公开(公告)号：US5449520A

公开(公告)日：1995-09-12

申请号：US130624

申请日：1993-10-01

申请人： Giuliano Frigerio ,  Enzo Giorgetti ,  Emilia Chiodini

发明人： Giuliano Frigerio ,  Enzo Giorgetti ,  Emilia Chiodini

IPC分类号： A61K9/00 ,  A61K9/12 ,  A61K31/23 ,  A61K31/235 ,  A61K31/555 ,  A61K31/57 ,  A61K31/60 ,  A61K36/00 ,  A61K36/53 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P29/00 ,  A61P31/04 ,  A61F9/02

CPC分类号： A61K9/0031 ,  A61K9/122

摘要： The invention provides a pharmaceutical composition for the rectal administration of active principles which exhibit a prevalently topical medication action at the colon level, characterized in that said active principles are formulated in a fluid vehicle able to generate a foam on rectal administration.

摘要翻译： 本发明提供了一种用于直肠施用活性成分的药物组合物，其在结肠水平上表现出普遍的局部用药作用，其特征在于所述活性成分被配制成能够在直肠给药时产生泡沫的流体载体。

公开(公告)号：US5124144A

公开(公告)日：1992-06-23

申请号：US508251

申请日：1990-04-11

申请人： Enzo Giorgetti ,  Virginio Castagnola, deceased ,  Giuliano Frigerio

发明人： Enzo Giorgetti ,  Virginio Castagnola, deceased ,  Giuliano Frigerio

IPC分类号： A61K31/395 ,  A61K31/765 ,  A61K33/14 ,  A61K47/04 ,  A61K47/22 ,  A61K47/44 ,  A61P1/10

CPC分类号： A61K31/765 ,  A61K33/14 ,  Y10S514/867 ,  Y10S514/892 ,  Y10S514/921 ,  Y10S514/974

摘要： The invention provides an orally administered pharmaceutical composition for use in gastrointestinal washes, particularly for diagnostic use, or as a cathartic laxative, of the type containing polyethyleneglycol, anhydrous sodium sulphate, sodium bicarbonate, sodium chloride and potassium chloride, characterized by also containing the following components: saccharin, acesulfame-K and a flavoring chosen from the following: mandarin, fresh fruit flavoring.

公开(公告)号：US5900252A

公开(公告)日：1999-05-04

申请号：US972660

申请日：1992-11-06

申请人： Massimo Calanchi ,  Marco Zema ,  Gabriele Brunetti ,  Enzo Giorgetti

发明人： Massimo Calanchi ,  Marco Zema ,  Gabriele Brunetti ,  Enzo Giorgetti

IPC分类号： A61K9/24 ,  A61K9/30 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K31/575 ,  A61K31/60 ,  A61K31/606 ,  A61K36/53 ,  A61K45/08 ,  A61K47/32 ,  A61K47/38 ,  A61K9/16

CPC分类号： A61K9/5073

摘要： The object of the present invention is to obtain a targeted and controlled release of drugs, the pharmacological action and absorption of which takes place in the intestine and in particular in the ileum and in the colon.To achieve this objective the drug is coated with two membranes, one having pH dependent solubility and the other insoluble but permeable to intestinal juices.As long as the coated drug remains in the stomach and in the upper part of the intestinal tract, that is as long as the pH is lower than 5.5, it is not released.Only when it reaches an environment with a higher pH (small intestine and/or colon), the pH dependent membrane dissolves and the release of the drug can begin.From this moment the second membrane, pH-independent but permeable to intestinal juices, carries out its action which is to slow down and control the dissolution of the drug in the small intestine-colon tract.

摘要翻译： 本发明的目的是获得药物的靶向和控制释放，其药理作用和吸收发生在肠内，特别是在回肠和结肠中。 为了达到这个目标，药物涂上两个膜，一个具有pH依赖性的溶解度，另一个是不可溶的但是可以渗透肠液。 只要涂覆的药物保留在胃中和肠道上部，即只要pH低于5.5，就不会释放。 只有当pH达到pH值较小（小肠和/或结肠）的环境时，pH依赖性膜溶解才能开始释放药物。 从这一刻起，第二个膜，不依赖于pH，但对肠液可渗透，其作用是减缓和控制药物在小肠结肠中的溶解。