-
公开(公告)号:US20080199477A1
公开(公告)日:2008-08-21
申请号:US12100088
申请日:2008-04-09
申请人: Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人: Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
IPC分类号: A61K39/00
CPC分类号: C07K14/705 , A61K38/00 , C07K2319/00
摘要: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译: 已经在人细胞中鉴定了编码哺乳动物Toll样受体(TLR)的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克,炎性病症和病毒感染。
-
公开(公告)号:US20080194800A1
公开(公告)日:2008-08-14
申请号:US12100108
申请日:2008-04-09
申请人: Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人: Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
CPC分类号: C07K14/705 , A61K38/00 , C07K2319/00
摘要: Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译: 已经在人细胞中鉴定了编码哺乳动物Toll样受体(TLR)的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克,炎性病症和病毒感染。
-