公开(公告)号：US12258346B2

公开(公告)日：2025-03-25

申请号：US18543272

申请日：2023-12-18

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Mark J. Bartlett ,  Jayaraman Chandrasekhar ,  Julian A Codelli ,  John H. Conway ,  Jennifer L Cosman Ellis ,  Rao V. Kalla ,  Zachary A Kasun ,  Musong Kim ,  Seung H. Lee ,  Jennifer R. Lo ,  Jennifer A. Loyer-Drew ,  Scott A. Mitchell ,  Thao D. Perry ,  Gary B. Phillips ,  Patrick J. Salvo ,  Sundaramoorthi Swaminathan ,  Joshua J. Van Veldhuizen ,  Suet C. Yeung ,  Jeff Zablocki

IPC: C07D471/04 ,  A61K31/437 ,  C07D519/00

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.