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9 条记录 (耗时 0.017 秒)

    Crystalline pharmaceutical product
    2.
    发明授权
    Crystalline pharmaceutical product 失效
    结晶药品

    公开(公告)号：US06335330B1

    公开(公告)日：2002-01-01

    申请号：US09254305

    申请日：1999-03-03

    申请人： Stephen Torey Ross

    发明人： Stephen Torey Ross

    IPC分类号： A61K315513

    CPC分类号： C07D401/14

    摘要： This invention provides (S)-7-[(4,4′-bipiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid, hydrochloride, processes for its preparation and methods for its use.

    摘要翻译： 本发明提供（S）-7 - [（4,4'-联哌啶-1-基）羰基] -2,3,4,5-四氢-4-甲基-3-氧代-1H-1,4-苯并二氮杂 -2-乙酸盐酸盐，其制备方法及其使用方法

    Triazolo-1,4-diazepine compounds and medicinal composition containing the same
    7.
    发明授权
    Triazolo-1,4-diazepine compounds and medicinal composition containing the same 失效
    三唑并-1,4-二氮杂化合物及含有它们的药物组合物

    公开(公告)号：US06433167B1

    公开(公告)日：2002-08-13

    申请号：US09446736

    申请日：1999-12-23

    申请人： Masakazu Fujita ,  Taketsugu Seki ,  Haruaki Inada ,  Tetsuro Sano

    发明人： Masakazu Fujita ,  Taketsugu Seki ,  Haruaki Inada ,  Tetsuro Sano

    IPC分类号： A61K315513

    CPC分类号： C07D495/22

    摘要： A triazolo-1,4-diazepine compound having the formula (I): wherein A represents CO, CO—B, or B, B represents a C1 to C6 alkylene group or a C2 to C6 alkylene group having an oxygen atom interposed in the middle thereof, X represents N—O or CH, n represents an integer of 2 to 6, R represents a hydroxyl group, a C1 to C6 lower alkyloxy group or a C1 to C6 lower alkylamino group, provided that these groups may be substituted with an N,N-dimethylamino group, an N,N-diethylamino group, a phenyl group, or a heterocyclic group, and R1 represents a hydrogen atom or a C1 to C3 lower alkyl group having both a PAF antagonistic action and a thromboxane synthesis inhibiting action, and a pharmaceutical composition containing the same as an active ingredient.

    摘要翻译： 具有式（I）的三唑并[1,4-diazepine]化合物：其中A表示CO，CO-B或B，B表示C1〜C6亚烷基或碳原子上具有氧原子的C2〜C6亚烷基 中间，X表示NO或CH，n表示2〜6的整数，R表示羟基，C1〜C6低级烷氧基或C1〜C6低级烷基氨基，条件是这些基团可以被N ，N-二甲基氨基，N，N-二乙基氨基，苯基或杂环基，R 1表示氢原子或具有PAF拮抗作用和血栓烷烷合成抑制作用的C1〜C3低级烷基， 以及含有活性成分的药物组合物。

    Bezazepine derivatives as &agr;v integrin receptor antagonists
    8.
    发明授权
    Bezazepine derivatives as &agr;v integrin receptor antagonists 失效
    贝沙西平衍生物作为alphav整合素受体拮抗剂

    公开(公告)号：US06232308B1

    公开(公告)日：2001-05-15

    申请号：US09496525

    申请日：2000-02-02

    申请人： Ben C. Askew

    发明人： Ben C. Askew

    IPC分类号： A61K315513

    CPC分类号： C07D491/04

    摘要： The present invention relates to benzazepine derivatives and their use as &agr;v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;v&bgr;3, &agr;v&bgr;5, and/or &agr;v&bgr;6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.

    摘要翻译： 本发明涉及苯并氮杂衍生物及其作为alphav整联蛋白受体拮抗剂的用途。 更具体地说，本发明的化合物是整联蛋白受体alphavbeta3，alphavbeta5和/或alphavbeta6的拮抗剂，可用于抑制骨吸收，治疗和预防骨质疏松，抑制血管再狭窄，糖尿病性视网膜病变，黄斑变性，血管生成，动脉粥样硬化 ，炎症，伤口愈合，病毒性疾病，肿瘤生长和转移。