifred B. Cutler ,  George Preti ,  Celso R. Garcia

    发明人： Winnifred B. Cutler ,  George Preti ,  Celso R. Garcia

    IPC分类号： A61K31/565

    CPC分类号： A61K31/565 ,  Y10S436/817 ,  Y10S436/906 ,  Y10T436/200833 ,  Y10T436/203332

    摘要： A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This exposure is preferably continued in amounts and for a duration which are effective to significantly alter an endocrine related characteristic, such as the menstrual cycle length, of that female. In particular, the portions of male axillary secretions to be exposed to the female preferably comprise one or more compounds such as androstenol, dehydroepiandrosterone, and/or a compound or compounds exhibiting a burnt heavy axiallary-like odor which elutes at about 50 minutes as shown on the FID response curve of FIG. 3B. Studies show that pooled male donor secretions are effective to alter aberrant menstrual cycles, particularly those exhibiting luteal phase defects such that they become presumptively fertile menstrual cycles having durations of about 29.5.+-.3 days. Symptoms of perimenopause, such as hot flashes, night sweats and irregular menstrual cycles, are also treatable using the methods of this invention, which tend to promote female endocrine regularity and longevity.

    摘要翻译： 公开了一种治疗人类雌性的新方法，其包括将所述雌性的鼻腔暴露于人雄性的至少一部分腋窝分泌物的步骤。 这种暴露优选以有效显着改变该女性的内分泌相关特征（例如月经周期长度）的量和持续时间持续。 特别地，暴露于雌性的男性腋窝分泌物的部分优选包含一种或多种化合物，例如雄蕊醇，脱氢表雄酮和/或显示烧焦的重轴向样气味的化合物或化合物，其如图所示在约50分钟洗脱 在图1的FID响应曲线上。 3B。 研究表明，合并的雄性供体分泌物可有效改变异常月经周期，特别是那些呈现黄体期缺陷的那些，使得它们被假定为具有约29.5 +/- 3天持续时间的肥沃的月经周期。 围绝经期的症状，如潮热，盗汗和不规律的月经周期，也可使用本发明的方法治疗，这倾向于促进女性的内分泌规律性和长寿。