摘要:
Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.
摘要:
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.
摘要:
A system for malicious code detection includes a front-end processor, multiple scanning computer systems, and a detection management system. During operation, the multiple scanning computer systems scan content for malicious code and generate an alarm when the content contains malicious code. The front-end processor receives a flow of content from an external network and distributes copies of the flow to each of the multiple scanning computer systems in parallel for scanning. The detection management system employs a countermeasure on the flow if at least one of the scanning computer systems generates the alarm.
摘要:
A laundry tote having multiple attachments utilizes a base, a drawer, and a plurality of interlocking snap fit liquid receptacles. Each inward surface of the device has attachment points yielding a modular and customizable laundry tote.
摘要:
An approach for providing managed security services is disclosed. A database, within a server or a pre-existing anomalous event detection system, stores a rule set specifying a security policy for a network associated with a customer. An anomalous detection event module is deployed within a premise of the customer and retrieves rule sets from the database. The anomalous detection event module monitors a sub-network of the network based on the rule sets. The anomalous event detection module is further configured to self-organize by examining components of the network and to monitor for anomalous events according to the examined components, and to self-provision by selectively creating another instance of the anomalous detection event module to monitor another sub-network of the network.
摘要:
A head covering for covering the hair, particularly long or braided hair is provided. The head covering comprises a cap portion for covering the head, a pouch portion for encasing the hair and means to secure the head covering to the head. The head covering may be made of any suitable fabric material and may contain elastic to provide a snug fit.