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    Immunogenic glycopeptides, screening, preparation and uses
    10.
    发明授权
    Immunogenic glycopeptides, screening, preparation and uses 失效
    免疫原性糖肽，筛选，制备和用途

    公开(公告)号：US07658929B2

    公开(公告)日：2010-02-09

    申请号：US12034926

    申请日：2008-02-21

    申请人： Gilles Marchal ,  Felix Romain ,  Pascale Pescher

    发明人： Gilles Marchal ,  Felix Romain ,  Pascale Pescher

    IPC分类号： A61K39/00 ,  A61K39/04

    CPC分类号： C07K9/00 ,  A61K39/00 ,  C07K14/35

    摘要： The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or fungi), and methods for selecting them and preparing them. Said glycopeptides are selected in the group consisting of: a1) glycopeptides essentially consisting of a glycosylated T epitope, comprising 14 to 25 amino acids, among which at least a neutral amino acid is bound to a di- or to a trisaccharide (glycoside linkage) and at least 15% among said amino acids are proline, one of the proline being located in position −1 to −4, relative to the position of said neutral amino acid, which glycopeptides are: exhibited by a class II MHC molecule, specifically identified by T CD+4 lymphocytes induced by immunization with the native glycopeptide from which they are derived, but are not identified by the T CD+4 lymphocytes induced by immunization with a non-glycosylated peptide of same sequence and capable of inducing a proliferation of said T CD+4 lymphocytes by which they are identified and the secretion of cytokines by said lymphocytes and b1) glycopeptides having a sequence of 15 to 39 amino acids including the sequence of the glycopeptide as defined in a1), excluding the glycopeptide of sequence SEQ ID NO:11.

    摘要翻译： 本发明涉及来自病原微生物的免疫原性糖肽，其可用于接种和诊断由所述病原微生物（细菌或真菌）引起的感染，以及用于选择和制备它们的方法。 所述糖肽选自：主要由糖基化T表位组成的糖肽，其包含14至25个氨基酸，其中至少一个中性氨基酸与二糖苷或三糖（糖苷键）结合， 并且所述氨基酸中至少15％是脯氨酸，相对于所述中性氨基酸的位置，脯氨酸中的一个位于-1至-4位，该糖肽是由II类MHC分子表现出来的，特异性鉴定的 通过用它们来自其的天然糖肽进行免疫诱导的T CD + 4淋巴细胞，但不能被相同序列的非糖基化肽免疫诱导的T CD + 4淋巴细胞识别，并能够诱导所述 T CD + 4淋巴细胞，以及所述淋巴细胞分泌的细胞因子，b1）具有15至39个氨基酸序列的糖肽，包括糖肽的序列作为defi 在a1）中，不包括序列SEQ ID NO：11的糖肽。