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公开(公告)号：US08597652B2
公开(公告)日：2013-12-03
申请号：US12728052
申请日：2010-03-19
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
摘要翻译： 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。
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公开(公告)号：US20100255010A1
公开(公告)日：2010-10-07
申请号：US12728052
申请日：2010-03-19
CPC分类号： A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
摘要翻译： 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。
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公开(公告)号：US20140363438A1
公开(公告)日：2014-12-11
申请号：US14239229
申请日：2012-08-16
申请人： Erica Jackson , Gabriele Schaefer , Yan Wu
发明人： Erica Jackson , Gabriele Schaefer , Yan Wu
CPC分类号： C07K16/22 , A01K2267/0331 , A61K47/6845 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/1135 , C12N15/1136 , C12N2310/14 , C12N2310/531 , C12N2330/50 , C12N2740/16043
摘要： The invention provides anti-neuregulin1 antibodies and methods of using the antibodies in treating diseases or disorders, such as cancer. In a particular embodiment, the anti-neuregulin1 antibodies bind to both neuregulin1α and neuregulin 1β isoforms.
摘要翻译： 本发明提供了抗神经调节蛋白1抗体以及使用该抗体治疗诸如癌症的疾病或病症的方法。 在一个具体实施方案中，抗神经调节蛋白1抗体结合神经调节蛋白1和神经调节蛋白1＆bgr; 同种型
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公开(公告)号：US20060029602A1
公开(公告)日：2006-02-09
申请号：US11173893
申请日：2005-07-01
申请人： Gabriele Schaefer , Mark Sliwkowski
发明人： Gabriele Schaefer , Mark Sliwkowski
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04
CPC分类号： C07K14/71 , A61K38/00 , A61K2039/505 , C07K14/4756 , C07K16/32 , C07K19/00 , Y02A50/466 , Y10S435/971
摘要： A novel member of the heregulin superfamily has been identified which is designated “γ-HRG”. This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. γ-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of γ-HRG nucleic acid for the recombinant production of γ-HRG). γ-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.
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