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    ADHESION-PREVENTING MATERIAL
    1.
    发明申请
    ADHESION-PREVENTING MATERIAL 审中-公开
    粘合防止材料

    公开(公告)号：US20130040911A1

    公开(公告)日：2013-02-14

    申请号：US13638156

    申请日：2010-12-09

    申请人： Gilbu Soe ,  Motonori Aoshima ,  Toshiki Inoue ,  Kiyotaka Hasegawa

    发明人： Gilbu Soe ,  Motonori Aoshima ,  Toshiki Inoue ,  Kiyotaka Hasegawa

    IPC分类号： A61K31/717 ,  A61P41/00 ,  C08B15/05

    CPC分类号： A61L31/148 ,  A61L31/048 ,  C08B11/12 ,  C08B11/20 ,  C08J5/18 ,  C08J2301/28 ,  C08L1/286 ,  C08L2205/025 ,  C08L2205/16 ,  C08L1/28

    摘要： Provided are a novel carboxymethyl cellulose (CMC) structure and a method for producing the same. The CMC structure of the present invention is useful as a medical material and particularly as an adhesion-preventing material, and has good biocompatibility and bioabsorbability and controllable periods of functioning and dissolving, or has both effects for preventing adhesions and wound healing.The CMC structure of the present invention is substantially composed of carboxymethyl celluloses, comprising an acid carboxymethyl cellulose and an alkaline metal carboxymethyl cellulose in a mixed state. The method of production of the present invention comprises subjecting the alkaline metal (or acid) carboxymethyl cellulose structure to an acid (or alkali) treatment, wherein the acid (or alkali) treatment is terminated before the alkaline metal (or acid) carboxymethyl cellulose is fully converted to the acid (or alkaline metal) carboxymethyl cellulose.

    摘要翻译： 提供了一种新型羧甲基纤维素（CMC）结构及其制备方法。 本发明的CMC结构作为医疗用材料，特别是作为防粘连材料是有用的，具有良好的生物相容性和生物吸收性，可控制的功能和溶解时间，或具有防止粘连和伤口愈合的两种效果。 本发明的CMC结构基本上由羧甲基纤维素组成，其包含酸性羧甲基纤维素和混合状态的碱金属羧甲基纤维素。 本发明的生产方法包括使碱金属（或酸）羧甲基纤维素结构经受酸（或碱）处理，其中酸（或碱）处理在碱金属（或酸）羧甲基纤维素是 完全转化为酸（或碱金属）羧甲基纤维素。

    Tissue sealant containing fibrinogen, thrombin and carboxymethyl cellulose or salt thereof
    2.
    发明授权
    Tissue sealant containing fibrinogen, thrombin and carboxymethyl cellulose or salt thereof 有权
    含有纤维蛋白原，凝血酶和羧甲基纤维素的组织密封剂或其盐

    公开(公告)号：US06200587B1

    公开(公告)日：2001-03-13

    申请号：US09312415

    申请日：1999-05-14

    申请人： Gilbu Soe ,  Motonori Aoshima ,  Koichi Takada

    发明人： Gilbu Soe ,  Motonori Aoshima ,  Koichi Takada

    IPC分类号： A61F200

    CPC分类号： A61L24/106 ,  A61L24/043 ,  C08L89/06

    摘要： A tissue sealant comprising thrombin, fibrinogen, and carboxylmethyl cellulose or an alkali metal or alkali earth metal salt thereof is disclosed. The tissue sealant of the present invention promotes a hemostasis of an injury to a skin surface or a viscus, a healing of an injury, an endothelium formation of a blood vessel, an adhesive activity of animal cells, such as endothelial cells or fibroblasts in vitro, and an adhesion and agglutination of platelets.

    摘要翻译： 公开了包含凝血酶，纤维蛋白原和羧甲基纤维素或其碱金属或碱土金属盐的组织密封剂。 本发明的组织密封剂促进对皮肤表面或粘液的损伤止血，损伤的愈合，血管的内皮形成，体外的动物细胞如内皮细胞或成纤维细胞的粘附活性 ，以及血小板的粘附和凝集。

    Hemostatic agent
    5.
    发明授权
    Hemostatic agent 有权
    止血剂

    公开(公告)号：US06214808B1

    公开(公告)日：2001-04-10

    申请号：US09312416

    申请日：1999-05-14

    申请人： Gilbu Soe ,  Motonori Aoshima ,  Koichi Takada

    发明人： Gilbu Soe ,  Motonori Aoshima ,  Koichi Takada

    IPC分类号： A61K31715

    CPC分类号： A61K31/717 ,  A61L15/28 ,  A61L2400/04 ,  C08L1/26

    摘要： A hemostatic agent, an age for promoting cellular adhesion and an agent for curing an injury, each comprising an alkali or alkali earth metal salt of carboxylmethyl cellulose, and a pharmaceutically acceptable carrier are disclosed.

    摘要翻译： 公开了一种止血剂，促进细胞粘附的时代和用于治疗损伤的药剂，其各自包含羧甲基纤维素的碱金属或碱土金属盐和药学上可接受的载体。

    Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same
    6.
    发明授权
    Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same 失效
    含有用于治疗伤口的凝血蛋白的止血可溶性纤维素纤维及其制备方法

    公开(公告)号：US07351422B2

    公开(公告)日：2008-04-01

    申请号：US10069561

    申请日：2001-02-22

    申请人： Yoshio Jo ,  Motonori Aoshima ,  Koji Tanabe ,  Koichi Matsushita ,  Toshiki Inoue

    发明人： Yoshio Jo ,  Motonori Aoshima ,  Koji Tanabe ,  Koichi Matsushita ,  Toshiki Inoue

    IPC分类号： A61F2/00 ,  A61K9/00 ,  A61K9/70 ,  A61K35/12 ,  C08B11/00

    CPC分类号： D06M23/06 ,  A61K31/717 ,  A61L15/225 ,  A61L15/28 ,  A61L15/32 ,  A61L2400/04 ,  D06M11/38 ,  D06M13/21 ,  D06M15/15 ,  C08L1/26 ,  C08L89/00 ,  C08L1/00

    摘要： Proposed is a novel soluble trauma-healing and hemostatic cellulose fiber capable of absorbing and readily dissolving hemorrhaging trauma loci when applied thereto and of promoting the hemostatic action of blood platelets and fibrin and cell adhesion to the trauma site. The coagulation protein-containing soluble trauma-healing and hemostatic cellulose fiber is produced in that after treatment of a natural or regenerated cellulose fiber with an aqueous sodium hydroxide solution, said fiber is carboxymethylated by reaction with a monochloro acetic acid solution for a given time (hours) in such a manner that the degree of partial substitution of the glucose units constituting the cellulose molecule (etherification degree) is 0.5-less than 1.0% and that, furthermore, the coagulation proteins fibrinogen, thrombin, and coagulation factor XIII are imparted by surface application or chemical bonding.

    摘要翻译： 提出了一种新颖的可溶性创伤愈合和止血纤维素纤维，其能够吸收并容易地溶解出血创伤基因座，并且促进血小板和纤维蛋白的止血作用以及细胞粘附于创伤部位。 产生含凝固蛋白质的可溶性创伤愈合和止血纤维素纤维，其中在用氢氧化钠水溶液处理天然或再生纤维素纤维后，所述纤维通过与一氯乙酸溶液反应给定时间而羧甲基化（给定时间 小时），构成纤维素分子的葡萄糖单元的部分取代度（醚化度）为0.5％以下，并且凝固蛋白质纤维蛋白原，凝血酶和凝血因子XIII由 表面应用或化学键合。