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公开(公告)号：US20110117113A1
公开(公告)日：2011-05-19
申请号：US12897051
申请日：2010-10-04
申请人： Gerald Beste , Stephanie Staelens , Peter Vanlandschoot , Maria Gonzalez Pajuelo , Hilde Adi Pierrette Revets , Peter Schotte , Hilde Stals , Ann Brige , Maarten Dewilde , Catelijne Stortelers
发明人： Gerald Beste , Stephanie Staelens , Peter Vanlandschoot , Maria Gonzalez Pajuelo , Hilde Adi Pierrette Revets , Peter Schotte , Hilde Stals , Ann Brige , Maarten Dewilde , Catelijne Stortelers
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C07K19/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P29/00 , A61P31/00 , A61P17/06 , A61P11/06 , A61P11/00 , A61P37/06
CPC分类号： C07K16/2866 , C07K16/00 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The invention relates to immunoglobulin single variable domains directed against specific human CXCR4 epitopes (herein also referred to interchangeably as “compounds of the invention”, “amino acid sequences of the invention”, or “building blocks of the invention”) and polypeptides comprising them (herein also referred to as “polypeptides of the invention”, “compounds of the invention”, or “constructs of the invention”).Furthermore, the present invention relates to nucleic acids encoding the compounds of the invention (also referred to herein as “nucleic acids of the invention” or “nucleotide sequences of the invention”); to methods for preparing the compounds of the invention; to host cells expressing or capable of expressing the compounds of the invention; to compositions, and in particular to pharmaceutical compositions, that comprise the compounds of the invention; and to uses of the compounds of the invention and the aforementioned nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.The invention also relates to methods for generating immunoglobulin single variable domains against a target such as a cell-associated protein and constructs comprising said immunoglobulin single variable domains. The invention also provides immunoglobulin single variable domains obtainable by the methods of the invention. Specifically, the present invention relates to the generation of immunoglobulin single variable domains and constructs thereof by use of epitope walking with multimer libraries. More specifically, the present invention relates to the generation of immunoglobulin single variable domains derived from camelids directed against a particular epitope of a target, in particular against a target with multiple transmembrane spanning domains, including GPCRs and ion channels, by epitope walking with multimer libraries.
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公开(公告)号：US20110262438A1
公开(公告)日：2011-10-27
申请号：US13073044
申请日：2011-03-28
申请人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
发明人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
IPC分类号： A61K39/395 , C12N15/13 , C12P21/08 , A61P35/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P11/06 , A61P9/10 , A61P37/06 , C07K16/28 , A61P25/28
CPC分类号： C07K16/2866 , A61K39/39558 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。
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公开(公告)号：US20150158948A9
公开(公告)日：2015-06-11
申请号：US14008011
申请日：2012-03-28
申请人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
发明人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/507 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2319/31
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 特别地，本发明提供了抑制CXCR7介导的肿瘤生长的免疫球蛋白单可变结构域。
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公开(公告)号：US20140227270A1
公开(公告)日：2014-08-14
申请号：US14008011
申请日：2012-03-28
申请人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
发明人： Francis Descamps , David André Baptiste Maussang-Detaille , Maarten Van Roy , Regorius Leurs , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Martine Smit , Catelijne Stortelers , Philippe Van Rompaey , Peter Vanlandschoot
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/507 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/569 , C07K2317/76 , C07K2319/31
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 特别地，本发明提供了抑制CXCR7介导的肿瘤生长的免疫球蛋白单可变结构域。
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公开(公告)号：US08937164B2
公开(公告)日：2015-01-20
申请号：US13073044
申请日：2011-03-28
申请人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
发明人： Francis Descamps , Maria Gonzalez Pajuelo , Pascal Gerard Merchiers , Catelijne Stortelers , Peter Vanlandschoot , Philippe Van Rompaey , Martine Smit , Regorius Leurs , David Andre Baptiste Maussang Detaille
