公开(公告)号：US20190023715A1

公开(公告)日：2019-01-24

申请号：US16143788

申请日：2018-09-27

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Zehong WAN ,  Xiaomin ZHANG ,  Jian WANG ,  Matthew Robert SENDER ,  Eric Steven MANAS ,  Raphael Anthony RIVERO ,  Joseph E PERO ,  Christopher Ernst NEIPP ,  Vipulkumar Kantibhai PATEL

IPC分类号： C07D487/14 ,  C07D513/14 ,  C07D498/14 ,  C07D487/04 ,  C07D471/14 ,  C07D491/20 ,  C07D471/20

CPC分类号： C07D487/14 ,  C07D471/14 ,  C07D471/20 ,  C07D487/04 ,  C07D491/20 ,  C07D498/14 ,  C07D513/14 ,  H05K999/99

摘要： The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.