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1.发明申请Crystalline Polymorphs of Topotecan Hydrochloride and Methods for the Preparation Thereof 审中-公开盐酸托泊替康的晶体多晶型物及其制备方法公开(公告)号：US20090192184A1
公开(公告)日：2009-07-30
申请号：US12327139
申请日：2008-12-03
申请人： Giovanni Pozzi , Paolo Ghetti , Gaetano Balsamo , Ettore Negri , Andrea Mazzoni , Marco Alpegiani , Angelo Bedeschi , Roberta Pizzocaro
发明人： Giovanni Pozzi , Paolo Ghetti , Gaetano Balsamo , Ettore Negri , Andrea Mazzoni , Marco Alpegiani , Angelo Bedeschi , Roberta Pizzocaro
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia) Herein referred to as forms α and β, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form α can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form β can be prepared starting from form α.
摘要翻译： 本发明涉及盐酸托泊替康（Ia）的两种新型结晶形式。本文称为α和β型，其特征在于高纯度，并且其制备从工业观点来看是有利的。 事实上，从10-羟基喜树碱开始，方法实际上可以方便地制备，而形式β可以从α形式开始制备。
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公开(公告)号：US20100179180A1
公开(公告)日：2010-07-15
申请号：US12615334
申请日：2009-11-10
申请人： Giovanni POZZI , Paolo Ghetti , Gaetano Balsamo , Ettore Negri , Marco Alpegiani , Angelo Bedeschi , Roberta Pizzocaro
发明人： Giovanni POZZI , Paolo Ghetti , Gaetano Balsamo , Ettore Negri , Marco Alpegiani , Angelo Bedeschi , Roberta Pizzocaro
IPC分类号： A61K31/4375 , C07D491/22 , A61P43/00
CPC分类号： C07D491/22
摘要： Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
摘要翻译： 公开了伊立替康盐酸盐（I）的结晶形式及其制备方法，由伊立替酸盐酸盐或伊立替康的其它多晶型物制备。 所述结晶形式特别适用于工业应用，因为其易于过滤并且具有高稳定性和纯度的特征。
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公开(公告)号：US08247426B2
公开(公告)日：2012-08-21
申请号：US12615334
申请日：2009-11-10
申请人： Giovanni Pozzi , Paolo Ghetti , Gaetano Balsamo , Ettore Negri , Marco Alpegiani , Angelo Bedeschi , Roberta Pizzocaro
发明人： Giovanni Pozzi , Paolo Ghetti , Gaetano Balsamo , Ettore Negri , Marco Alpegiani , Angelo Bedeschi , Roberta Pizzocaro
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
摘要翻译： 公开了伊立替康盐酸盐（I）的结晶形式及其制备方法，由伊立替酸盐酸盐或伊立替康的其它多晶型物制备。 所述结晶形式特别适用于工业应用，因为其易于过滤并且具有高稳定性和纯度的特征。
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4.发明申请Crystalline Form Of Cefdinir Ammonium Salt As An Intermediate For The Preparation Of Pure Cefdinir 审中-公开头孢地尼铵盐作为纯头孢地尼的制备中间体的结晶形式公开(公告)号：US20080033169A1
公开(公告)日：2008-02-07
申请号：US11719599
申请日：2005-10-24
申请人： Giovanni Pozzi , Paolo Ghetti , Gaetano Balsamo , Marco Alpegiani , Walter Cabri
发明人： Giovanni Pozzi , Paolo Ghetti , Gaetano Balsamo , Marco Alpegiani , Walter Cabri
IPC分类号： C07D279/04
CPC分类号： C07D501/00
摘要： The invention relates to crystalline Cefdinir ammonium salt of formula (I) and to a process for the preparation thereof. This salt is particularly advantageous in that it allows to prepare highly pure Cefdinir.
摘要翻译： 本发明涉及式（I）的结晶头孢地尼铵盐及其制备方法。 这种盐是特别有利的，因为它允许制备高纯度的头孢地尼。
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公开(公告)号：US20090275766A1
公开(公告)日：2009-11-05
申请号：US12435094
申请日：2009-05-04
IPC分类号： C07C237/26
CPC分类号： C07C231/24 , C07C2603/46 , C07C237/26
摘要： The invention relates to processes for the preparation of tigecycline (I): a wide spectrum antibiotic belonging to the tetracycline family, in stable amorphous form, by freeze-drying, antisolvent precipitation and nebulization.
摘要翻译： 本发明涉及替加环素（I）的制备方法：属于四环素家族的广谱抗生素，具有稳定的无定形形式，通过冷冻干燥，抗溶剂沉淀和雾化。
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公开(公告)号：US20100311784A1
公开(公告)日：2010-12-09
申请号：US12857776
申请日：2010-08-17
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： A61K31/4375 , C07D491/22 , A61P35/00
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
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公开(公告)号：US20090239893A1
公开(公告)日：2009-09-24
申请号：US11721282
申请日：2005-12-16
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： A61K31/4375 , C07D491/22 , A61P35/00
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
摘要翻译： 本文公开了制备7 - [（E） - 叔丁氧基亚氨基甲基] - 喜树碱（也称为gimatecan）的立体选择性方法。 随着在合适的不同溶剂混合物中进一步溶解和沉淀步骤的添加，也可以通过使用相同的立体选择性方法获得四种新的结晶形式的gimatecan。
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公开(公告)号：US4577016A
公开(公告)日：1986-03-18
申请号：US481924
申请日：1983-04-04
IPC分类号： C07D499/897 , A61K31/43 , A61K31/431 , A61P31/04 , C07D499/04 , C07D499/06 , C07D499/88 , C07D499/883 , C07D519/00 , C07F7/18 , C07D499/00 , A61K31/425
CPC分类号： C07F7/186 , C07D499/88 , C07F7/1804 , Y02P20/55
摘要： A process for the preparation of compounds of formula (I) ##STR1## wherein R.sub.1 is hydrogen or an organic group;R.sub.2 is hydrogen or a carboxy protecting group; andY is a group-S-heterocyclic, acyloxy, alkoxy, alkylthio, pyridyl, which group may be substituted, or azido, and penem derivatives falling within the scope of formula (I) and pharmaceutically or veterinarily acceptable salts thereof.The process involves displacing a group L in the Y position with a reagent Y-H.
摘要翻译： 制备式（I）化合物的方法其中R 1是氢或有机基团; R2是氢或羧基保护基; Y是可以被取代的基团-S-杂环，酰氧基，烷氧基，烷硫基，吡啶基，或叠氮基和落在式（I）的范围内的青霉烯衍生物及其药学上或兽医学上可接受的盐。 该方法包括用试剂Y-H置换Y位置的基团L.
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公开(公告)号：US08124769B2
公开(公告)日：2012-02-28
申请号：US12857743
申请日：2010-08-17
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： C07D471/00 , A01N43/42
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
摘要翻译： 本文公开了制备7 - [（E） - 叔丁氧基亚氨基甲基] - 喜树碱（也称为gimatecan）的立体选择性方法。 随着在合适的不同溶剂混合物中进一步溶解和沉淀步骤的添加，也可以通过使用相同的立体选择性方法获得四种新的结晶形式的gimatecan。
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公开(公告)号：US08101758B2
公开(公告)日：2012-01-24
申请号：US12857776
申请日：2010-08-17
申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
发明人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
IPC分类号： C07D471/00 , A01N43/42
CPC分类号： C07D491/22
摘要： A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
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