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公开(公告)号：US20170312271A1
公开(公告)日：2017-11-02
申请号：US15649880
申请日：2017-07-14
申请人： Grünenthal GmbH
IPC分类号： A61K31/485 , A61J3/10 , A61K9/20 , B29C43/02 , B29B9/12 , B29B9/02 , B29B7/00 , A61K31/554 , A61K31/55 , A61J3/00 , A61K31/4418 , A61K31/277 , A61K31/135 , A61K9/48 , A61K9/28 , A61K31/4422 , B29C35/02 , B29C45/00 , B29K105/00 , B29L31/00
摘要： The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
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公开(公告)号：US20180369235A1
公开(公告)日：2018-12-27
申请号：US16016924
申请日：2018-06-25
申请人： GRÜNENTHAL GMBH
IPC分类号： A61K31/485 , A61K31/55 , A61J3/06 , A61J3/10 , A61K9/20 , B29C47/06 , B29C47/00 , B29C43/02 , B29B9/12 , B29B9/02 , B29B7/00 , A61K31/554 , A61J3/00 , A61K31/4422 , A61K31/4418 , A61K31/277 , A61K31/135 , A61K9/48 , A61K9/28 , B29C45/00 , B29C35/02 , A61K9/00 , B29L31/00 , B29K105/00
摘要： The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary, substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
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