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公开(公告)号：US20170204108A1
公开(公告)日：2017-07-20
申请号：US15327685
申请日：2015-07-21
发明人： Zehong WAN , Xiaomin ZHANG , Jian WANG
IPC分类号： C07D487/14
CPC分类号： C07D487/14 , C07D471/14 , C07D471/20 , C07D487/04 , C07D491/20 , C07D498/14 , C07D513/14
摘要： The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
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公开(公告)号：US20150322075A1
公开(公告)日：2015-11-12
申请号：US14761634
申请日：2014-01-23
发明人： Zehong WAN , Xiaomin ZHANG
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel 3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
摘要翻译： 本发明涉及抑制Lp-PLA2活性的新型3,4-二氢-1H-嘧啶并[1,6-a]嘧啶-6（2H） - 酮化合物，其制备方法，含有它们的组合物及其 用于治疗与Lp-PLA2的活性相关的疾病，例如动脉粥样硬化，阿尔茨海默氏病。
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公开(公告)号：US20200002323A1
公开(公告)日：2020-01-02
申请号：US16480995
申请日：2018-01-23
发明人： Haifeng CUI , Feng REN , Yingxia SANG , Xiaomin ZHANG
IPC分类号： C07D413/14 , C07D401/14 , A61P25/16
摘要： Provided are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases associated with or characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).
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公开(公告)号：US20190023715A1
公开(公告)日：2019-01-24
申请号：US16143788
申请日：2018-09-27
发明人： Zehong WAN , Xiaomin ZHANG , Jian WANG , Matthew Robert SENDER , Eric Steven MANAS , Raphael Anthony RIVERO , Joseph E PERO , Christopher Ernst NEIPP , Vipulkumar Kantibhai PATEL
IPC分类号： C07D487/14 , C07D513/14 , C07D498/14 , C07D487/04 , C07D471/14 , C07D491/20 , C07D471/20
CPC分类号： C07D487/14 , C07D471/14 , C07D471/20 , C07D487/04 , C07D491/20 , C07D498/14 , C07D513/14 , H05K999/99
摘要： The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.
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公开(公告)号：US20150344485A1
公开(公告)日：2015-12-03
申请号：US14761631
申请日：2014-01-23
发明人： Zehong WAN , Xiaomin ZHANG
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel pyrimido[1,6-a]pyrimidin-6(2H)-one compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
摘要翻译： 本发明涉及抑制Lp-PLA2活性的新型嘧啶并[1,6-a]嘧啶-6（2H） - 酮化合物，其制备方法，含有它们的组合物及其用于治疗与 Lp-PLA2的活性，例如动脉粥样硬化，阿尔茨海默病。
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