公开(公告)号：US08580795B2

公开(公告)日：2013-11-12

申请号：US13143480

申请日：2010-01-21

申请人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

发明人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

IPC分类号： A61K31/496 ,  C07D405/14

CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.

摘要翻译： 式（I）化合物，其衍生物，类似物，互变异构体，区域异构体，立体异构体，多晶型物，溶剂合物，中间体，药学上可接受的盐，药物组合物，N-氧化物，代谢物和前药。 这些化合物是磷酸二酯酶4型（PDE4）抑制剂。 它们可用于治疗各种过敏或炎性疾病，包括哮喘，COPD，慢性支气管炎，特应性皮炎，过敏性鼻炎，过敏性结膜炎，春季结膜炎，牛皮癣，类风湿性关节炎，溃疡性结肠炎，克罗恩病，葡萄膜炎，NASH和狼疮 。

公开(公告)号：US20110269753A1

公开(公告)日：2011-11-03

申请号：US13143480

申请日：2010-01-21

申请人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

发明人： Gopalan Balasubramanian ,  Sukunath Narayanan ,  Ganapavarapu Veera Raghava Sharma ,  Lavanya Andiappan ,  Shridhar Narayanan ,  Sanjeev Saxena ,  Sridharan Rajagopal ,  Santosh Lolaknath Vishwakarma ,  Saravanan Thirunavukkarasu

IPC分类号： A61K31/4439 ,  C07D407/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D498/04 ,  C07D498/14 ,  A61K31/427 ,  A61K31/506 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61P29/00 ,  A61P37/00 ,  A61P11/06 ,  A61P11/00 ,  A61P11/08 ,  A61P17/00 ,  A61P27/14 ,  A61P17/06 ,  A61P1/04 ,  A61P1/00 ,  A61P27/02 ,  A61P19/04 ,  C07D417/14

CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.

摘要翻译： 式（I）化合物，其衍生物，类似物，互变异构体，区域异构体，立体异构体，多晶型物，溶剂合物，中间体，药学上可接受的盐，药物组合物，N-氧化物，代谢物和前药。 这些化合物是磷酸二酯酶4型（PDE4）抑制剂。 它们可用于治疗各种过敏或炎性疾病，包括哮喘，COPD，慢性支气管炎，特应性皮炎，过敏性鼻炎，过敏性结膜炎，春季结膜炎，牛皮癣，类风湿性关节炎，溃疡性结肠炎，克罗恩病，葡萄膜炎，NASH和狼疮 。

公开(公告)号：US08420653B2

公开(公告)日：2013-04-16

申请号：US12863796

申请日：2009-01-30

申请人： Visweswara Akella Satya Surya Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Thirunavukkarasu Sappanimuthu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narasimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran ,  Gopalan Balasubramanian ,  Narayanan Surendran ,  Shridhar Narayanan ,  Lolaknath Santosh Vishwakarma ,  Sanjeev Saxena ,  Nishikanth Reddy Gaddam

发明人： Visweswara Akella Satya Surya Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Thirunavukkarasu Sappanimuthu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narasimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Om Reddy Gaddam ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran ,  Gopalan Balasubramanian ,  Narayanan Surendran ,  Shridhar Narayanan ,  Lolaknath Santosh Vishwakarma ,  Sanjeev Saxena

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04

CPC分类号： C07D239/42 ,  A61K31/5377 ,  C07D265/28 ,  C07D401/04

摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 败血症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US20100329998A1

公开(公告)日：2010-12-30

申请号：US12863796

申请日：2009-01-30

申请人： Visweswara Akella Satya Surya Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Thirunavukkarasu Sappanimuthu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narasimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Om Gaddam ,  Nishikanth Reddy Gaddam ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran ,  Gopalan Balasubramanian ,  Narayanan Surendran ,  Shridhar Narayanan ,  Lolaknath Santosh Vishwakarma ,  Sanjeev Saxena

发明人： Visweswara Akella Satya Surya Srinivas ,  Ravikumar Tadiparthi ,  Ganapavarapu Veera Raghava Sharma ,  Thirunavukkarasu Sappanimuthu ,  Durairaj Peter Bhakiaraj ,  Virendra Kachhadia ,  Kilambi Narasimhan ,  Sathya Narayana Thara ,  Sriram Rajagopal ,  Om Gaddam ,  Nishikanth Reddy Gaddam ,  Sukunath Narayanan ,  Venkatesan Parameswaran ,  Venkatesan Janarthanam ,  Maruthikumar Narayanam ,  Sathyanarayana Gadde ,  Uma Ramachandran ,  Gopalan Balasubramanian ,  Narayanan Surendran ,  Shridhar Narayanan ,  Lolaknath Santosh Vishwakarma ,  Sanjeev Saxena

