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    DERIVATIVES OF N-[PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[(AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS
    1.
    发明申请
    DERIVATIVES OF N-[PHENYL(PYRROLIDINE-2-YL)METHYL]BENZAMIDE AND N-[(AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS 失效
    N- [苯基（吡咯烷-2-基）甲基]苯甲酰胺和N - [（AZEPAN-2-YL）苯基甲基]苯甲酰胺的衍生物，其制备方法及其在治疗中的应用

    公开(公告)号：US20070208006A1

    公开(公告)日：2007-09-06

    申请号：US11741803

    申请日：2007-04-30

    申请人： Gihad DARGAZANLI ,  Genevieve ESTENNE-BOUHTOU ,  Florence MEDAISKO ,  Nathalie RAKOTOARISOA

    发明人： Gihad DARGAZANLI ,  Genevieve ESTENNE-BOUHTOU ,  Florence MEDAISKO ,  Nathalie RAKOTOARISOA

    IPC分类号： A61K31/55 ,  A61K31/445 ,  A61K31/40

    CPC分类号： C07D223/04 ,  C07D207/09

    摘要： Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine. Moreover, the compounds of the invention may be used for treating painful muscle contracture in rheumatology and in acute spinal pathology; for treating spastic contractures of medullary or cerebral origin; for the symptomatic treatment of acute and subacute pain of light to moderate intensity; for treating intense and/or chronic pain, neurogenic pain and intractable pain; for treating Parkinson's disease and Parkinson-like symptoms of neurodegenerative origin or induced by neuroleptics; for treating partial primary and secondary generalized epilepsy of simple or complex symptomology, mixed forms and other epileptic syndromes in addition to another antiepileptic treatment, or in monotherapy, for the treatment of sleep apnea, and for neuroprotection.

    摘要翻译： 本文定义的式（I）化合物可用于治疗与痴呆，精神病，特别是精神分裂症（缺陷形式和生产形式）和由精神安定药物诱发的急性或慢性锥体外系症状相关的行为障碍; 用于治疗各种形式的焦虑，恐慌发作，恐惧症和强迫性强迫症; 用于治疗各种形式的抑郁症，包括精神病性抑郁症; 用于治疗酒精滥用或酒精断奶引起的疾病，性行为障碍，进食障碍和用于治疗偏头痛。 此外，本发明的化合物可用于治疗风湿病和急性脊髓病变中的疼痛性肌肉挛缩; 用于治疗髓质或脑源性痉挛性挛缩; 用于轻度至中度强度的急性和亚急性疼痛的对症治疗; 用于治疗强烈和/或慢性疼痛，神经源性疼痛和难治性疼痛; 用于治疗帕金森病和神经变性起源的帕金森样症状或由精神安定药诱导; 用于治疗单纯或复杂症状，混合形式和其他癫痫综合征的部分原发性和继发性全身性癫痫以及另一种抗癫痫治疗或单一疗法，用于治疗睡眠呼吸暂停和神经保护。

    DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS
    4.
    发明申请
    DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS 审中-公开
    二氧化-2-烷基碳酸酯的衍生物，其制备方法及其在治疗中的应用

    公开(公告)号：US20060247290A1

    公开(公告)日：2006-11-02

    申请号：US11426964

    申请日：2006-06-28

    申请人： Ahmed ABOUABDELLAH ,  Michele BAS ,  Gihad DARGAZANLI ,  Christian HOORNAERT ,  Adrien LI ,  Florence MEDAISKO

    发明人： Ahmed ABOUABDELLAH ,  Michele BAS ,  Gihad DARGAZANLI ,  Christian HOORNAERT ,  Adrien LI ,  Florence MEDAISKO

    IPC分类号： A61K31/4184 ,  A61K31/4178 ,  C07D405/02

    CPC分类号： C07D319/06 ,  C07C235/06 ,  C07D405/12

    摘要： A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3) alkyl, (C1-C3) alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3-C6)cycloalkyl-O— or (C3-C6)cycloalkyl(C1-C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a methyl group and R4 represents a hydrogen atom or a (C1-C3)alkyl, (C3-C5) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

    摘要翻译： 对应于通式（I）的化合物：其中R 1表示任选被一个或多个卤素原子或羟基取代的苯基或萘基，氰基，硝基，（C 1） （C 1 -C 3）烷基，（C 1 -C 3 -C 3）烷氧基，三氟甲基，三氟甲氧基，苄氧基，（C 3 H 3） C 1 -C 6环烷基-O-或（C 3 -C 6 -C 6）环烷基（C 1 -C 6） C 1 -C 3烷氧基; R 2表示其中R 3 3表示氢原子的通式为CHR 3 CONHR 4 S的基团，或 甲基和R 4代表氢原子或（C 1 -C 3 -C 3）烷基，（C 3 H 3） （C 1 -C 5）环烷基或（吡啶-4-基）甲基; 或2,2,2-三氟乙基; 或（咪唑-2-基）甲基; 或（苯并咪唑-2-基）甲基; 或任选被一个或多个卤素原子取代的苯基或氰基，硝基，（C 1 -C 3 - ）烷基，（C 1 -C 3）烷基， -C 3 -C 3烷氧基，三氟甲基或三氟甲氧基; n表示1〜3的数; 以碱的形式，与酸的加成盐，水合物或溶剂合物的形式。 还公开并要求保护的是由其衍生的药物组合物及其治疗各种疾病的治疗用途。