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    Oral osmotic device with hydrogel driving member
    7.
    发明授权
    Oral osmotic device with hydrogel driving member 失效
    具有水凝胶驱动构件的口腔渗透装置

    公开(公告)号：US5248310A

    公开(公告)日：1993-09-28

    申请号：US859191

    申请日：1992-03-27

    申请人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri D. Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    发明人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri D. Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译： 公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。 装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。 装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层 可溶胀的亲水性聚合物。 壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。 所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。 在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。 壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。 标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。

    Oral osmotic device for delivery of nystatin with hydrogel driving member
    10.
    发明授权
    Oral osmotic device for delivery of nystatin with hydrogel driving member 失效
    口服渗透装置用于用水凝胶驱动构件递送制霉菌素

    公开(公告)号：US5776493A

    公开(公告)日：1998-07-07

    申请号：US171875

    申请日：1993-12-22

    申请人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    发明人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    IPC分类号： A61K9/00 ,  A61K9/52 ,  A61K9/24

    CPC分类号： A61K9/0004

    摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译： 公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。 装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。 装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层 可溶胀的亲水性聚合物。 壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。 所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。 在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。 壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。 标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。