利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

25 条记录 (耗时 0.029 秒)

    Pyrazine derivatives, their preparation and medicaments containing them
    2.
    发明授权
    Pyrazine derivatives, their preparation and medicaments containing them 失效
    吡嗪衍生物，其制剂和含有它们的药物

    公开(公告)号：US06399613B1

    公开(公告)日：2002-06-04

    申请号：US09483984

    申请日：2000-01-14

    申请人： Georges Bashiardes ,  Jean-Christophe Carry ,  Michel Evers ,  Bruno Filoche ,  Serge Mignani

    发明人： Georges Bashiardes ,  Jean-Christophe Carry ,  Michel Evers ,  Bruno Filoche ,  Serge Mignani

    IPC分类号： A61K3150

    CPC分类号： C07D213/81 ,  C07D213/38 ,  C07D213/82 ,  C07D241/12 ,  C07D241/24

    摘要： The invention concerns pyrazine derivatives of formula (1) in which a pharmaceutical composition comprising at least one compound of formula: in which R represents a nitrogen atom, R1 and R3 each represent the same radical selected from the group consisting of —CO—NR5R6, —CO—N(CH(CH2OH)2)2, —CO—N(CH2OH)2, —CO—N(CH2—CH(CH2OH)2)2, —CO—N(CH2—(CHOH)n—CH2OH)2 in which n is equal to 0, 1, 2, 3 or 4, —CH2—O—R6, —NR5—CO—R6, —CH2—NR5R6, —CH2—N(CH2OH)2, —CH2—N(CH2—(CHOH)y—CH2OH)2 in which y is equal to 0, 1, 2, 3 or 4, —CH2—N(CH(CH2OH)2)2 and —CH2—N(CH2—CH(CH2OH)2)2 and R2 and R4 each represents a hydrogen atom, R5 represents a hydrogen atom or an alkyl radical, R6 represents a radical —CH2—(CHOH)m—CH2OH in which m is equal to 0, 1, 2, 3 or 4, -alk-O-alk-CH2OH, -alk-O-alk, —CH(CH2OH)2, —C(CH2OH)3, —C(CH3) (CH2OH)2, —CH2—CH(CH2OH)2 or —CH(CH2OH)—(CHOH)x—CH2OH in which x is equal to 1, 2, 3 or 4, alk represents an alkyl radical, the alkyl radicals containing, unless otherwise stated, 1 to 6 carbon atoms in a straight or branched chain, stereoisomers thereof and salts thereof with an inorganic or organic acid and their preparation.

    摘要翻译： 本发明涉及式（1）的吡嗪衍生物，其中包含至少一种下式的化合物的药物组合物：其中R表示氮原子，R1和R3各自表示选自-CO-NR5R6， - CO-N（CH（CH 2 OH）2）2，-CO-N（CH 2 OH）2，-CO-N（CH 2 -CH（CH 2 OH）2）2，-CO-N（CH 2 - （CHOH）n -CH 2 OH） 2，其中n等于0,1,2,3或4，-CH 2 -O-R 6，-NR 5 -CO-R 6，-CH 2 -NR 5 R 6，-CH 2 -N（CH 2 OH）2，-CH 2 -N（ CH 2 - （CHOH）y -CH 2 OH）2，其中y等于0,1,2,3或4，-CH 2 -N（CH（CH 2 OH）2）2和-CH 2 -N（CH 2 -CH（CH 2 OH） 2）2，R 2和R 4各自表示氢原子，R 5表示氢原子或烷基，R 6表示基团-CH 2 - （CHOH）m -CH 2 OH，其中m等于0,1,2,3或 4，-alk-O-烷基-CH 2 OH，-OCO-烷基，-CH（CH 2 OH）2，-C（CH 2 OH）3，-C（CH 3）（CH 2 OH）2，-CH 2 -CH（CH 2 OH）2 或-CH（CH 2 OH） - （CHOH）x-CH 2 OH，其中x等于1,2,3或4，alk表示烷基，除非另有说明，烷基含有1至6个碳原子 其直链或支链的立体异构体和其与无机或有机酸的盐及其制备方法。

    Polyhydroxyalkylpyrazine derivatives, their preparation and the medicaments comprising them
    7.
    发明授权
    Polyhydroxyalkylpyrazine derivatives, their preparation and the medicaments comprising them 有权
    聚羟基烷基吡嗪衍生物，其制备方法和包含它们的药物

    公开(公告)号：US06362185B1

    公开(公告)日：2002-03-26

    申请号：US09483939

    申请日：2000-01-14

    申请人： Georges Bashiardes ,  Jean-Christophe Carry ,  Michel Evers ,  Bruno Filoche ,  Serge Mignani

    发明人： Georges Bashiardes ,  Jean-Christophe Carry ,  Michel Evers ,  Bruno Filoche ,  Serge Mignani

    IPC分类号： A61K314965

    CPC分类号： A61K31/495 ,  C07D241/12

    摘要： The present invention relates to medicaments comprising at least one compound of formula: wherein either R1 represents a —CH(Ra)—CHOH—CHOH—CH2OH chain and R2 represents a —CH2—CHOH—CHOH—CH2OH chain, or R1 represents a —CHOH—CHF—CHOH—CH2OH chain and R2 represents a —CH2—CHF—CHOH—CH2OH chain, or R1 represents a —CHOH—CHOH—CHOH—Rb chain and R2 represents a —CH2—CHOH—CHOH—Rb chain, or R1 represents a —CH2—CHOH—CHOH—CH2OH chain and R2 represents a —CH2—CHOH—CHOH—CH2OH chain, or R1 and R2 are identical and each represent a —(CHOH)n—CH2OH chain in which n is equal to 1, 2, 3 or 4, Ra represents an alkoxy radical (1-6 C in a straight or branched chain) or a fluorine atom, and Rb represents a carboxyl, —CO—NH2 or —CH2—NH2 radical, or one of their stereoisomers or their salts with an inorganic or organic acid, to novel compounds of formula (I) and to their preparation.

    摘要翻译： 本发明涉及包含至少一种下式的化合物的药物：其中R1表示-CH（Ra）-CHOH-CHOH-CH2OH链，R2表示-CH2-CHOH-CHOH-CH2OH链，或R1表示-CHOH- CHF-CHOH-CH2OH链，R2表示-CH2-CHF-CHOH-CH2OH链，或R1表示-CHOH-CHOH-CHOH-Rb链，R2表示-CH2-CHOH-CHOH-Rb链，或R1表示 -CH 2 -CHOH-CHOH-CH 2 OH链，R 2表示-CH 2 -CHOH-CHOH-CH 2 OH链，或R 1和R 2相同，各自表示其中n等于1的 - （CHOH）n -CH 2 OH链， 2,3或4中，Ra表示烷氧基（直链或支链中1-6C）或氟原子，Rb表示羧基，-CO-NH2或-CH2-NH2基，或其立体异构体或 它们与无机或有机酸的盐，与式（I）的新型化合物及其制备。