IPC分类号： A61K9/12 ,  A61K31/505 ,  C07D239/02 ,  C07D401/14 ,  A61K31/506 ,  A61K31/497 ,  C07D417/04 ,  C07D403/04 ,  C07D413/12 ,  A61K31/5377 ,  A61K31/54 ,  A61P37/00 ,  A61P29/00 ,  A61P19/02 ,  A61P19/10 ,  A61P35/02 ,  A61P35/04 ,  A61P9/00 ,  A61P1/00 ,  A61P11/00

CPC分类号： C07D239/42 ,  A61K31/5377 ,  C07D265/28 ,  C07D401/04

摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.

摘要翻译： 描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。 这些化合物可用于治疗免疫疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症 多发性骨髓瘤 葡萄膜炎 急性和慢性粒细胞白血病; 动脉粥样硬化 癌症; 恶病质 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎 类风湿性脊柱炎; 痛风性关节炎 炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎 过敏反应 接触性皮炎; 肌肉退化; 哮喘; COPD; 骨吸收疾病; 多发性硬化症 败血症 败血性休克 中毒性休克综合征和发烧。 更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

公开(公告)号：US20090263003A1

公开(公告)日：2009-10-22

申请号：US12386840

申请日：2009-04-24

申请人： George Madathilparambil George ,  Sanjeev Saxena

发明人： George Madathilparambil George ,  Sanjeev Saxena

IPC分类号： G06K9/00

CPC分类号： G06K9/6261 ,  G06T7/0012 ,  G06T2207/20081 ,  G06T2207/30096

摘要： A method for dividing value space of parameters into ranges using samples wherein these ranges are used for detection of cancer in a region or segment in a digital image. A method for assisting the investigation in detection of cancer in a region in a first digital image of a human body or a human body part using ranges of parameters computed using samples. A method for performing medical diagnostics for detection of cancer over a computer network.

摘要翻译： 使用样本将参数的值空间划分为范围的方法，其中这些范围用于在数字图像中的区域或片段中检测癌症。 一种使用样本计算的参数范围来辅助在人体或人体部位的第一数字图像的区域中检测癌症的方法。 一种用于在计算机网络上进行用于检测癌症的医学诊断的方法。

公开(公告)号：US5469573A

公开(公告)日：1995-11-21

申请号：US023091

申请日：1993-02-26

申请人： James K. McGill, III ,  Dorotea Abele ,  Lonnie L. Colman ,  Manuel Gonsalves ,  Sanjeev Saxena

发明人： James K. McGill, III ,  Dorotea Abele ,  Lonnie L. Colman ,  Manuel Gonsalves ,  Sanjeev Saxena

IPC分类号： G06F11/14

CPC分类号： G06F11/1456 ,  G06F11/1458 ,  G06F11/1469

摘要： This invention features a data backup procedure and apparatus for backing up and restoring, or otherwise loading a fully configured operating system to the high capacity storage device (e.g., hard disk) of a computer workstation, such as a personal computer. The method includes providing a first media having the desired operating system files to be loaded onto the storage device, providing a second media having configuration-specific data files, initializing the data processing system from the second media to provide a temporary operating system using the configuration-specific data files, loading the desired operating system files from the first media to the storage device using the temporary operating system, and reinitializing the data processing system with the desired operating system from the storage device. Embodiments of the method include providing the first media by copying the desired operating system files, or all the files, stored on the storage device to the first media. The copying can be achieved by running a data backup routine. Other embodiments include providing the configuration-specific data files to the second media by copying the configuration-specific data files from the storage device to the second media.

摘要翻译： 本发明的特征在于数据备份过程和装置，用于将完全配置的操作系统备份和恢复或以其他方式加载到诸如个人计算机的计算机工作站的高容量存储设备（例如，硬盘）。 该方法包括提供具有要加载到存储设备上的所需操作系统文件的第一介质，提供具有配置特定数据文件的第二介质，从第二介质初始化数据处理系统以提供使用该配置的临时操作系统 特定的数据文件，使用临时操作系统将期望的操作系统文件从第一媒体加载到存储设备，以及使用所需操作系统从存储设备重新初始化数据处理系统。 该方法的实施例包括通过将存储在存储设备上的所需操作系统文件或所有文件复制到第一媒体来提供第一媒体。 可以通过运行数据备份例程来实现复制。 其他实施例包括通过将配置专用数据文件从存储设备复制到第二媒体来向第二媒体提供配置专用数据文件。