公开(公告)号：US08580795B2

公开(公告)日：2013-11-12

申请号：US13143480

申请日：2010-01-21

申请人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

发明人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

IPC分类号： A61K31/496 ,  C07D405/14

CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.

摘要翻译： 式（I）化合物，其衍生物，类似物，互变异构体，区域异构体，立体异构体，多晶型物，溶剂合物，中间体，药学上可接受的盐，药物组合物，N-氧化物，代谢物和前药。 这些化合物是磷酸二酯酶4型（PDE4）抑制剂。 它们可用于治疗各种过敏或炎性疾病，包括哮喘，COPD，慢性支气管炎，特应性皮炎，过敏性鼻炎，过敏性结膜炎，春季结膜炎，牛皮癣，类风湿性关节炎，溃疡性结肠炎，克罗恩病，葡萄膜炎，NASH和狼疮 。

公开(公告)号：US20110269753A1

公开(公告)日：2011-11-03

申请号：US13143480

申请日：2010-01-21

申请人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

发明人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

IPC分类号： A61K31/4439 ,  C07D407/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D498/04 ,  C07D498/14 ,  A61K31/427 ,  A61K31/506 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61P29/00 ,  A61P37/00 ,  A61P11/06 ,  A61P11/00 ,  A61P11/08 ,  A61P17/00 ,  A61P27/14 ,  A61P17/06 ,  A61P1/04 ,  A61P1/00 ,  A61P27/02 ,  A61P19/04 ,  C07D417/14

CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.

摘要翻译： 式（I）化合物，其衍生物，类似物，互变异构体，区域异构体，立体异构体，多晶型物，溶剂合物，中间体，药学上可接受的盐，药物组合物，N-氧化物，代谢物和前药。 这些化合物是磷酸二酯酶4型（PDE4）抑制剂。 它们可用于治疗各种过敏或炎性疾病，包括哮喘，COPD，慢性支气管炎，特应性皮炎，过敏性鼻炎，过敏性结膜炎，春季结膜炎，牛皮癣，类风湿性关节炎，溃疡性结肠炎，克罗恩病，葡萄膜炎，NASH和狼疮 。