公开(公告)号：US11707474B2

公开(公告)日：2023-07-25

申请号：US16978508

申请日：2019-03-04

申请人： GlycoMimetics, Inc.

发明人： Helen M. Thackray ,  Henry H. Flanner ,  Curt D. Wolfgang

IPC分类号： A61K31/702 ,  A61P35/00 ,  A61K9/00

CPC分类号： A61K31/702 ,  A61K9/0019 ,  A61P35/00

摘要： Methods for treating or inhibiting cancer and/or one or more related conditions by administering to a subject in need thereof an effective amount of a compound of Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of any of the foregoing. For example, methods for treating AML, MDS, neutropenia, and/or mucositis comprising administering a pharmaceutical composition comprising a compound of Formula (I) are described.

公开(公告)号：US20220289784A1

公开(公告)日：2022-09-15

申请号：US17636512

申请日：2020-08-18

申请人： GLYCOMIMETICS, INC.

发明人： Henry H. Flanner ,  John M. Peterson ,  Arun K. Sarkar ,  John L. Magnani ,  Gerd Osswald ,  Daniel Schwizer ,  Marc Lanz ,  Andreas Helmut Bernd Kyas

IPC分类号： C07H15/207 ,  C07H1/00

摘要： A process is provided for the synthesis of an intermediate of Formula 15 which is useful in the synthesis of E-selectin inhibitors. Also provided are useful intermediates obtained from the process.