公开(公告)号：US11845771B2

公开(公告)日：2023-12-19

申请号：US17418579

申请日：2019-12-26

申请人： GLYCOMIMETICS, INC.

发明人： John L. Magnani ,  John M. Peterson ,  Arun K. Sarkar ,  Yusufbhai U. Vohra ,  Indranath Ghosh ,  Jason Nogueira

IPC分类号： C07H19/056

CPC分类号： C07H19/056

摘要： Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.

公开(公告)号：US11712446B2

公开(公告)日：2023-08-01

申请号：US16767698

申请日：2018-11-29

申请人： GLYCOMIMETICS, INC.

发明人： John L. Magnani ,  William Fogler

IPC分类号： A61K31/7034 ,  A61P35/00 ,  A61K35/17 ,  A61K38/19

CPC分类号： A61K31/7034 ,  A61K35/17 ,  A61K38/193 ,  A61P35/00

摘要： Methods are disclosed for the mobilization of marrow infiltrating cells (MILs) using E-selectin antagonists for the treatment of disorders such as cancer. Methods for treating or preventing cancers using MILs mobilized by E-selectin antagonists are further disclosed.

公开(公告)号：US11707474B2

公开(公告)日：2023-07-25

申请号：US16978508

申请日：2019-03-04

申请人： GlycoMimetics, Inc.

发明人： Helen M. Thackray ,  Henry H. Flanner ,  Curt D. Wolfgang

IPC分类号： A61K31/702 ,  A61P35/00 ,  A61K9/00

CPC分类号： A61K31/702 ,  A61K9/0019 ,  A61P35/00

摘要： Methods for treating or inhibiting cancer and/or one or more related conditions by administering to a subject in need thereof an effective amount of a compound of Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of any of the foregoing. For example, methods for treating AML, MDS, neutropenia, and/or mucositis comprising administering a pharmaceutical composition comprising a compound of Formula (I) are described.

公开(公告)号：US20190233458A1

公开(公告)日：2019-08-01

申请号：US16339646

申请日：2017-10-06

申请人： GLYCOMIMETICS, INC.

发明人： John L. MAGNANI ,  John M. PETERSON ,  Myung-Gi BAEK

IPC分类号： C07H7/06 ,  A61P1/04 ,  A61P35/04 ,  C07H7/04

CPC分类号： C07H7/06 ,  A61K47/60 ,  A61P1/04 ,  A61P35/04 ,  C07H7/04 ,  C07H15/207 ,  C07H15/26

摘要： Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, highly potent multimeric E-selectin antagonist are dessorbed and pharmaceutical compositions comprising at least one of the same.

公开(公告)号：US20170305951A1

公开(公告)日：2017-10-26

申请号：US15531951

申请日：2015-12-01

申请人： GlycoMimetics, Inc.

发明人： John L MAGNANI ,  Arun K. SARKAR ,  John M. PETERSON

IPC分类号： C07H15/26

摘要： Compounds, compositions, and methods for treatment and/or prevention of cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood are disclosed. For example, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described and pharmaceutical compositions comprising at least one of the same.

公开(公告)号：US09796745B2

公开(公告)日：2017-10-24

申请号：US14752056

申请日：2015-06-26

申请人： GlycoMimetics, Inc.

发明人： John L. Magnani ,  Arun K. Sarkar ,  Myung-Gi Baek ,  Frank E. Anderson, III ,  Yanhong Li

IPC分类号： A61K31/7034 ,  C07H15/207 ,  A61K45/06 ,  C07H15/26

CPC分类号： C07H15/207 ,  A61K31/7034 ,  A61K45/06 ,  C07H15/26 ,  C09C1/62

摘要： Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selection antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

公开(公告)号：US20160289257A1

公开(公告)日：2016-10-06

申请号：US15182819

申请日：2016-06-15

申请人： GlycoMimetics, Inc.

发明人： John L. Magnani ,  Arun K. Sarkar

IPC分类号： C07H15/207 ,  C07H15/26

CPC分类号： C07H15/207 ,  A61K47/55 ,  C07H15/26

摘要： Compounds, compositions and methods are provided for use to inhibit infection by human immunodeficiency virus (HIV). More specifically, the present invention relates to glycomimetic compounds that inhibit HIV infection, and uses thereof.

摘要翻译： 提供化合物，组合物和方法用于抑制人免疫缺陷病毒（HIV）的感染。 更具体地，本发明涉及抑制HIV感染的糖模拟化合物及其用途。

公开(公告)号：US20040254145A1

公开(公告)日：2004-12-16

申请号：US10440476

申请日：2003-05-16

申请人： GlycoMimetics, Inc.

发明人： John L. Magnani ,  John T. Patton JR. ,  Leonard M. Williams

IPC分类号： A61K031/704

CPC分类号： C07H15/252

摘要： Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.

摘要翻译： 提供化合物和方法用于调节由选择素结合介导的体外和体内过程。 更具体地，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂包含称为BASAs的一类化合物（苄基氨基磺酸，其包括其部分或类似物） 与碳水化合物或糖模拟物连接。

公开(公告)号：US20240270724A1

公开(公告)日：2024-08-15

申请号：US18560441

申请日：2022-05-13

申请人： GLYCOMIMETICS, INC.

发明人： John L. MAGNANI ,  John M. PETERSON ,  Yusuf U. VOHRA ,  lndranath GHOSH ,  Jason NOGUEIRA ,  Arun K. SARKAR ,  Debatosh MAJUMDAR

IPC分类号： C07D405/04 ,  A61K31/4192

CPC分类号： C07D405/04 ,  A61K31/4192

摘要： Compounds of formula (I), compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to a ligand are disclosed. For example, inhibitors of galectin-3 are described and pharmaceutical compositions comprising at least one such inhibitor are described.

公开(公告)号：US20240269157A1

公开(公告)日：2024-08-15

申请号：US18291884

申请日：2022-08-02

申请人： GLYCOMIMETICS, INC.

发明人： William E. FOGLER ,  John L. MAGNANI ,  Theodore SMITH

IPC分类号： A61K31/7052 ,  A61K31/635 ,  A61K31/706 ,  A61P35/02

CPC分类号： A61K31/7052 ,  A61K31/635 ,  A61K31/706 ,  A61P35/02

摘要： Methods for treating a cancer (such as, e.g., acute myeloid leukemia) comprising administering to a subject (such as, e.g., a subject who has acquired resistance to a therapy comprising at least one antineoplastic agent and/or at least one hypomethylating agent) at least one E-selectin antagonist, wherein the subject is further administered at least one antineoplastic agent (such as, e.g., venetoclax) and/or at least one hypomethylating agent are disclosed.