-
公开(公告)号：US20100266599A1
公开(公告)日：2010-10-21
申请号：US12715848
申请日：2010-03-02
申请人： GERARD T. HARDIMAN , FERNANDO L. ROCK , J. FERNANDO BAZAN , ROBERT A. KASTELEIN , STEPHEN W.K. HO , YONG-JUN LIU
发明人： GERARD T. HARDIMAN , FERNANDO L. ROCK , J. FERNANDO BAZAN , ROBERT A. KASTELEIN , STEPHEN W.K. HO , YONG-JUN LIU
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/63 , C07K16/00 , A61P31/00 , A61P31/12 , A61P35/02 , A61P35/00 , A61P37/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
-
2.发明授权Method for blocking binding of CX3C chemokines using CX3C chemokine antibodies 失效使用CX3C趋化因子抗体阻断CX3C趋化因子结合的方法公开(公告)号：US08343492B2
公开(公告)日：2013-01-01
申请号：US13453224
申请日：2012-04-23
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , J. Fernando Bazan , Thomas J. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , J. Fernando Bazan , Thomas J. Schall , Albert Zlotnik
IPC分类号： A61K39/395
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。 还提供了使用所述试剂和相关诊断试剂盒的方法。
-
公开(公告)号：US07785804B2
公开(公告)日：2010-08-31
申请号：US12510586
申请日：2009-07-28
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , J. Fernando Bazan , Thomas J. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , J. Fernando Bazan , Thomas J. Schall , Albert Zlotnik
IPC分类号： G01N33/53 , C07K16/24 , A61K39/395
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。 还提供了使用所述试剂和相关诊断试剂盒的方法。
-
4.发明授权公开(公告)号：US07670603B2
公开(公告)日：2010-03-02
申请号：US12100088
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W. K. Ho , Yong-Jun Liu
IPC分类号： A61K39/395 , C12N15/09 , C12P21/06 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
-
公开(公告)号：US07115379B1
公开(公告)日：2006-10-03
申请号：US10397559
申请日：2003-03-25
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Fernando J. Bazan , Thomas B. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Fernando J. Bazan , Thomas B. Schall , Albert Zlotnik
IPC分类号： G01N33/53 , C07K16/24 , A61K39/395
CPC分类号： G01N33/6863 , Y10S435/81 , Y10S435/975
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。 还提供了使用所述试剂和相关诊断试剂盒的方法。
-
公开(公告)号：US20120225482A1
公开(公告)日：2012-09-06
申请号：US13453224
申请日：2012-04-23
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
IPC分类号： C12N5/02 , C07H21/04 , C07K16/24 , G01N33/566 , C07K14/52
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。 还提供了使用所述试剂和相关诊断试剂盒的方法。
-
公开(公告)号：US20080199477A1
公开(公告)日：2008-08-21
申请号：US12100088
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
IPC分类号： A61K39/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
-
公开(公告)号：US20080194800A1
公开(公告)日：2008-08-14
申请号：US12100108
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
-
公开(公告)号：US08173117B2
公开(公告)日：2012-05-08
申请号：US12833069
申请日：2010-07-09
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。 还提供使用所述试剂和相关诊断试剂盒的方法。
-
公开(公告)号：US20090317398A1
公开(公告)日：2009-12-24
申请号：US12510586
申请日：2009-07-28
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译： 描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。 还提供了使用所述试剂和相关诊断试剂盒的方法。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.018 秒)
