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    Enzymatic depolymerisation of carboxymethylcellulose in hydroalcoholic solutions
    1.
    发明申请
    Enzymatic depolymerisation of carboxymethylcellulose in hydroalcoholic solutions 审中-公开
    羧甲基纤维素在水醇溶液中的酶解解

    公开(公告)号：US20060281154A1

    公开(公告)日：2006-12-14

    申请号：US10564741

    申请日：2004-07-14

    申请人： Giuseppe Molteni ,  Cristina Formantici ,  Cristina Demarchi ,  Yves Galante ,  Giuseppe Libassi

    发明人： Giuseppe Molteni ,  Cristina Formantici ,  Cristina Demarchi ,  Yves Galante ,  Giuseppe Libassi

    IPC分类号： C12P19/04 ,  A61K31/716

    CPC分类号： C08B11/20 ,  C12P19/14

    摘要： The present invention refers to the procedure for the preparation of aqueous concentrated solutions of low viscosity carboxymethylcellulose by enzymatic depolymerisation of medium viscosity carboxymethylcellulose in the form of dispersed powder in a hydro-alcoholic heterogeneous medium, and to such aqueous concentrated solutions which have Brookfield viscosity, at 20° C. and 20 rpm, comprised between 2000 and 5000 mPa*s. Preferred alcohol-water biphasic systems have from 40% to 50% of alcohol (e.g., ethanol or isopropanol). The aqueous solutions of carboxymethylcellulose produced are stable over time, and their viscosity varies no more than 10% in 3 months.

    摘要翻译： 本发明涉及通过在分散粉末形式的中等粘度的羧甲基纤维素在含水异构介质中的酶促解聚制备低粘度羧甲基纤维素水溶液的方法，以及具有布鲁克菲尔德粘度的这种水性浓缩溶液， 在20℃和20rpm下，包括在2000和5000mPa * s之间。 优选的醇 - 水双相系统具有40％至50％的醇（例如乙醇或异丙醇）。 生产的羧甲基纤维素水溶液随时间稳定，3个月内粘度变化不超过10％。

    7-.alpha.Hydrazinoacetamido derivatives of cephalosporanic
    2.
    发明授权
    7-.alpha.Hydrazinoacetamido derivatives of cephalosporanic 失效
    7- {60头孢菌素的肼基-N-乙酰氨基衍生物

    公开(公告)号：US3998950A

    公开(公告)日：1976-12-21

    申请号：US563135

    申请日：1975-03-28

    申请人： Renato Broggi ,  Giuseppe Libassi ,  Giorgio Pifferi

    发明人： Renato Broggi ,  Giuseppe Libassi ,  Giorgio Pifferi

    IPC分类号： A61K20060101 ,  A61K31/545 ,  C07D20060101 ,  C07D205/08 ,  C07D213/04 ,  C07D279/06 ,  C07D333/04 ,  C07D501/06 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/32 ,  C07D501/34 ,  C07D501/38 ,  C07D501/42 ,  C07D501/60

    CPC分类号： C07D501/20 ,  Y02P20/55

    摘要： Derivatives of 7-aminocephalosporanic acid of the formula: ##STR1## wherein the carbon atom marked with an asterisk represents an asymmetry center of the molecule, A represents an aromatic nucleus, preferably phenyl which may be substituted by alkyl having 1-4 carbon atoms, halogen, hydroxy or alkoxy having 1-4 carbon atoms, or a heterocyclic nucleus, preferably 2- or 3-thiophene which may be, for example, substituted by halogen, R represents a hydrogen atom or a straight or branched chain lower alkyl radical, R.sub.1 represents a hydrogen atom, a hydroxy group, an acetoxy or pyridinium group. The invention includes the compounds as such or in the form of separated epimers as well as the corresponding pharmaceutically acceptable salts with alkali or alkaline-earth metals, with suitable organic bases or corresponding suitable organic or inorganic acid addition salts. Also method of preparing same. The compounds have powerful antibacterial action against gram-positive and gram-negative bacteria.

    摘要翻译： 7-氨基头孢烷酸的衍生物，具有下式：其中标有星号的碳原子代表分子的不对称中心，A代表芳香核，优选苯基，其可被具有1-4个碳原子的烷基取代 碳原子，卤素，羟基或具有1-4个碳原子的烷氧基，或杂环核，优选可以被卤素取代的2-或3-噻吩，R表示氢原子或直链或支链低级 烷基，R 1表示氢原子，羟基，乙酰氧基或吡啶鎓基。 本发明包括这样的化合物或分离的差向异构体的形式，以及与碱金属或碱土金属的相应的药学上可接受的盐，以及合适的有机碱或相应​​的合适的有机或无机酸加成盐。 还有制备方法。 这些化合物对革兰氏阳性和革兰氏阴性细菌具有强大的抗菌作用。