公开(公告)号：US20090192184A1

公开(公告)日：2009-07-30

申请号：US12327139

申请日：2008-12-03

申请人： Giovanni Pozzi ,  Paolo Ghetti ,  Gaetano Balsamo ,  Ettore Negri ,  Andrea Mazzoni ,  Marco Alpegiani ,  Angelo Bedeschi ,  Roberta Pizzocaro

发明人： Giovanni Pozzi ,  Paolo Ghetti ,  Gaetano Balsamo ,  Ettore Negri ,  Andrea Mazzoni ,  Marco Alpegiani ,  Angelo Bedeschi ,  Roberta Pizzocaro

IPC分类号： A61K31/4745 ,  C07D491/22

CPC分类号： C07D491/22

摘要： The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia) Herein referred to as forms α and β, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form α can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form β can be prepared starting from form α.

摘要翻译： 本发明涉及盐酸托泊替康（Ia）的两种新型结晶形式。本文称为α和β型，其特征在于高纯度，并且其制备从工业观点来看是有利的。 事实上，从10-羟基喜树碱开始，方法实际上可以方便地制备，而形式β可以从α形式开始制备。

公开(公告)号：US20050272934A1

公开(公告)日：2005-12-08

申请号：US11140256

申请日：2005-05-31

申请人： Marco Alpegiani ,  Andrea Mazzoni ,  Domenico Vergani ,  Walter Cabri

发明人： Marco Alpegiani ,  Andrea Mazzoni ,  Domenico Vergani ,  Walter Cabri

IPC分类号： C07D401/04 ,  C07D43/04

CPC分类号： C07D401/04

摘要： The invention relates to a process for the preparation of thalidomide (I) comprising the reaction between glutamine (II) and a phthaloylating agent, preferably phthalic anhydride, to give N-phthaloyl-glutamine, which is directly transformed in thalidomide.

摘要翻译： 本发明涉及一种制备沙利度胺（I）的方法，其包括谷氨酰胺（II）和邻苯二甲酰化剂（优选邻苯二甲酸酐）之间的反应，得到直接转化为沙利度胺的N-邻苯二甲酰基谷氨酰胺。

公开(公告)号：US06745676B2

公开(公告)日：2004-06-08

申请号：US10338736

申请日：2003-01-09

申请人： Andrea Mazzoni ,  Marco Mazzanti

发明人： Andrea Mazzoni ,  Marco Mazzanti

IPC分类号： B65B1302

CPC分类号： B65B27/06

摘要： A method for packaging skeins shaped as a circular ring of a flexible element of elongated shape, in particular a cable or a hose, wherein the turns are held unitarily to each other, comprises the following phases: sustaining the skein in overhang towards a binding station holding it by the clamping of opposite planar aces of the skein effected in correspondence with at least a first portion of the skein; binding the skein in correspondence with at least its second, free, portion which projects from the first held portion; rotating the skein around its own axis of symmetry by a predetermined angle with respect to the position of the skein in the previous binding phase; and binding the skein again in correspondence with its own rotated position.

摘要翻译： 包装形状为细长形状的柔性元件（特别是电缆或软管）的圆形环的绞线的方法，其中匝彼此整体地保持，包括以下阶段：将绞纱保持在朝向捆扎台的突出端 通过夹紧与所述绞线的至少第一部分相对应的所述绞丝的相对平面的夹持来保持; 与至少其从第一保持部分突出的第二自由部分相对应地结合绞丝; 围绕其自身的对称轴相对于先前结合阶段中的绞丝的位置旋转预定角度的绞丝; 并且与其自身的旋转位置对应地再次捆扎绞合线。

公开(公告)号：US06546852B1

公开(公告)日：2003-04-15

申请号：US09615750

申请日：2000-07-13

申请人： Andrea Mazzoni ,  Marco Mazzanti

发明人： Andrea Mazzoni ,  Marco Mazzanti

IPC分类号： B65B1302

CPC分类号： B65B27/06

摘要： A method for packaging skeins shaped as a circular ring of a flexible element of elongated shape, in particular a cable or a hose, wherein the turns are held unitarily to each other, comprises the following phases: sustaining the skein in overhang towards a binding station holding it by the clamping of opposite planar faces of the skein effected in correspondence with at least a first portion of the skein; binding the skein in correspondence with at least its second, free, portion which projects from the first held portion; rotating the skein around its own axis of symmetry by a predetermined angle with respect to the position of the skein in the previous binding phase; and binding the skein again in correspondence with its own rotated position. The invention further relates to a machine that realizes the method.

摘要翻译： 包装形状为细长形状的柔性元件（特别是电缆或软管）的圆形环的绞线的方法，其中匝彼此一体地保持，包括以下阶段：将绞纱保持在朝向捆扎台 通过夹紧与绞丝的至少第一部分相对应的绞丝的相对的平面来保持它; 与至少其从第一保持部分突出的第二自由部分相对应地结合绞丝; 围绕其自身的对称轴相对于先前结合阶段中的绞丝的位置旋转预定角度的绞丝; 并且与其自身的旋转位置对应地再次捆扎绞合线。 本发明还涉及实现该方法的机器。