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1.发明授权公开(公告)号：US06458821B1
公开(公告)日：2002-10-01
申请号：US09762046
申请日：2001-02-01
IPC分类号： A61K314184
CPC分类号： C07D403/06 , A61K9/0019 , A61K9/2027 , A61K9/2031 , A61K9/284 , A61K9/2853 , A61K47/32 , A61K47/34 , C08F283/06 , C08F218/04
摘要： Compounds of the formula in which R1, R2 and R3 have the meanings stated in the description, are described. The novel substances are suitable for controlling diseases.
摘要翻译： 描述了R1，R2和R3具有说明书所述含义的化合物。新型物质适用于控制疾病。
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2.发明授权公开(公告)号：US06300354B1
公开(公告)日：2001-10-09
申请号：US09744405
申请日：2001-01-24
IPC分类号： A61K31428
CPC分类号： C07D417/06
摘要： Compounds of the formula I: in which R1, R2, R3 and R4 have the meanings stated in the description, are described. The novel compounds are suitable for controlling diseases.
摘要翻译： 描述了其中R1，R2，R3和R4具有说明书所述含义的式I化合物：新化合物适用于控制疾病。
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公开(公告)号：US06472392B1
公开(公告)日：2002-10-29
申请号：US09446520
申请日：1999-12-28
申请人： Dorothea Starck , Stefan Blank , Hans-Jörg Treiber , Liliane Unger , Barbara Neumann-Schultz , Theophile-Marie Le Bris , Hans-Jürgen Teschendorf , Karsten Wicke
发明人： Dorothea Starck , Stefan Blank , Hans-Jörg Treiber , Liliane Unger , Barbara Neumann-Schultz , Theophile-Marie Le Bris , Hans-Jürgen Teschendorf , Karsten Wicke
IPC分类号： C07D40112
CPC分类号： C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Triazole compounds of the following formula: where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
摘要翻译： 下式的三唑化合物：其中Ar1，A，B和Ar2具有说明书中给出的含义，对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3配体作出反应的疾病。
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公开(公告)号：US06352981B1
公开(公告)日：2002-03-05
申请号：US09696941
申请日：2000-10-27
申请人： Hans-Jörg Treiber , Stefan Blank , Dorothea Starck , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke
发明人： Hans-Jörg Treiber , Stefan Blank , Dorothea Starck , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke
IPC分类号： C07D22500
CPC分类号： C07D403/04 , C07D403/12 , C07D403/14 , C07D417/14
摘要： Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2 (I) where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
摘要翻译： 下式的氮杂 - 和二氮杂环己烷和 - 环辛烷化合物：其中Ar1，A，B和Ar2具有说明书中所述的含义，对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3 配体。
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公开(公告)号：US06444674B1
公开(公告)日：2002-09-03
申请号：US09940937
申请日：2001-08-29
申请人： Beate Hellendahl , Annegret Lansky , Rainer Munschauer , Siegfried Bialojan , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke , Karla Drescher
发明人： Beate Hellendahl , Annegret Lansky , Rainer Munschauer , Siegfried Bialojan , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke , Karla Drescher
IPC分类号： C07D23928
CPC分类号： C07D239/47 , A61K31/506 , C07D239/38 , C07D239/56 , C07D239/60
摘要： The present invention relates to the use of pyrimidine compounds of the following formula: where R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
摘要翻译： 本发明涉及下式所示的嘧啶化合物的用途：其中R1，R2，R3，A，B和Ar具有说明书中所述的含义。 根据本发明的化合物对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3配体作出反应的病症。
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公开(公告)号：US06342604B1
公开(公告)日：2002-01-29
申请号：US08765292
申请日：1997-01-14
申请人： Beate Hellendahl , Annegret Lansky , Rainer Munschauer , Siegfried Bialojan , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke , Karla Drescher
发明人： Beate Hellendahl , Annegret Lansky , Rainer Munschauer , Siegfried Bialojan , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke , Karla Drescher
IPC分类号： C07D23928
CPC分类号： C07D239/47 , A61K31/506 , C07D239/38 , C07D239/56 , C07D239/60
