公开(公告)号：US20170368034A1

公开(公告)日：2017-12-28

申请号：US15537637

申请日：2015-12-21

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Beatriz DIAZ HERNANDEZ ,  Pilar FERNANDEZ VELANDO ,  David Matthew WILSON

IPC: A61K31/4196 ,  A61K31/095 ,  A61K31/404 ,  A61K31/44 ,  C07D401/14 ,  G01N23/20

CPC classification number: A61K31/4196 ,  A61K31/095 ,  A61K31/404 ,  A61K31/44 ,  C07D401/14 ,  G01N23/20075 ,  Y02A50/411

Abstract: The present invention relates to a compound of Formula (I) or tautomers thereof having pharmacological activity, processes for its preparation, pharmaceutical compositions and their use in the treatment of certain parasitic certain parasitic protozoal infections such as malaria, in particular infection by Plasmodium falciparum. (R)-2-((3-(3,5-dichloropyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)-1-(1H-indol-3-yl)propan-1-one