公开(公告)号：US09963481B2

公开(公告)日：2018-05-08

申请号：US14343426

申请日：2012-09-07

申请人： Glenn C. Micalizio ,  Thomas Kodadek ,  Mohosin Sarkar

发明人： Glenn C. Micalizio ,  Thomas Kodadek ,  Mohosin Sarkar

IPC分类号： C07K5/08 ,  A61K31/19 ,  A61K45/06 ,  C07D405/14 ,  C07D405/10 ,  C07B53/00 ,  C07C57/52 ,  C07C57/60 ,  C07C57/64 ,  A61K31/192 ,  A61K38/06 ,  C07C51/00 ,  C07K5/02 ,  C07K5/083 ,  G01N33/50 ,  C07C57/54

CPC分类号： C07K5/08 ,  A61K31/19 ,  A61K31/192 ,  A61K38/06 ,  A61K45/06 ,  C07B53/00 ,  C07B2200/07 ,  C07B2200/11 ,  C07C51/00 ,  C07C57/52 ,  C07C57/54 ,  C07C57/60 ,  C07C57/64 ,  C07D405/10 ,  C07D405/14 ,  C07K5/0205 ,  C07K5/0804 ,  G01N33/5008 ,  G01N2800/7028

摘要： Chiral oligomeric pentenoate amides are bio-oligomer mimetics possessing a high degree of conformation rigidity. Conformational rigidity is desirable in the design of molecules with high affinities for biological receptors and enzymes. Libraries of such oligomeric mimetics, such as of chiral oligomeric pentenoate amides can be used to probe biological systems. The present invention provides a method for preparation of chiral oligomeric pentanoate amides comprising conversion of a chiral oxazolidinone (4) to a chiral monomer of formula (1) which can be oligomerized to a chiral compound of formula (12) and so forth.