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/39558 , A61K2039/505 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及特定的多肽，编码这种多肽的核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。
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公开(公告)号：US20100173799A1
公开(公告)日：2010-07-08
申请号：US12643286
申请日：2009-12-21
申请人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
发明人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
IPC分类号： C40B30/04
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
摘要翻译： 本发明涉及产生针对细胞相关抗原的免疫球蛋白序列的方法，更具体地说，涉及膜锚定的抗原。 本发明还提供可通过本发明的方法获得的免疫球蛋白序列。 具体地说，本发明涉及使用DNA疫苗接种产生免疫球蛋白序列。 更具体地，本发明涉及通过DNA疫苗接种在骆驼中产生免疫球蛋白序列，优选针对细胞相关抗原，特别是具有多个跨膜跨越结构域的抗原，包括GPCR和离子通道。 此外，本发明涉及针对细胞相关抗原的所述免疫球蛋白序列，更具体地，涉及膜锚定的抗原，例如抗体。 GPCR和离子通道，更优选离子通道。
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公开(公告)号：US09260508B2
公开(公告)日：2016-02-16
申请号：US12643286
申请日：2009-12-21
申请人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
发明人： Toon Laeremans , Catelijne Stortelers , Friedrich Nolte , Maria Gonzalez Pajuelo , Joana Assunção , Philippe Van Rompaey
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
摘要翻译： 本发明涉及产生针对细胞相关抗原的免疫球蛋白序列的方法，更具体地说，涉及膜锚定的抗原。 本发明还提供可通过本发明的方法获得的免疫球蛋白序列。 具体地说，本发明涉及使用DNA疫苗接种产生免疫球蛋白序列。 更具体地，本发明涉及通过DNA疫苗接种在骆驼中产生免疫球蛋白序列，优选针对细胞相关抗原，特别是具有多个跨膜跨越结构域的抗原，包括GPCR和离子通道。 此外，本发明涉及针对细胞相关抗原的所述免疫球蛋白序列，更具体地，涉及膜锚定的抗原，例如抗体。 GPCR和离子通道，更优选离子通道。
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8.发明授权Monovalent, bivalent and trivalent anti human respiratory syncytial virus (HRSV) nanobody constructs for the prevention and/or treatment of respiratory tract infections 有权用于预防和/或治疗呼吸道感染的单价，二价和三价抗人呼吸道合胞体病毒（HRSV）纳米抗体构建体公开(公告)号：US08945567B2
公开(公告)日：2015-02-03
申请号：US13375357
申请日：2010-06-07
CPC分类号： C07K16/1027 , A61K2039/505 , A61M11/00 , A61M15/0065 , A61M2202/064 , C07K2317/22 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.
摘要翻译： 提供了针对和/或可以特异性结合hRSV的蛋白F的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 由本发明提供的氨基酸序列，多肽和治疗化合物和组合物显示hRSV的蛋白F的改善的稳定性，较少的免疫原性和/或改善的亲和力和/或亲合力。 本发明还涉及这种氨基酸序列，多肽，化合物或构建体用于预防和/或治疗目的的用途。
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9.发明申请MONOVALENT, BIVALENT AND TRIVALENT ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) NANOBODY CONSTRUCTS FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS 有权用于预防和/或治疗呼吸道感染的单一，双重和多重抗人类呼吸道综合病毒（HRSV）纳米结构公开(公告)号：US20120128669A1
公开(公告)日：2012-05-24
申请号：US13375357
申请日：2010-06-07
IPC分类号： A61K39/42 , C12N15/13 , C12N15/63 , C12P21/02 , C07K1/107 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , A01H5/00 , A61P31/14 , A61P11/00 , A61P29/00 , A61P11/06 , C07K16/10
CPC分类号： C07K16/1027 , A61K2039/505 , A61M11/00 , A61M15/0065 , A61M2202/064 , C07K2317/22 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.
摘要翻译： 提供了针对和/或可以特异性结合hRSV的蛋白F的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 由本发明提供的氨基酸序列，多肽和治疗化合物和组合物显示hRSV的蛋白F的改善的稳定性，较少的免疫原性和/或改善的亲和力和/或亲合力。 本发明还涉及这种氨基酸序列，多肽，化合物或构建体用于预防和/或治疗目的的用途。
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10.发明授权Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases 有权针对病毒的包膜蛋白的氨基酸序列和包含其的用于治疗病毒性疾病的多肽公开(公告)号：US09193780B2
公开(公告)日：2015-11-24
申请号：US12996074
申请日：2009-06-05
申请人： Anna Hultberg , Bram Maassen , Peter Vanlandschoot , Erik Depla , Catelijne Stortelers , Cornelis Theodorus Verrips , Steven Van Gucht , Jose Melero , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Robert Anthony Weiss , Nigel J. Temperton , Xavier Saelens , Bert Schepens , Alexander Szyroki , Michael Marie Harmsen
发明人： Anna Hultberg , Bram Maassen , Peter Vanlandschoot , Erik Depla , Catelijne Stortelers , Cornelis Theodorus Verrips , Steven Van Gucht , Jose Melero , Michael John Scott Saunders , Johannes Joseph Wilhelmus De Haard , Robert Anthony Weiss , Nigel J. Temperton , Xavier Saelens , Bert Schepens , Alexander Szyroki , Michael Marie Harmsen
IPC分类号： A61K39/395 , C07K2/00 , C07K14/00 , C07K16/00 , C07H21/00 , C12N5/10 , A61K38/16 , C12P21/02 , A61P31/12 , A61P37/02 , C07K16/10 , A61K39/00
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K16/10 , C07K16/1009 , C07K16/1018 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates in part to amino acid sequences that are directed against and/or that can specifically bind to an envelope protein of a virus, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译： 本发明部分地涉及针对和/或可以特异性结合病毒的包膜蛋白的氨基酸序列，以及包含或基本上由以下组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列 一个或多个这样的氨基酸序列。
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