专利检索 ap:("Glenmark Pharmaceuticals S.A.") AND inv:"Pierre Moretti" 第 1 页

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发明申请
EXPRESSION CONSTRUCTS AND METHODS FOR EXPRESSING POLYPEPTIDES IN EUKARYOTIC CELLS 审中-公开
标题翻译：用于表达欧洲核细胞中多肽的表达结构和方法

公开(公告)号：US20150056655A1

公开(公告)日：2015-02-26

申请号：US14453328

申请日：2014-08-06

申请人： Glenmark Pharmaceuticals S.A.

发明人： Christel AEBISCHER-GUMY , Martin Bertschinger , Pierre Moretti

IPC分类号： C07K16/46 , C12N15/85

CPC分类号： C07K16/468 , C07K16/32 , C07K2317/14 , C07K2317/52 , C07K2317/622 , C07K2317/64 , C12N15/85 , C12N2840/20 , C12N2840/445 , C12P21/02

摘要： The invention relates to an expression construct for the expression of polypeptides in host cells using alternative splicing. The expression construct can be used for the expression of polypeptides such as antibodies, antibody fragments and bispecific antibodies by expressing the gene products required for protein expression at the ratio leading to the highest titres or the best product quality profile.

摘要翻译： 本发明涉及使用选择性剪接在宿主细胞中表达多肽的表达构建体。通过以导致最高滴度或最佳产品质量分布的比例表达蛋白质表达所需的基因产物，表达构建体可用于表达多肽，例如抗体，抗体片段和双特异性抗体。