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公开(公告)号：US20220267337A1
公开(公告)日：2022-08-25
申请号：US17665942
申请日：2022-02-07
发明人： Lina Q. Setti , Shahul Nilar , Zhe Li , Ming Yu , Manuel Zancanella
IPC分类号： C07D487/04
摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US20190047981A1
公开(公告)日：2019-02-14
申请号：US16076307
申请日：2017-02-15
发明人： Ming Yu , Zhe Li , Lina Q. Setti
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , A61P35/00 , A61P37/00 , A61P29/00 , A61P7/00
摘要： The present disclosure provides certain compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies such as beta-thalassemia and sickle cell disease. Also provided are pharmaceutical compositions containing such compounds as well as processes and intermediates for preparing such compounds.
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公开(公告)号：US20230159538A1
公开(公告)日：2023-05-25
申请号：US17916530
申请日：2021-03-31
发明人： Ming Yu , Brian Edwin Cathers , Zhe Li , Brian Walter Metcalf , Lina Q. Setti , Chul Yu , Manuel Zancanella
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US20230151016A1
公开(公告)日：2023-05-18
申请号：US18155304
申请日：2023-01-17
发明人： Lina Q. Setti , Shahul Nilar , Zhe Li , Ming Yu , Manuel Zancanella
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US20230278984A1
公开(公告)日：2023-09-07
申请号：US18019379
申请日：2021-08-03
发明人： Lina Q. Setti , Brian Cathers , Zhe Li , Shahul Nilar , James Partridge , Chul Yu , Ming Yu , Manuel Zancanella
IPC分类号： C07D401/14 , C07D257/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D249/08
CPC分类号： C07D401/14 , C07D257/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D249/08
摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US10144746B2
公开(公告)日：2018-12-04
申请号：US15807331
申请日：2017-11-08
发明人： Zhe Li , Manuel Zancanella , Chul Yu , Lina Q. Setti , Hing Sham , Qing Xu , Calvin W. Yee , Ming Yu
IPC分类号： C07D519/00 , C07D405/12 , C07D307/81 , C07D491/18 , C07D493/08 , C07D471/08 , C07D213/73 , C07B59/00 , C07D401/12 , C07D487/08
摘要： Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
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![Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators](/abs-image/US/2023/01/31/US11566030B2/abs.jpg.150x150.jpg)
公开(公告)号：US11566030B2
公开(公告)日：2023-01-31
申请号：US17665942
申请日：2022-02-07
发明人： Lina Q. Setti , Shahul Nilar , Zhe Li , Ming Yu , Manuel Zancanella
IPC分类号： A61K31/4162 , C07D487/04
摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I: and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US11254651B2
公开(公告)日：2022-02-22
申请号：US16076307
申请日：2017-02-15
发明人： Ming Yu , Zhe Li , Lina Q. Setti
IPC分类号： C07D401/12 , C07D405/14 , A61P37/00 , A61P7/00 , A61P29/00 , A61P35/00 , C07D401/14
摘要： The present disclosure provides certain compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinpathies such as beta-thalassemia and sickle cell disease. Also provided are pharmaceutical compositions containing such compounds as well as processes and intermediates for preparing such compounds.
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公开(公告)号：US20180194780A1
公开(公告)日：2018-07-12
申请号：US15807331
申请日：2017-11-08
发明人： Zhe Li , Manuel Zancanella , Chul Yu , Lina Q. Setti , Hing Sham , Qing Xu , Calvin W. Yee , Ming Yu
IPC分类号： C07D519/00 , C07D493/08 , C07D491/18 , C07D487/08 , C07D471/08 , C07B59/00 , C07D401/12 , C07D307/81 , C07D213/73 , C07D405/12
CPC分类号： C07D519/00 , C07B59/002 , C07B2200/05 , C07D213/73 , C07D307/81 , C07D401/12 , C07D405/12 , C07D471/08 , C07D487/08 , C07D491/18 , C07D493/08
摘要： Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
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