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    BIOLOGICAL MATERIALS RELATED TO HER3
    7.
    发明申请
    BIOLOGICAL MATERIALS RELATED TO HER3 有权
    与其相关的生物材料3

    公开(公告)号：US20130136748A1

    公开(公告)日：2013-05-30

    申请号：US13698992

    申请日：2011-05-20

    申请人： Christine Knuehl ,  Bjoern Hock ,  Robert Hofmeister ,  Gerald Beste ,  Hilde Adi Pierrette Revets ,  Frank Kamiel Delphina Verdonck ,  Sigrid Godelieve Victor Cornelis

    发明人： Christine Knuehl ,  Bjoern Hock ,  Robert Hofmeister ,  Gerald Beste ,  Hilde Adi Pierrette Revets ,  Frank Kamiel Delphina Verdonck ,  Sigrid Godelieve Victor Cornelis

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

    摘要： The present disclosure relates to amino acid sequences that are directed against (as defined herein) HER3, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). The disclosure also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as “nucleic acids of the invention” or “nucleotide sequences of the invention”); to methods for 10 preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.

    摘要翻译： 本公开涉及针对（如本文所定义）HER3以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列（也称为 在本文中分别为“本发明的氨基酸序列”，“本发明的化合物”和“本发明的多肽”）。 本公开还涉及编码这种氨基酸序列和多肽（本文中也称为“本发明的核酸”或“本发明的核苷酸序列”）的核酸; 涉及10种制备此类氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的，例如本文提及的预防，治疗或诊断目的。

    IMMUNOGLOBULIN CONSTRUCTS
    8.
    发明申请
    IMMUNOGLOBULIN CONSTRUCTS 审中-公开
    免疫球蛋白构建体

    公开(公告)号：US20110189203A1

    公开(公告)日：2011-08-04

    申请号：US12745023

    申请日：2008-11-27

    申请人： Guy Hermans ,  Hilde Adi Pierrette Revets ,  Michael John Scott Saunders

    发明人： Guy Hermans ,  Hilde Adi Pierrette Revets ,  Michael John Scott Saunders

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06 ,  C12N5/16 ,  A61P35/00

    CPC分类号： C07K16/2863 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/3007 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/00

    摘要： The present invention relates to protein and polypeptide constructs that comprise single variable domains that are linked to an Fc portion. The immunoglobulin constructs comprise two polypeptide chains in which each polypeptide chain comprises two or more single variable domains that are linked, usually via a suitable hinge region or linker, to one or more constant domains that, together, form an Fc portion. The invention also relates to polypeptide chains that form part of such constructs and/or that can be used to form such constructs. The invention further relates to nucleotide sequences and nucleic acids that encode or can be used to express such constructs or polypeptide chains; to methods for producing such constructs and polypeptides chains; to compositions (and in particular pharmaceutical compositions) that comprise such constructs or polypeptide chains; and to uses of such constructs, polypeptide chains or compositions.

    摘要翻译： 本发明涉及包含与Fc部分连接的单个可变结构域的蛋白质和多肽构建体。 免疫球蛋白构建体包含两条多肽链，其中每个多肽链包含两个或更多个单可变结构域，其通常通过合适的铰链区或接头连接到一个或多个恒定区，一起形成Fc部分。 本发明还涉及形成这种构建体的一部分的多肽链和/或可用于形成此类构建体的多肽链。 本发明还涉及编码或可用于表达此类构建体或多肽链的核苷酸序列和核酸; 涉及产生这种构建体和多肽链的方法; 包括这样的构建体或多肽链的组合物（特别是药物组合物）; 以及这种构建体，多肽链或组合物的用途。