公开(公告)号：US20210171543A1

公开(公告)日：2021-06-10

申请号：US17094447

申请日：2020-11-10

申请人： Gilead Sciences, Inc.

发明人： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC分类号： C07D513/18 ,  C07D519/00 ,  C07D513/20 ,  C07D513/08 ,  C07D513/22 ,  A61K45/06 ,  C07K16/28

摘要： The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US11976072B2

公开(公告)日：2024-05-07

申请号：US17845534

申请日：2022-06-21

申请人： Gilead Sciences, Inc.

发明人： Julian A. Codelli ,  Michael Graupe ,  Juan A. Guerrero ,  Stephen D. Holmbo ,  Tetsuya Kobayashi ,  Yasamin Moazami ,  Leena B. Patel ,  Heath A. Weaver ,  Jie Xu ,  Suet C. Yeung ,  QingMing Zhu

IPC分类号： C07D487/04 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US11667652B2

公开(公告)日：2023-06-06

申请号：US17094447

申请日：2020-11-10

申请人： Gilead Sciences, Inc.

发明人： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC分类号： C07D513/08 ,  C07D513/10 ,  C07D513/20 ,  C07D513/22 ,  A61K31/553 ,  A61P35/00 ,  C07D513/18 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC分类号： C07D513/18 ,  A61K45/06 ,  C07D513/08 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

摘要： The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20230060354A1

公开(公告)日：2023-03-02

申请号：US17845534

申请日：2022-06-21

申请人： Gilead Sciences, Inc.

发明人： Julian A. Codelli ,  Michael Graupe ,  Juan A. Guerrero ,  Stephen D. Holmbo ,  Tetsuya Kobayashi ,  Yasamin Moazami ,  Leena B. Patel ,  Heath A. Weaver ,  Jie Xu ,  Suet C. Yeung ,  QingMing Zhu

IPC分类号： C07D487/04 ,  C07D519/00

摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.