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公开(公告)号：US20170368034A1
公开(公告)日：2017-12-28
申请号：US15537637
申请日：2015-12-21
IPC: A61K31/4196 , A61K31/095 , A61K31/404 , A61K31/44 , C07D401/14 , G01N23/20
CPC classification number: A61K31/4196 , A61K31/095 , A61K31/404 , A61K31/44 , C07D401/14 , G01N23/20075 , Y02A50/411
Abstract: The present invention relates to a compound of Formula (I) or tautomers thereof having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (R)-2-((3-(3,5-dichloropyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)-1-(1H-indol-3-yl)propan-1-one
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![Compound (S) and (R)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide and use](/abs-image/US/2016/10/27/US20160311821A1/abs.jpg.150x150.jpg)
2.发明申请Compound (S) and (R)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide and use 有权化合物（S）和（R）-N-（2-氟吡啶-4-基）-3-甲基-2-（5-甲基-2,4-二氧代-1,2-二氢吡啶并[3,4-d] 嘧啶-3（4H） - 基）丁酰胺，并使用公开(公告)号：US20160311821A1
公开(公告)日：2016-10-27
申请号：US15132274
申请日：2016-04-19
Inventor： Jose-Miguel COTERON LOPEZ , Esther Pilar FERNANDEZ VELANDO , Jorge FERNANDEZ-MOLINA , Maria Luisa LEON-DIAZ , David Matthew WILSON
IPC: C07D471/04 , A61K45/06 , A61K31/519
CPC classification number: C07D471/04 , A61K31/519 , A61K45/06
Abstract: The present invention relates to a compound of Formula (I) having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (S)-N-(2-fluoropyridin-4-yl)-3-methyl-2-(5-methyl-2,4-dioxo-1,2-dihydropyrido[3,4-d]pyrimidin-3(4H)-yl)butanamide.
Abstract translation: （S）-N-（2-氟吡啶-4-基）-3-甲基-2-（5-甲基-2,4-二氧代-1,2-二氢吡啶并[3,4-d]嘧啶-3（4H ） - 基）丁酰胺。
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公开(公告)号：US20200095227A1
公开(公告)日：2020-03-26
申请号：US16515735
申请日：2019-07-18
Inventor： Dominique AMANS , Stephen John ATKINSON , Michael David BARKER , Matthew CAMPBELL , Hawa DIALLO , Clement DOUAULT , Neil Stuart GARTON , John LIDDLE , Jessica Fanny RENAUX , Robert John SHEPPARD , Ann Louise WALKER , Christopher Roland WELLAWAY , David Matthew WILSON
IPC: C07D401/14 , C07D498/06 , C07D405/14 , C07D413/14 , C07D403/14 , C07D498/04
Abstract: Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
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