摘要： The present invention relates to the use of pyrimidine compounds of the following formula: wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
摘要翻译： 本发明涉及下式的嘧啶化合物的用途：其中R1，R2，R3，A，B和Ar具有说明书中所示的含义。 根据本发明的化合物对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3配体作出反应的病症。
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公开(公告)号：US06403593B1
公开(公告)日：2002-06-11
申请号：US09481976
申请日：2000-01-13
申请人： Beate Hellendahl , Annegret Lansky , Rainer Munschauer , Siegfried Bialojan , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke , Karla Drescher
发明人： Beate Hellendahl , Annegret Lansky , Rainer Munschauer , Siegfried Bialojan , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke , Karla Drescher
IPC分类号： C07D40312
CPC分类号： C07D403/12 , C07D249/12
摘要： The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
摘要翻译： 本发明涉及下式的三唑化合物：其中R1，R2，A，B和Ar具有说明书中所述的含义。 根据本发明的化合物对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3配体作出反应的病症。
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8.发明授权Substituted aza and diazacycloheptane and cyclooctane compounds and their use 失效取代的氮杂和二氮杂环庚烷和环辛烷化合物及其用途公开(公告)号：US06214822B1
公开(公告)日：2001-04-10
申请号：US09101265
申请日：1998-07-06
申请人： Hans-Jörg Treiber , Stefan Blank , Dorothea Starck , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke
发明人： Hans-Jörg Treiber , Stefan Blank , Dorothea Starck , Liliane Unger , Hans-Jürgen Teschendorf , Karsten Wicke
IPC分类号： A61K315513
CPC分类号： C07D403/04 , C07D403/12 , C07D403/14 , C07D417/14
摘要： Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2 (I) where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
摘要翻译： 下式的氮杂 - 和二氮杂环己烷和 - 环辛烷化合物：其中Ar1，A，B和Ar2具有说明书中所述的含义，对多巴胺D3受体具有高亲和力，因此可用于治疗对多巴胺D3 配体。
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![3-substituted 3,4,5,7-tetrahedropyrrolo[3′,4′:4,5]thieno-[2,3-d]pyrimidine derivatives, their preparation and use](/abs-image/US/2002/03/12/US06355647B1/abs.jpg.150x150.jpg)
9.发明授权3-substituted 3,4,5,7-tetrahedropyrrolo[3′,4′:4,5]thieno-[2,3-d]pyrimidine derivatives, their preparation and use 有权3-取代的3,4,5,7-四
取吡咯并[3'，4'：4,5]噻吩并[2,3-d]嘧啶衍生物，其制备和用途公开(公告)号：US06355647B1
公开(公告)日：2002-03-12
申请号：US09485188
申请日：2000-02-07
申请人： Gerd Steiner , Uta Dullweber , Dorothea Starck , Alfred Bach , Karsten Wicke , Hans-Jürgen Teschendorf , Francisco-Javier Garcia-Ladona , Franz Emling
发明人： Gerd Steiner , Uta Dullweber , Dorothea Starck , Alfred Bach , Karsten Wicke , Hans-Jürgen Teschendorf , Francisco-Javier Garcia-Ladona , Franz Emling
IPC分类号： C07D49514
CPC分类号： C07D495/14
摘要： 3-Substituted 3,4,5,7-tetrahydropyrrolo[3′,4′:4,5]thieno-[2,3-d]pyrimidine derivatives of the formula I in which the substituents have the meanings stated in the description, their preparation and their use as drugs.
摘要翻译： 3-取代的式Iin的3,4,5,7-四氢吡咯并[3'，4'：4,5]噻吩并[2,3-d]嘧啶衍生物，其取代基具有如说明书中所述的含义，它们 准备和用作药物。
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10.发明授权2-substituted 1,2-benzisothiazole derivatives and their use as serotonin antagonists (5-HT1A, 5HT1B and 5-HT1D) 有权2-取代的1,2-苯并异噻唑衍生物及其用作5-羟色胺拮抗剂（5-HT1A，5HT1B和5-HT1D）公开(公告)号：US06346622B1
公开(公告)日：2002-02-12
申请号：US09529828
申请日：2000-04-20
申请人： Wilfried Lubisch , Uta Dullweber , Dorothea Starck , Gerd Steiner , Alfred Bach , Franz Emling , Xavier Garcia-Ladona , Hans-Jürgen Teschendorf , Karsten Wicke
发明人： Wilfried Lubisch , Uta Dullweber , Dorothea Starck , Gerd Steiner , Alfred Bach , Franz Emling , Xavier Garcia-Ladona , Hans-Jürgen Teschendorf , Karsten Wicke
IPC分类号： A61K31425
CPC分类号： C07D275/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： where the substituents have the meanings indicated in the description, their preparation and use as serotonin antagonists.
摘要翻译： 其中取代基具有说明书中所示的含义，其制备和用作血清素拮抗剂。
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