公开(公告)号：US08133336B2

公开(公告)日：2012-03-13

申请号：US12278252

申请日：2007-02-02

申请人： Graeme Kettlewell ,  David Mandley ,  David Fortune ,  Ian Thompson ,  Diane Morris

发明人： Graeme Kettlewell ,  David Mandley ,  David Fortune ,  Ian Thompson ,  Diane Morris

IPC分类号： B29C65/00

CPC分类号： A61L31/10 ,  A61L24/0094 ,  A61L26/0095 ,  A61L27/34 ,  A61L31/129 ,  Y10T156/10 ,  Y10T428/2495 ,  Y10T428/31511 ,  Y10T428/31786 ,  Y10T428/31938

摘要： A multi-lamellar tissue-adhesive sheet comprises a structural layer or laminate conjoined to a tissue-contacting layer. The structural layer or laminate comprises one or more synthetic polymers having film-forming properties, and the tissue-contacting layer of material contains tissue-reactive groups. The synthetic polymers having film-forming properties are preferably biodegradable polyesters, and the tissue-reactive groups are most preferably NHS-ester groups.

摘要翻译： 多层薄纸粘合片包括与组织接触层结合的结构层或层压体。 结构层或层压体包含一种或多种具有成膜性质的合成聚合物，并且材料的组织接触层含有组织反应性基团。 具有成膜性的合成聚合物优选是可生物降解的聚酯，组织反应性基团最优选为NHS-酯基。

公开(公告)号：US20070286891A1

公开(公告)日：2007-12-13

申请号：US11572976

申请日：2005-07-29

申请人： Graeme Kettlewell ,  David Mandley ,  David Fortune ,  Ian Thompson ,  Diane Morris

发明人： Graeme Kettlewell ,  David Mandley ,  David Fortune ,  Ian Thompson ,  Diane Morris

IPC分类号： A61L15/58 ,  C08F26/10

CPC分类号： A61L15/58

摘要： This invention related to a tissue-adhesive sheet comprising a homogeneous, preformed and cross-linked matrix formed from one or more polymers, and having at least one surface that, in use, is exposed, at least one of said one or more polymers being a synthetic polymer and having appendant functional groups of a first form, cross-linking of said matrix being via a proportion of said functional groups of the first form, and the remainder of said functional groups of the first form being free. The sheet is particularly useful as a tissue adhesive and sealant, and is intended for topical application to internal and external surfaces of the body for therapeutic reasons. The invention further relates to sheets comprising a scaffold material, three-dimensional articles formed from similar material to that of the sheet and to implantable medical devices coated with such material.

摘要翻译： 本发明涉及包含由一种或多种聚合物形成的均匀的，预先形成的和交联的基质并且在使用中暴露的至少一个表面的组织粘合片，所述一种或多种聚合物中的至少一种是 合成聚合物并具有第一形式的附加官能团，所述基质的交联经由所述第一形式的所述官能团的一部分，所述第一形式的所述官能团的剩余部分是游离的。 该片材作为组织粘合剂和密封剂是特别有用的，出于治疗原因而用于局部施用于身体的内部和外部表面。 本发明还涉及包括支架材料的片材，由与片材类似的材料形成的三维制品以及涂覆有这种材料的可植入医疗装置。

公开(公告)号：US20060105026A1

公开(公告)日：2006-05-18

申请号：US10552095

申请日：2004-04-02

申请人： David Fortune ,  Graeme Kettlewell ,  David Mandley ,  Ian Thompson ,  Diane Cook

发明人： David Fortune ,  Graeme Kettlewell ,  David Mandley ,  Ian Thompson ,  Diane Cook

IPC分类号： A61K9/70 ,  A61L15/00

CPC分类号： A61L31/047 ,  A61L15/225 ,  A61L15/32 ,  A61L24/043 ,  A61L24/108 ,  A61L31/041

摘要： A tissue-adhesive formulation consists of a naturally occurring or synthetic polymerisable and/or cross-linkable material in particulate form, the polymerisable and/or cross-linkable material being in admixture with particulate material comprising tissue-reactive functional groups. The formulation may be used in the preparation of a tissue-adhesive sheet, by applying the formulation to at least one side of a core of a naturally occurring or synthetic polymeric material.

摘要翻译： 组织粘合剂制剂由颗粒形式的天然存在或合成的可聚合和/或可交联材料组成，可聚合和/或可交联材料与包含组织反应性官能团的颗粒材料混合。 通过将制剂应用于天然存在或合成的聚合物材料的核心的至少一侧，该制剂可用于制备薄纸粘合片材。